Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models

Introduction: Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of t...

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Authors: Illa Armengol, Míriam, Eixarch Roca, Elisenda, Muñoz-Moreno, Emma, Batallé Bolaño, Dafnis, Leal Campanario, Rocio, Gruart i Massó, Agnès, Delgado Garcia, José M., Figueras Retuerta, Francesc, Gratacós Solsona, Eduard
Format: article
Status:Versión aceptada para publicación
Publication Date:2017
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/125371
Online Access:https://hdl.handle.net/2445/125371
Access Level:Open access
Keyword:Malnutrició
Retard del creixement intrauterí
Neonatologia
Models animals en la investigació
Malnutrition
Fetal growth retardation
Neonatology
Animal models in research
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spelling Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit modelsIlla Armengol, MíriamEixarch Roca, ElisendaMuñoz-Moreno, EmmaBatallé Bolaño, DafnisLeal Campanario, RocioGruart i Massó, AgnèsDelgado Garcia, José M.Figueras Retuerta, FrancescGratacós Solsona, EduardMalnutricióRetard del creixement intrauteríNeonatologiaModels animals en la investigacióMalnutritionFetal growth retardationNeonatologyAnimal models in researchIntroduction: Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of the neurodevelopmental effects of both situations in pregnant rabbits was performed. Materials and Methods: The placental underperfusion model was induced after uteroplacental vessel ligation at 25 days of pregnancy. The undernutrition model was induced after a reduction of 70% of the basal maternal intake at 22 days of pregnancy. Neurobehavioral tests were applied in the derived offspring at the neonatal period and over the long term. Structural brain differences were evaluated by brain networks obtained from diffusion magnetic resonance imaging. Results: Birth weight was significantly lower in both cases. However, stillbirth was only increased in the placental underperfusion model. Cases from both models presented poorer neurobehavioral performance and network infrastructure, being more pro-nounced in the placental underperfusion model. Discussion: Prenatal insults during the last third of gestation resulted in functional and structural disturbances. The degree of neurodevelopmental impairment and its association with structural brain reorganization seemed to be related to the type of the prenatal insult, showing stronger effects in the placental underperfusion model. (C) 2017 S. Karger AG, BaselKarger2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/125371Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1159/000454859Fetal Diagnosis and Therapy, 2017, vol. 42, num. 3, p. 189-197https://doi.org/10.1159/000454859(c) Karger, 2017info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1253712026-05-27T06:46:51Z
dc.title.none.fl_str_mv Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
title Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
spellingShingle Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
Illa Armengol, Míriam
Malnutrició
Retard del creixement intrauterí
Neonatologia
Models animals en la investigació
Malnutrition
Fetal growth retardation
Neonatology
Animal models in research
title_short Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
title_full Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
title_fullStr Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
title_full_unstemmed Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
title_sort Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
dc.creator.none.fl_str_mv Illa Armengol, Míriam
Eixarch Roca, Elisenda
Muñoz-Moreno, Emma
Batallé Bolaño, Dafnis
Leal Campanario, Rocio
Gruart i Massó, Agnès
Delgado Garcia, José M.
Figueras Retuerta, Francesc
Gratacós Solsona, Eduard
author Illa Armengol, Míriam
author_facet Illa Armengol, Míriam
Eixarch Roca, Elisenda
Muñoz-Moreno, Emma
Batallé Bolaño, Dafnis
Leal Campanario, Rocio
Gruart i Massó, Agnès
Delgado Garcia, José M.
Figueras Retuerta, Francesc
Gratacós Solsona, Eduard
author_role author
author2 Eixarch Roca, Elisenda
Muñoz-Moreno, Emma
Batallé Bolaño, Dafnis
Leal Campanario, Rocio
Gruart i Massó, Agnès
Delgado Garcia, José M.
Figueras Retuerta, Francesc
Gratacós Solsona, Eduard
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malnutrició
Retard del creixement intrauterí
Neonatologia
Models animals en la investigació
Malnutrition
Fetal growth retardation
Neonatology
Animal models in research
topic Malnutrició
Retard del creixement intrauterí
Neonatologia
Models animals en la investigació
Malnutrition
Fetal growth retardation
Neonatology
Animal models in research
description Introduction: Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of the neurodevelopmental effects of both situations in pregnant rabbits was performed. Materials and Methods: The placental underperfusion model was induced after uteroplacental vessel ligation at 25 days of pregnancy. The undernutrition model was induced after a reduction of 70% of the basal maternal intake at 22 days of pregnancy. Neurobehavioral tests were applied in the derived offspring at the neonatal period and over the long term. Structural brain differences were evaluated by brain networks obtained from diffusion magnetic resonance imaging. Results: Birth weight was significantly lower in both cases. However, stillbirth was only increased in the placental underperfusion model. Cases from both models presented poorer neurobehavioral performance and network infrastructure, being more pro-nounced in the placental underperfusion model. Discussion: Prenatal insults during the last third of gestation resulted in functional and structural disturbances. The degree of neurodevelopmental impairment and its association with structural brain reorganization seemed to be related to the type of the prenatal insult, showing stronger effects in the placental underperfusion model. (C) 2017 S. Karger AG, Basel
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125371
url https://hdl.handle.net/2445/125371
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1159/000454859
Fetal Diagnosis and Therapy, 2017, vol. 42, num. 3, p. 189-197
https://doi.org/10.1159/000454859
dc.rights.none.fl_str_mv (c) Karger, 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Karger, 2017
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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