Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb

Introduction: Neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case Report: We report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-...

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Autores: Del Barrio, BV, Maya-Enero, S, Rodriguez-Sevilla, JJ, Suris, CC, Llobet, AB, Lopez-Vilchez, MA
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p5759
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5759
Access Level:acceso abierto
Palabra clave:Neonatal alloimmune neutropenia
Neonatal isoimmune neutropenia
Anti-neutrophil antibodies
Fc&#947
receptor IIIb
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spelling Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIbDel Barrio, BVMaya-Enero, SRodriguez-Sevilla, JJSuris, CCLlobet, ABLopez-Vilchez, MANeonatal alloimmune neutropeniaNeonatal isoimmune neutropeniaAnti-neutrophil antibodiesFc&#947receptor IIIbIntroduction: Neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case Report: We report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-1a, 1b, and 1c, consistent with an Fc gamma RIIIb deficiency. The father was 1(a+b+c-) and the neonates were 1(a-b+c-). A strongly positive result was observed in the granulocyte immunofluorescence test against paternal neutrophils (IgG antibodies). IgG anti-CD16b isoantibodies were detected in the mother's breast milk. Neutropenia resolved after 28 days without requiring any specific treatments. Discussion: Even though neonatal alloimmune neutropenia (NAN) is usually benign and self-limiting, some patients pre-sent with delayed separation of the umbilical cord, mild skin infections, omphalitis, or severe infections like pneumonia, sepsis, and meningitis. Thus, it is important to rule out NAN in case of neonatal neutropenia.KARGER2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5759TRANSFUSION MEDICINE AND HEMOTHERAPYISSN: 16603796ISSNe: 16603818reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p57592026-06-14T12:41:47Z
dc.title.none.fl_str_mv Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
title Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
spellingShingle Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
Del Barrio, BV
Neonatal alloimmune neutropenia
Neonatal isoimmune neutropenia
Anti-neutrophil antibodies
Fc&#947
receptor IIIb
title_short Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
title_full Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
title_fullStr Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
title_full_unstemmed Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
title_sort Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
dc.creator.none.fl_str_mv Del Barrio, BV
Maya-Enero, S
Rodriguez-Sevilla, JJ
Suris, CC
Llobet, AB
Lopez-Vilchez, MA
author Del Barrio, BV
author_facet Del Barrio, BV
Maya-Enero, S
Rodriguez-Sevilla, JJ
Suris, CC
Llobet, AB
Lopez-Vilchez, MA
author_role author
author2 Maya-Enero, S
Rodriguez-Sevilla, JJ
Suris, CC
Llobet, AB
Lopez-Vilchez, MA
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Neonatal alloimmune neutropenia
Neonatal isoimmune neutropenia
Anti-neutrophil antibodies
Fc&#947
receptor IIIb
topic Neonatal alloimmune neutropenia
Neonatal isoimmune neutropenia
Anti-neutrophil antibodies
Fc&#947
receptor IIIb
description Introduction: Neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case Report: We report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-1a, 1b, and 1c, consistent with an Fc gamma RIIIb deficiency. The father was 1(a+b+c-) and the neonates were 1(a-b+c-). A strongly positive result was observed in the granulocyte immunofluorescence test against paternal neutrophils (IgG antibodies). IgG anti-CD16b isoantibodies were detected in the mother's breast milk. Neutropenia resolved after 28 days without requiring any specific treatments. Discussion: Even though neonatal alloimmune neutropenia (NAN) is usually benign and self-limiting, some patients pre-sent with delayed separation of the umbilical cord, mild skin infections, omphalitis, or severe infections like pneumonia, sepsis, and meningitis. Thus, it is important to rule out NAN in case of neonatal neutropenia.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5759
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5759
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv KARGER
publisher.none.fl_str_mv KARGER
dc.source.none.fl_str_mv TRANSFUSION MEDICINE AND HEMOTHERAPY
ISSN: 16603796
ISSNe: 16603818
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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