Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD
MPOC; Tabaquisme
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/7235 |
| Acceso en línea: | https://hdl.handle.net/11351/7235 |
| Access Level: | acceso abierto |
| Palabra clave: | Pulmons - Malalties obstructives - Tractament Corticosteroides - Ús terapèutic - Efectes secundaris DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenal Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
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Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPDMiravitlles Fernández, MarcAuladell-Rispau, AriadnaVázquez-Niebla, Juan CarlosMohammed, JibrilNuñez Dubon, Alexa GabrielaMonteagudo, MònicaPulmons - Malalties obstructives - TractamentCorticosteroides - Ús terapèutic - Efectes secundarisDISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic ObstructiveOther subheadings::Other subheadings::Other subheadings::/drug therapyCHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex HormonesOther subheadings::Other subheadings::Other subheadings::/adverse effectsENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónicaOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaCOMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenalOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosMPOC; TabaquismeEPOC; TabaquismoCOPD; SmokingInhaled corticosteroids (ICSs) are indicated for the prevention of exacerbations in COPD; however, a significant proportion of patients at low risk of exacerbations are treated with ICSs. We conducted a systematic review including a diversity of types of study designs and safety outcomes with the objective of describing the risk of adverse effects associated with the long-term use of ICSs in patients with COPD. A total of 90 references corresponding to 83 studies were included, including 26 randomised clinical trials (RCTs), 33 cohort studies, and 24 nested case–control (NCC) studies. Analysis of 19 RCTs showed that exposure to ICSs for ≥1 year increased the risk of pneumonia by 41% (risk ratio 1.41, 95% CI 1.23–1.61). Additionally, cohort and NCC studies showed an association between ICSs and risk of tuberculosis and mycobacterial disease. There was a strong association between ICS use and local disorders such as oral candidiasis and dysphonia. The association between ICSs and the risk of diabetes and fractures was less clear and appeared significant only at high doses of ICSs. Since most patients with COPD are elderly and with frequent comorbidities, an adequate risk–benefit balance is crucial for the indication of ICSs.This study was funded by an unrestricted grant from Boehringer Ingelheim.European Respiratory SocietyInstitut Català de la Salut[Miravitlles M, Nuñez A] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. [Auladell-Rispau A, Vázquez-Niebla JC] Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [Monteagudo M] Primary Care University Research Institute Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Mohammed J] Dept of Physiotherapy, Bayero University, Kano, NigeriaVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/7235Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésEuropean Respiratory Review;30(160)https://doi.org/10.1183/16000617.0075-2021Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/72352026-06-12T09:38:37Z |
| dc.title.none.fl_str_mv |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD |
| title |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD |
| spellingShingle |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD Miravitlles Fernández, Marc Pulmons - Malalties obstructives - Tractament Corticosteroides - Ús terapèutic - Efectes secundaris DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenal Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| title_short |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD |
| title_full |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD |
| title_fullStr |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD |
| title_full_unstemmed |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD |
| title_sort |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD |
| dc.creator.none.fl_str_mv |
Miravitlles Fernández, Marc Auladell-Rispau, Ariadna Vázquez-Niebla, Juan Carlos Mohammed, Jibril Nuñez Dubon, Alexa Gabriela Monteagudo, Mònica |
| author |
Miravitlles Fernández, Marc |
| author_facet |
Miravitlles Fernández, Marc Auladell-Rispau, Ariadna Vázquez-Niebla, Juan Carlos Mohammed, Jibril Nuñez Dubon, Alexa Gabriela Monteagudo, Mònica |
| author_role |
author |
| author2 |
Auladell-Rispau, Ariadna Vázquez-Niebla, Juan Carlos Mohammed, Jibril Nuñez Dubon, Alexa Gabriela Monteagudo, Mònica |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Miravitlles M, Nuñez A] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. [Auladell-Rispau A, Vázquez-Niebla JC] Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [Monteagudo M] Primary Care University Research Institute Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Mohammed J] Dept of Physiotherapy, Bayero University, Kano, Nigeria Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Pulmons - Malalties obstructives - Tractament Corticosteroides - Ús terapèutic - Efectes secundaris DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenal Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| topic |
Pulmons - Malalties obstructives - Tractament Corticosteroides - Ús terapèutic - Efectes secundaris DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenal Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| description |
MPOC; Tabaquisme |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/7235 |
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https://hdl.handle.net/11351/7235 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
European Respiratory Review;30(160) https://doi.org/10.1183/16000617.0075-2021 |
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Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf application/pdf application/pdf application/pdf application/pdf |
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European Respiratory Society |
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European Respiratory Society |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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1869415227639988224 |
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15.81155 |