Impact of multidrug resistance on the virulence and fitness of Pseudomonas aeruginosa: a microbiological and clinical perspective
Pseudomonas aeruginosa is one of the most common nosocomial pathogens and part of the top emergent species associated with antimicrobial resistance that has become one of the greatest threat to public health in the twenty-first century. This bacterium is provided with a wide set of virulence factors...
| Autores: | , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2024 |
| País: | España |
| Recursos: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositório: | Docusalut |
| Idioma: | inglês |
| OAI Identifier: | oai:docusalut.com:20.500.13003/20599 |
| Acesso em linha: | https://hdl.handle.net/20.500.13003/20599 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Anti-Bacterial Agents / pharmacology Anti-Bacterial Agents / therapeutic use Drug Resistance, Multiple, Bacterial* / genetics Humans Pseudomonas Infections* / drug therapy Pseudomonas Infections* / microbiology Pseudomonas aeruginosa* / drug effects Pseudomonas aeruginosa* / genetics Pseudomonas aeruginosa* / pathogenicity Virulence Virulence Factors / genetics Humanos Virulencia |
| Resumo: | Pseudomonas aeruginosa is one of the most common nosocomial pathogens and part of the top emergent species associated with antimicrobial resistance that has become one of the greatest threat to public health in the twenty-first century. This bacterium is provided with a wide set of virulence factors that contribute to pathogenesis in acute and chronic infections. This review aims to summarize the impact of multidrug resistance on the virulence and fitness of P. aeruginosa. Although it is generally assumed that acquisition of resistant determinants is associated with a fitness cost, several studies support that resistance mutations may not be associated with a decrease in virulence and/or that certain compensatory mutations may allow multidrug resistance strains to recover their initial fitness. We discuss the interplay between resistance profiles and virulence from a microbiological perspective but also the clinical consequences in outcomes and the economic impact. |
|---|