sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow

ABSTRACT Objective To analyze the value of the soluble fms‐like tyrosine kinase‐1/placental growth factor (sFlt‐1/PlGF) ratio in predicting the time to delivery in early‐onset fetal growth restriction (FGR) with preserved antegrade umbilical artery (UA) flow at diagnosis. Methods This was a prospect...

Descripción completa

Detalles Bibliográficos
Autores: Quezada, M. S., Rodríguez Calvo, J., Villalain González, Cecilia, Gómez Arriaga, P. I., Galindo Izquierdo, Alberto, Herraiz García, Ignacio
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/114845
Acceso en línea:https://hdl.handle.net/20.500.14352/114845
Access Level:acceso abierto
Palabra clave:Ginecología y obstetricia
3201.08 Ginecología
id ES_a2dfb23c0b71e8d9b4ff394fa9ef3d23
oai_identifier_str oai:docta.ucm.es:20.500.14352/114845
network_acronym_str ES
network_name_str España
repository_id_str
spelling sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flowQuezada, M. S.Rodríguez Calvo, J.Villalain González, CeciliaGómez Arriaga, P. I.Galindo Izquierdo, AlbertoHerraiz García, IgnacioGinecología y obstetricia3201.08 GinecologíaABSTRACT Objective To analyze the value of the soluble fms‐like tyrosine kinase‐1/placental growth factor (sFlt‐1/PlGF) ratio in predicting the time to delivery in early‐onset fetal growth restriction (FGR) with preserved antegrade umbilical artery (UA) flow at diagnosis. Methods This was a prospective observational single‐center cohort study of pregnancies with early‐onset (< 32 + 0 weeks) FGR and antegrade UA flow, in which maternal serum sFlt‐1/PlGF ratio was determined at diagnosis. FGR was defined as estimated fetal weight < 3rd centile or < 10th centile with UA pulsatility index > 95th centile, fetal middle cerebral artery pulsatility index < 5th centile or cerebroplacental ratio < 5th centile. The previously described sFlt‐1/PlGF ratio cut‐off value of 85 for facilitating the diagnosis of pre‐eclampsia was assessed in the prediction of the need to deliver in < 1 week and ≥ 4 weeks. Results In total, 120 cases were included. There were 116 (96.7%) liveborn neonates and 108 (90.0%) perinatal survivors. Median (interquartile range (IQR)) gestational age at diagnosis of early‐onset FGR was 27.1 (25.7–29.4) weeks. Median (IQR) sFlt‐1/PlGF ratio at diagnosis was 196 (84–474). Ninety (75.0%) cases had a sFlt‐1/PlGF ratio ≥ 85. Among pregnancies with a liveborn neonate, median (IQR) interval to delivery in the groups with sFlt‐1/PlGF ratio < 85 and ≥ 85 was 41 (22–54) days and 11 (4–20) days, respectively (P < 0.01). The probability of having to deliver within 1 week after diagnosis was 0% and 35.6% in those with sFlt‐1/PlGF ratio < 85 and ≥ 85, respectively (P = 0.03), and the probability of delaying delivery for ≥ 4 weeks was 72.4% and 19.5%, respectively (P < 0.01). Conclusion sFlt‐1/PlGF ratio < 85 at diagnosis of early‐onset FGR with antegrade UA flow identifies a group of pregnancies in which the need to deliver within 1 week is very low and the interval to delivery is expected to be prolonged for ≥ 4 weeks in > 70% of cases. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.WileyUniversidad Complutense de Madrid20202020-10-0120202020-10-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/20.500.14352/114845reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1148452026-06-02T12:44:21Z
dc.title.none.fl_str_mv sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow
title sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow
spellingShingle sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow
Quezada, M. S.
Ginecología y obstetricia
3201.08 Ginecología
title_short sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow
title_full sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow
title_fullStr sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow
title_full_unstemmed sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow
title_sort sFlt-1/PlGF ratio and timing of delivery in early-onset fetal growth restriction with antegrade umbilical artery flow
dc.creator.none.fl_str_mv Quezada, M. S.
Rodríguez Calvo, J.
Villalain González, Cecilia
Gómez Arriaga, P. I.
Galindo Izquierdo, Alberto
Herraiz García, Ignacio
author Quezada, M. S.
author_facet Quezada, M. S.
Rodríguez Calvo, J.
Villalain González, Cecilia
Gómez Arriaga, P. I.
Galindo Izquierdo, Alberto
Herraiz García, Ignacio
author_role author
author2 Rodríguez Calvo, J.
Villalain González, Cecilia
Gómez Arriaga, P. I.
Galindo Izquierdo, Alberto
Herraiz García, Ignacio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Ginecología y obstetricia
3201.08 Ginecología
topic Ginecología y obstetricia
3201.08 Ginecología
description ABSTRACT Objective To analyze the value of the soluble fms‐like tyrosine kinase‐1/placental growth factor (sFlt‐1/PlGF) ratio in predicting the time to delivery in early‐onset fetal growth restriction (FGR) with preserved antegrade umbilical artery (UA) flow at diagnosis. Methods This was a prospective observational single‐center cohort study of pregnancies with early‐onset (< 32 + 0 weeks) FGR and antegrade UA flow, in which maternal serum sFlt‐1/PlGF ratio was determined at diagnosis. FGR was defined as estimated fetal weight < 3rd centile or < 10th centile with UA pulsatility index > 95th centile, fetal middle cerebral artery pulsatility index < 5th centile or cerebroplacental ratio < 5th centile. The previously described sFlt‐1/PlGF ratio cut‐off value of 85 for facilitating the diagnosis of pre‐eclampsia was assessed in the prediction of the need to deliver in < 1 week and ≥ 4 weeks. Results In total, 120 cases were included. There were 116 (96.7%) liveborn neonates and 108 (90.0%) perinatal survivors. Median (interquartile range (IQR)) gestational age at diagnosis of early‐onset FGR was 27.1 (25.7–29.4) weeks. Median (IQR) sFlt‐1/PlGF ratio at diagnosis was 196 (84–474). Ninety (75.0%) cases had a sFlt‐1/PlGF ratio ≥ 85. Among pregnancies with a liveborn neonate, median (IQR) interval to delivery in the groups with sFlt‐1/PlGF ratio < 85 and ≥ 85 was 41 (22–54) days and 11 (4–20) days, respectively (P < 0.01). The probability of having to deliver within 1 week after diagnosis was 0% and 35.6% in those with sFlt‐1/PlGF ratio < 85 and ≥ 85, respectively (P = 0.03), and the probability of delaying delivery for ≥ 4 weeks was 72.4% and 19.5%, respectively (P < 0.01). Conclusion sFlt‐1/PlGF ratio < 85 at diagnosis of early‐onset FGR with antegrade UA flow identifies a group of pregnancies in which the need to deliver within 1 week is very low and the interval to delivery is expected to be prolonged for ≥ 4 weeks in > 70% of cases. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-10-01
2020
2020-10-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/114845
url https://hdl.handle.net/20.500.14352/114845
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415333371052032
score 15,81155

Similares en LA Referencia