Iron deficiency without anemia: indications for treatment

Background and Purpose: Iron deficiency without anemia (IDWA) is the predominant form of iron deficiency (ID). In IDWA a negative iron balance reduces the iron stores responsible for keeping the hemoglobin concentration stable. The medical consequences of IDWA and the need for treatment of the condi...

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Detalles Bibliográficos
Autores: Castelo-Branco Flores, Camil, Quintas, Lara
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/177901
Acceso en línea:https://hdl.handle.net/2445/177901
Access Level:acceso abierto
Palabra clave:Dèficit de ferro
Hematologia
Iron deficiency diseases
Hematology
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spelling Iron deficiency without anemia: indications for treatmentCastelo-Branco Flores, CamilQuintas, LaraDèficit de ferroHematologiaIron deficiency diseasesHematologyBackground and Purpose: Iron deficiency without anemia (IDWA) is the predominant form of iron deficiency (ID). In IDWA a negative iron balance reduces the iron stores responsible for keeping the hemoglobin concentration stable. The medical consequences of IDWA and the need for treatment of the condition are debated. Methods: An electronic-based search was performed using the Embase, Ovid Medline and and Cochrane library databases. The following medical subject heading (MeSH) terms, keywords and their combinations were used: 'iron deficiency', 'oral iron',' iron supplements', 'anemia', 'iron deficiency without anemia' and 'iron adverse events'. Results: Mounting evidence suggests that even mild ID (serum ferritin <20-35 ug/L) can result in symptoms such as fatigue, altered cognitive functions, decreased aerobic performance, restless legs syndrome, reduced quality of sleep, and so on. Individuals, especially from the well-known risk groups such as growing children, menstruating and pregnant women, but also endurance athletes and the elderly, frequently develop mild forms of ID. Current evidence strongly indicates that to ensure optimal health and development, it is important to prevent and treat even mild ID through iron supplementation. Treatment with oral ferrous iron preparations is known to be effective and safe in most patients. Despite much progress also with parenteral iron preparations, oral iron therapy is clearly the first-line treatment in all subjects with diagnosed ID. Conclusions: IDWA is an under-recognized, underdiagnosed and certainly undertreated entity. The balance of current evidence strongly indicates that to ensure optimal health and development, it is important to prevent and treat even mild ID.Biomedical Technologies2020info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/177901Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publication a: https://gremjournal.com/journal/04-2020/iron-deficiency-without-anemia-indications-for-treatment/Gynecological and Reproductive Endocrinology and Metabolism , 2020, vol. 1, num. 4, p. 215-222cc-by-nc-nd, 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1779012026-05-27T06:46:51Z
dc.title.none.fl_str_mv Iron deficiency without anemia: indications for treatment
title Iron deficiency without anemia: indications for treatment
spellingShingle Iron deficiency without anemia: indications for treatment
Castelo-Branco Flores, Camil
Dèficit de ferro
Hematologia
Iron deficiency diseases
Hematology
title_short Iron deficiency without anemia: indications for treatment
title_full Iron deficiency without anemia: indications for treatment
title_fullStr Iron deficiency without anemia: indications for treatment
title_full_unstemmed Iron deficiency without anemia: indications for treatment
title_sort Iron deficiency without anemia: indications for treatment
dc.creator.none.fl_str_mv Castelo-Branco Flores, Camil
Quintas, Lara
author Castelo-Branco Flores, Camil
author_facet Castelo-Branco Flores, Camil
Quintas, Lara
author_role author
author2 Quintas, Lara
author2_role author
dc.subject.none.fl_str_mv Dèficit de ferro
Hematologia
Iron deficiency diseases
Hematology
topic Dèficit de ferro
Hematologia
Iron deficiency diseases
Hematology
description Background and Purpose: Iron deficiency without anemia (IDWA) is the predominant form of iron deficiency (ID). In IDWA a negative iron balance reduces the iron stores responsible for keeping the hemoglobin concentration stable. The medical consequences of IDWA and the need for treatment of the condition are debated. Methods: An electronic-based search was performed using the Embase, Ovid Medline and and Cochrane library databases. The following medical subject heading (MeSH) terms, keywords and their combinations were used: 'iron deficiency', 'oral iron',' iron supplements', 'anemia', 'iron deficiency without anemia' and 'iron adverse events'. Results: Mounting evidence suggests that even mild ID (serum ferritin <20-35 ug/L) can result in symptoms such as fatigue, altered cognitive functions, decreased aerobic performance, restless legs syndrome, reduced quality of sleep, and so on. Individuals, especially from the well-known risk groups such as growing children, menstruating and pregnant women, but also endurance athletes and the elderly, frequently develop mild forms of ID. Current evidence strongly indicates that to ensure optimal health and development, it is important to prevent and treat even mild ID through iron supplementation. Treatment with oral ferrous iron preparations is known to be effective and safe in most patients. Despite much progress also with parenteral iron preparations, oral iron therapy is clearly the first-line treatment in all subjects with diagnosed ID. Conclusions: IDWA is an under-recognized, underdiagnosed and certainly undertreated entity. The balance of current evidence strongly indicates that to ensure optimal health and development, it is important to prevent and treat even mild ID.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/177901
url https://hdl.handle.net/2445/177901
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publication a: https://gremjournal.com/journal/04-2020/iron-deficiency-without-anemia-indications-for-treatment/
Gynecological and Reproductive Endocrinology and Metabolism , 2020, vol. 1, num. 4, p. 215-222
dc.rights.none.fl_str_mv cc-by-nc-nd, 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd, 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Biomedical Technologies
publisher.none.fl_str_mv Biomedical Technologies
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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