Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder identified by hematological abnormalities including anemia, leukopenia, and thrombocytopenia. Complement system disturbance is implicated in the pathogenesis of SLE. In this work, we aim to study how a full assessment of the complem...

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Autores: Fernández-Cladera Y., García-González M., Hernández-Díaz M., Gómez-Bernal F., Quevedo-Abeledo J.C., González-Rivero, Agustín F., Vera-González, Antonia de, Gómez-Moreno, Cristina, González-Gay Mantecón, Miguel Ángel, Ferraz-Amaro, Iván
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/34196
Acceso en línea:https://hdl.handle.net/10902/34196
Access Level:acceso abierto
Palabra clave:Complement system
Systemic lupus erythematosus
Blood cells count
Hemoglobin
Leucocytes
Neutrophils
Monocytes
Lymphocytes
Platelets
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spelling Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosusFernández-Cladera Y.García-González M.Hernández-Díaz M.Gómez-Bernal F.Quevedo-Abeledo J.C.González-Rivero, Agustín F.Vera-González, Antonia deGómez-Moreno, CristinaGonzález-Gay Mantecón, Miguel ÁngelFerraz-Amaro, IvánComplement systemSystemic lupus erythematosusBlood cells countHemoglobinLeucocytesNeutrophilsMonocytesLymphocytesPlateletsSystemic lupus erythematosus (SLE) is a chronic autoimmune disorder identified by hematological abnormalities including anemia, leukopenia, and thrombocytopenia. Complement system disturbance is implicated in the pathogenesis of SLE. In this work, we aim to study how a full assessment of the complement system, which includes the evaluation of its three pathways, relates to blood cell counts in a population of patients with SLE. New-generation functional assays of the classical, alternative, and lectin pathways of the complement system were conducted in 284 patients with SLE. Additionally, serum levels of inactive molecules (C1q, C2, C3, C4, factor D) and activated molecules (C3a), as well as regulators (C1-inhibitor and factor H), were evaluated. Complete blood cell counts were analyzed. Multivariable linear regression analysis was performed to study the relationship of hematological profiles with this full characterization of the complement system. After multivariable adjustments that included age, sex, SLICC-DI (damage), and SLEDAI (activity) scores, as well as the use of aspirin, prednisone, methotrexate, azathioprine, and mycophenolate mofetil, several relationships were observed between the C pathways and the individual products and blood cells profile. Lower values of C1q and C2 were associated with lower hemoglobin levels. Lower leukocyte counts showed significantly lower values of C4, C1 inhibitor, C3, factor D, and alternative pathway functional levels. Neutrophil counts showed significant negative relationships only with the alternative pathway and C1-inh. In the case of lymphocytes, associations were found, especially with functional tests of the classical and alternative pathways, as well as with C2, C4, C3, and C3a. On the contrary, for platelets, significance was only observed, after multivariable adjustment, with lower C2 concentrations. In conclusion, the serum complement system and hematological profile in SLE are independently linked, after adjustment for disease activity and damage. These relationships are basically negative and are predominantly found in lymphocytes.Funding: This study was funded by a grant to I.F.-A. by Instituto de Salud Carlos III (ISCIII) through the project PI20/00084 and co-funded by the European UnionMDPI AGUniversidad de Cantabria20242024-04-27journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/34196Biomedicines, 2024, 27, 12(5), 967reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/341962026-06-02T12:39:31Z
dc.title.none.fl_str_mv Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus
title Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus
spellingShingle Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus
Fernández-Cladera Y.
Complement system
Systemic lupus erythematosus
Blood cells count
Hemoglobin
Leucocytes
Neutrophils
Monocytes
Lymphocytes
Platelets
title_short Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus
title_full Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus
title_fullStr Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus
title_full_unstemmed Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus
title_sort Relationship of hematological profiles with the serum complement system in patients with systemic Lupus erythematosus
dc.creator.none.fl_str_mv Fernández-Cladera Y.
García-González M.
Hernández-Díaz M.
Gómez-Bernal F.
Quevedo-Abeledo J.C.
González-Rivero, Agustín F.
Vera-González, Antonia de
Gómez-Moreno, Cristina
González-Gay Mantecón, Miguel Ángel
Ferraz-Amaro, Iván
author Fernández-Cladera Y.
author_facet Fernández-Cladera Y.
García-González M.
Hernández-Díaz M.
Gómez-Bernal F.
Quevedo-Abeledo J.C.
González-Rivero, Agustín F.
Vera-González, Antonia de
Gómez-Moreno, Cristina
González-Gay Mantecón, Miguel Ángel
Ferraz-Amaro, Iván
author_role author
author2 García-González M.
Hernández-Díaz M.
Gómez-Bernal F.
Quevedo-Abeledo J.C.
González-Rivero, Agustín F.
Vera-González, Antonia de
Gómez-Moreno, Cristina
González-Gay Mantecón, Miguel Ángel
Ferraz-Amaro, Iván
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Complement system
Systemic lupus erythematosus
Blood cells count
Hemoglobin
Leucocytes
Neutrophils
Monocytes
Lymphocytes
Platelets
topic Complement system
Systemic lupus erythematosus
Blood cells count
Hemoglobin
Leucocytes
Neutrophils
Monocytes
Lymphocytes
Platelets
description Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder identified by hematological abnormalities including anemia, leukopenia, and thrombocytopenia. Complement system disturbance is implicated in the pathogenesis of SLE. In this work, we aim to study how a full assessment of the complement system, which includes the evaluation of its three pathways, relates to blood cell counts in a population of patients with SLE. New-generation functional assays of the classical, alternative, and lectin pathways of the complement system were conducted in 284 patients with SLE. Additionally, serum levels of inactive molecules (C1q, C2, C3, C4, factor D) and activated molecules (C3a), as well as regulators (C1-inhibitor and factor H), were evaluated. Complete blood cell counts were analyzed. Multivariable linear regression analysis was performed to study the relationship of hematological profiles with this full characterization of the complement system. After multivariable adjustments that included age, sex, SLICC-DI (damage), and SLEDAI (activity) scores, as well as the use of aspirin, prednisone, methotrexate, azathioprine, and mycophenolate mofetil, several relationships were observed between the C pathways and the individual products and blood cells profile. Lower values of C1q and C2 were associated with lower hemoglobin levels. Lower leukocyte counts showed significantly lower values of C4, C1 inhibitor, C3, factor D, and alternative pathway functional levels. Neutrophil counts showed significant negative relationships only with the alternative pathway and C1-inh. In the case of lymphocytes, associations were found, especially with functional tests of the classical and alternative pathways, as well as with C2, C4, C3, and C3a. On the contrary, for platelets, significance was only observed, after multivariable adjustment, with lower C2 concentrations. In conclusion, the serum complement system and hematological profile in SLE are independently linked, after adjustment for disease activity and damage. These relationships are basically negative and are predominantly found in lymphocytes.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-04-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/34196
url https://hdl.handle.net/10902/34196
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Biomedicines, 2024, 27, 12(5), 967
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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