Safer-by-design flame-sprayed silicon dioxide nanoparticles

Background: Amorphous silica nanoparticles (SiO2 NPs) have been regarded as relatively benign nanomaterials, however, this widely held opinion has been questioned in recent years by several reports on in vitro and in vivo toxicity. Surface chemistry, more specifically the surface silanol content, ha...

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Autores: Rubio Lorente, Laura|||0000-0002-2088-3803, Pyrgiotakis, Georgios, Beltran-Huarac, Juan, Zhang, Yipei, Gaurav, Joshi, Deloid, Glen, Spyrogianni, Anastasia, Sarosiek, Kristopher A., Bello, Dhimiter, Demokritou, Philip
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:325676
Acceso en línea:https://ddd.uab.cat/record/325676
https://dx.doi.org/urn:doi:10.1186/s12989-019-0325-1
Access Level:acceso abierto
Palabra clave:Amorphous silica
Flame spray pyrolysis
Silanol groups
Surface reactivity
Toxicity
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spelling Safer-by-design flame-sprayed silicon dioxide nanoparticlesThe role of silanol content on ROS generation, surface activity and cytotoxicityRubio Lorente, Laura|||0000-0002-2088-3803Pyrgiotakis, GeorgiosBeltran-Huarac, JuanZhang, YipeiGaurav, JoshiDeloid, GlenSpyrogianni, AnastasiaSarosiek, Kristopher A.Bello, DhimiterDemokritou, PhilipAmorphous silicaFlame spray pyrolysisSilanol groupsSurface reactivityToxicityBackground: Amorphous silica nanoparticles (SiO2 NPs) have been regarded as relatively benign nanomaterials, however, this widely held opinion has been questioned in recent years by several reports on in vitro and in vivo toxicity. Surface chemistry, more specifically the surface silanol content, has been identified as an important toxicity modulator for SiO2 NPs. Here, quantitative relationships between the silanol content on SiO2 NPs, free radical generation and toxicity have been identified, with the purpose of synthesizing safer-by-design fumed silica nanoparticles. Results: Consistent and statistically significant trends were seen between the total silanol content, cell membrane damage, and cell viability, but not with intracellular reactive oxygen species (ROS), in the macrophages RAW264.7. SiO2 NPs with lower total silanol content exhibited larger adverse cellular effects. The SAEC epithelial cell line did not show any sign of toxicity by any of the nanoparticles. Free radical generation and surface reactivity of these nanoparticles were also influenced by the temperature of combustion and total silanol content. Conclusion: Surface silanol content plays an important role in cellular toxicity and surface reactivity, although it might not be the sole factor influencing fumed silica NP toxicity. It was demonstrated that synthesis conditions for SiO2 NPs influence the type and quantity of free radicals, oxidative stress, nanoparticle interaction with the biological milieu they come in contact with, and determine the specific mechanisms of toxicity. We demonstrate here that it is possible to produce much less toxic fumed silicas by modulating the synthesis conditions. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/325676https://dx.doi.org/urn:doi:10.1186/s12989-019-0325-1reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3256762026-06-06T12:50:31Z
dc.title.none.fl_str_mv Safer-by-design flame-sprayed silicon dioxide nanoparticles
The role of silanol content on ROS generation, surface activity and cytotoxicity
title Safer-by-design flame-sprayed silicon dioxide nanoparticles
spellingShingle Safer-by-design flame-sprayed silicon dioxide nanoparticles
Rubio Lorente, Laura|||0000-0002-2088-3803
Amorphous silica
Flame spray pyrolysis
Silanol groups
Surface reactivity
Toxicity
title_short Safer-by-design flame-sprayed silicon dioxide nanoparticles
title_full Safer-by-design flame-sprayed silicon dioxide nanoparticles
title_fullStr Safer-by-design flame-sprayed silicon dioxide nanoparticles
title_full_unstemmed Safer-by-design flame-sprayed silicon dioxide nanoparticles
title_sort Safer-by-design flame-sprayed silicon dioxide nanoparticles
dc.creator.none.fl_str_mv Rubio Lorente, Laura|||0000-0002-2088-3803
Pyrgiotakis, Georgios
Beltran-Huarac, Juan
Zhang, Yipei
Gaurav, Joshi
Deloid, Glen
Spyrogianni, Anastasia
Sarosiek, Kristopher A.
Bello, Dhimiter
Demokritou, Philip
author Rubio Lorente, Laura|||0000-0002-2088-3803
author_facet Rubio Lorente, Laura|||0000-0002-2088-3803
Pyrgiotakis, Georgios
Beltran-Huarac, Juan
Zhang, Yipei
Gaurav, Joshi
Deloid, Glen
Spyrogianni, Anastasia
Sarosiek, Kristopher A.
Bello, Dhimiter
Demokritou, Philip
author_role author
author2 Pyrgiotakis, Georgios
Beltran-Huarac, Juan
Zhang, Yipei
Gaurav, Joshi
Deloid, Glen
Spyrogianni, Anastasia
Sarosiek, Kristopher A.
Bello, Dhimiter
Demokritou, Philip
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Amorphous silica
Flame spray pyrolysis
Silanol groups
Surface reactivity
Toxicity
topic Amorphous silica
Flame spray pyrolysis
Silanol groups
Surface reactivity
Toxicity
description Background: Amorphous silica nanoparticles (SiO2 NPs) have been regarded as relatively benign nanomaterials, however, this widely held opinion has been questioned in recent years by several reports on in vitro and in vivo toxicity. Surface chemistry, more specifically the surface silanol content, has been identified as an important toxicity modulator for SiO2 NPs. Here, quantitative relationships between the silanol content on SiO2 NPs, free radical generation and toxicity have been identified, with the purpose of synthesizing safer-by-design fumed silica nanoparticles. Results: Consistent and statistically significant trends were seen between the total silanol content, cell membrane damage, and cell viability, but not with intracellular reactive oxygen species (ROS), in the macrophages RAW264.7. SiO2 NPs with lower total silanol content exhibited larger adverse cellular effects. The SAEC epithelial cell line did not show any sign of toxicity by any of the nanoparticles. Free radical generation and surface reactivity of these nanoparticles were also influenced by the temperature of combustion and total silanol content. Conclusion: Surface silanol content plays an important role in cellular toxicity and surface reactivity, although it might not be the sole factor influencing fumed silica NP toxicity. It was demonstrated that synthesis conditions for SiO2 NPs influence the type and quantity of free radicals, oxidative stress, nanoparticle interaction with the biological milieu they come in contact with, and determine the specific mechanisms of toxicity. We demonstrate here that it is possible to produce much less toxic fumed silicas by modulating the synthesis conditions.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/325676
https://dx.doi.org/urn:doi:10.1186/s12989-019-0325-1
url https://ddd.uab.cat/record/325676
https://dx.doi.org/urn:doi:10.1186/s12989-019-0325-1
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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