Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain

We conducted the present study to determine the incidence of disease flares (relapses and recurrences) in a series of patients with biopsy-proven giant cell arteritis (GCA). We assessed a series of 174 patients who were diagnosed with biopsy-proven GCA, uniformly treated, and followed at the rheumat...

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Autores: Martínez-Lado, Luciana, Calviño-Díaz, Carolina, Piñeiro, Ángela, Dierssen Sotos, Trinidad, Vázquez-Rodríguez, Tomás, Miranda-Filloy, López-Díaz, Miranda, Blanco Alonso, Ricardo|||0000-0003-2344-2285, Llorca Díaz, Francisco Javier|||0000-0001-8569-861X, González-Gay Mantecón, Miguel Ángel
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/29156
Acceso en línea:https://hdl.handle.net/10902/29156
Access Level:acceso abierto
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spelling Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern SpainMartínez-Lado, LucianaCalviño-Díaz, CarolinaPiñeiro, ÁngelaDierssen Sotos, TrinidadVázquez-Rodríguez, TomásMiranda-FilloyLópez-Díaz, MirandaBlanco Alonso, Ricardo|||0000-0003-2344-2285Llorca Díaz, Francisco Javier|||0000-0001-8569-861XGonzález-Gay Mantecón, Miguel ÁngelWe conducted the present study to determine the incidence of disease flares (relapses and recurrences) in a series of patients with biopsy-proven giant cell arteritis (GCA). We assessed a series of 174 patients who were diagnosed with biopsy-proven GCA, uniformly treated, and followed at the rheumatology division of Hospital Xeral-Calde (Lugo, Spain), the single rheumatology division for a well-defined population. All of them were followed for at least 1 year after the disease diagnosis. Seventy-one (40.8%) experienced relapses or recurrences of the disease. Patients who had relapses or recurrences did not show clinical differences when compared with the remaining biopsy-proven GCA patients. However, the total duration of corticosteroid therapy was significantly longer in those patients who had relapses or recurrences of the disease. The median dose of prednisone and the median duration of corticosteroid treatment at the time of the first relapse were 5 mg/d and 16 months, respectively. Headache (52%) was the most common feature at the time of the first relapse. Polymyalgia rheumatica manifestations occurred in 30% of the patients at that time. However, none of them developed visual loss. Thirty-two patients experienced recurrences of the disease when prednisone dose had been discontinued. The median time from the disease diagnosis to the time of the recurrence was 23 months. The presence of anemia (hemoglobin <12 g/dL) at the time of disease diagnosis was the best predictor of relapses or recurrences of GCA (odds ratio, 2.17; 95% confidence interval, 1.02-4.62; p = 0.04). The results from the present study confirm that relapses and recurrences are frequent in homogenously treated patients with biopsy-proven GCA. A chronic inflammatory response manifested by anemia at the time of disease diagnosis may predict the development of disease flares.Lippincott Williams & WilkinsUniversidad de Cantabria20112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/29156Medicine Volume 90, Number 3, May 2011reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/291562026-06-02T12:39:31Z
dc.title.none.fl_str_mv Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain
title Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain
spellingShingle Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain
Martínez-Lado, Luciana
title_short Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain
title_full Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain
title_fullStr Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain
title_full_unstemmed Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain
title_sort Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain
dc.creator.none.fl_str_mv Martínez-Lado, Luciana
Calviño-Díaz, Carolina
Piñeiro, Ángela
Dierssen Sotos, Trinidad
Vázquez-Rodríguez, Tomás
Miranda-Filloy
López-Díaz, Miranda
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
González-Gay Mantecón, Miguel Ángel
author Martínez-Lado, Luciana
author_facet Martínez-Lado, Luciana
Calviño-Díaz, Carolina
Piñeiro, Ángela
Dierssen Sotos, Trinidad
Vázquez-Rodríguez, Tomás
Miranda-Filloy
López-Díaz, Miranda
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
González-Gay Mantecón, Miguel Ángel
author_role author
author2 Calviño-Díaz, Carolina
Piñeiro, Ángela
Dierssen Sotos, Trinidad
Vázquez-Rodríguez, Tomás
Miranda-Filloy
López-Díaz, Miranda
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
González-Gay Mantecón, Miguel Ángel
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
description We conducted the present study to determine the incidence of disease flares (relapses and recurrences) in a series of patients with biopsy-proven giant cell arteritis (GCA). We assessed a series of 174 patients who were diagnosed with biopsy-proven GCA, uniformly treated, and followed at the rheumatology division of Hospital Xeral-Calde (Lugo, Spain), the single rheumatology division for a well-defined population. All of them were followed for at least 1 year after the disease diagnosis. Seventy-one (40.8%) experienced relapses or recurrences of the disease. Patients who had relapses or recurrences did not show clinical differences when compared with the remaining biopsy-proven GCA patients. However, the total duration of corticosteroid therapy was significantly longer in those patients who had relapses or recurrences of the disease. The median dose of prednisone and the median duration of corticosteroid treatment at the time of the first relapse were 5 mg/d and 16 months, respectively. Headache (52%) was the most common feature at the time of the first relapse. Polymyalgia rheumatica manifestations occurred in 30% of the patients at that time. However, none of them developed visual loss. Thirty-two patients experienced recurrences of the disease when prednisone dose had been discontinued. The median time from the disease diagnosis to the time of the recurrence was 23 months. The presence of anemia (hemoglobin <12 g/dL) at the time of disease diagnosis was the best predictor of relapses or recurrences of GCA (odds ratio, 2.17; 95% confidence interval, 1.02-4.62; p = 0.04). The results from the present study confirm that relapses and recurrences are frequent in homogenously treated patients with biopsy-proven GCA. A chronic inflammatory response manifested by anemia at the time of disease diagnosis may predict the development of disease flares.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/29156
url https://hdl.handle.net/10902/29156
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv Medicine Volume 90, Number 3, May 2011
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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