Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis

(1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper fea...

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Autores: López Soley, Elisabet, Martinez Heras, Eloy, Andorra, Magi, Solanes, Aleix, Radua, Joaquim, Montejo González, Carmen, Alba Arbalat, Salut, Sola Valls, Nuria, Pulido Valdeolivas, Irene, Sepulveda, Maria, Romero Pinel, Lucía María, Munteis, Elvira, Martínez Rodríguez, José Enrique, Blanco, Yolanda, Martinez Lapiscina, Elena H., Villoslada, Pablo, Saiz Hinarejos, Albert, Solana Díaz, Elisabeth, Llufriu Duran, Sara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/181843
Acceso en línea:https://hdl.handle.net/2445/181843
Access Level:acceso abierto
Palabra clave:Esclerosi múltiple
Cognició
Multiple sclerosis
Cognition
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spelling Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple SclerosisLópez Soley, ElisabetMartinez Heras, EloyAndorra, MagiSolanes, AleixRadua, JoaquimMontejo González, CarmenAlba Arbalat, SalutSola Valls, NuriaPulido Valdeolivas, IreneSepulveda, MariaRomero Pinel, Lucía MaríaMunteis, ElviraMartínez Rodríguez, José EnriqueBlanco, YolandaMartinez Lapiscina, Elena H.Villoslada, PabloSaiz Hinarejos, AlbertSolana Díaz, ElisabethLlufriu Duran, SaraEsclerosi múltipleCognicióMultiple sclerosisCognition(1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper features a longitudinal study with 212 patients who underwent several cognitive examinations at different time points. Dynamics of cognition were assessed using mixed-effects linear spline models. Machine learning techniques were used to identify which baseline demographic, clinical, and neuroimaging measures best predicted CI. (3) Results: In the first 5 years of MS, we detected an increase in the z-scores of global cognition, verbal memory, and information processing speed, which was followed by a decline in global cognition and memory (p < 0.05) between years 5 and 15. From 15 to 30 years of disease onset, cognitive decline continued, affecting global cognition and verbal memory. The baseline measures that best predicted CI were education, disease severity, lesion burden, and hippocampus and anterior cingulate cortex volume. (4) Conclusions: In MS, cognition deteriorates 5 years after disease onset, declining steadily over the next 25 years and more markedly affecting verbal memory. Education, disease severity, lesion burden, and volume of limbic structures predict future CI and may be helpful when identifying at-risk patients.MDPI AG2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/181843Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jpm11111107Journal of Personalized Medicine, 2021, vol. 11, num. 11, p. 1107https://doi.org/10.3390/jpm11111107cc by (c) Lopez Soley, Elisabet et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1818432026-05-27T06:46:51Z
dc.title.none.fl_str_mv Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
title Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
spellingShingle Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
López Soley, Elisabet
Esclerosi múltiple
Cognició
Multiple sclerosis
Cognition
title_short Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
title_full Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
title_fullStr Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
title_full_unstemmed Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
title_sort Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
dc.creator.none.fl_str_mv López Soley, Elisabet
Martinez Heras, Eloy
Andorra, Magi
Solanes, Aleix
Radua, Joaquim
Montejo González, Carmen
Alba Arbalat, Salut
Sola Valls, Nuria
Pulido Valdeolivas, Irene
Sepulveda, Maria
Romero Pinel, Lucía María
Munteis, Elvira
Martínez Rodríguez, José Enrique
Blanco, Yolanda
Martinez Lapiscina, Elena H.
Villoslada, Pablo
Saiz Hinarejos, Albert
Solana Díaz, Elisabeth
Llufriu Duran, Sara
author López Soley, Elisabet
author_facet López Soley, Elisabet
Martinez Heras, Eloy
Andorra, Magi
Solanes, Aleix
Radua, Joaquim
Montejo González, Carmen
Alba Arbalat, Salut
Sola Valls, Nuria
Pulido Valdeolivas, Irene
Sepulveda, Maria
Romero Pinel, Lucía María
Munteis, Elvira
Martínez Rodríguez, José Enrique
Blanco, Yolanda
Martinez Lapiscina, Elena H.
Villoslada, Pablo
Saiz Hinarejos, Albert
Solana Díaz, Elisabeth
Llufriu Duran, Sara
author_role author
author2 Martinez Heras, Eloy
Andorra, Magi
Solanes, Aleix
Radua, Joaquim
Montejo González, Carmen
Alba Arbalat, Salut
Sola Valls, Nuria
Pulido Valdeolivas, Irene
Sepulveda, Maria
Romero Pinel, Lucía María
Munteis, Elvira
Martínez Rodríguez, José Enrique
Blanco, Yolanda
Martinez Lapiscina, Elena H.
Villoslada, Pablo
Saiz Hinarejos, Albert
Solana Díaz, Elisabeth
Llufriu Duran, Sara
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Esclerosi múltiple
Cognició
Multiple sclerosis
Cognition
topic Esclerosi múltiple
Cognició
Multiple sclerosis
Cognition
description (1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper features a longitudinal study with 212 patients who underwent several cognitive examinations at different time points. Dynamics of cognition were assessed using mixed-effects linear spline models. Machine learning techniques were used to identify which baseline demographic, clinical, and neuroimaging measures best predicted CI. (3) Results: In the first 5 years of MS, we detected an increase in the z-scores of global cognition, verbal memory, and information processing speed, which was followed by a decline in global cognition and memory (p < 0.05) between years 5 and 15. From 15 to 30 years of disease onset, cognitive decline continued, affecting global cognition and verbal memory. The baseline measures that best predicted CI were education, disease severity, lesion burden, and hippocampus and anterior cingulate cortex volume. (4) Conclusions: In MS, cognition deteriorates 5 years after disease onset, declining steadily over the next 25 years and more markedly affecting verbal memory. Education, disease severity, lesion burden, and volume of limbic structures predict future CI and may be helpful when identifying at-risk patients.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181843
url https://hdl.handle.net/2445/181843
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jpm11111107
Journal of Personalized Medicine, 2021, vol. 11, num. 11, p. 1107
https://doi.org/10.3390/jpm11111107
dc.rights.none.fl_str_mv cc by (c) Lopez Soley, Elisabet et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Lopez Soley, Elisabet et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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