Non-meiotic chromosome instability in human immature oocytes

Aneuploidy has been a major issue in human gametes and is closely related to fertility problems, as it is known to be present in cleavage stage embryos and gestational losses. Pre-meiotic chromosome abnormalities in women have been previously described. The aim of this study is to assess the whole-c...

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Autores: Daina, G, Ramos, L, Rius, M, Obradors, A, del Rey, J, Giralt, M, Campillo, M, Velilla, E, Pujol, A, Martinez-Pasarell, O, Benet, F, Navarro, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p9017
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9017
Access Level:acceso abierto
Palabra clave:premeiotic instability
immature oocytes
aneuploidy
segmental imbalances
germline mitotic abnormalities
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spelling Non-meiotic chromosome instability in human immature oocytesDaina, GRamos, LRius, MObradors, Adel Rey, JGiralt, MCampillo, MVelilla, EPujol, AMartinez-Pasarell, OBenet, FNavarro, Jpremeiotic instabilityimmature oocytesaneuploidysegmental imbalancesgermline mitotic abnormalitiesAneuploidy has been a major issue in human gametes and is closely related to fertility problems, as it is known to be present in cleavage stage embryos and gestational losses. Pre-meiotic chromosome abnormalities in women have been previously described. The aim of this study is to assess the whole-chromosome complement in immature oocytes to find those abnormalities caused by mitotic instability. For this purpose, a total of 157 oocytes at the germinal vesicle or metaphase I stage, and discarded from IVF cycles, were analysed by CGH. Fifty-six women, between 18 and 45 years old (mean 32.5 years), including 32 IVF patients (25-45 years of age) and 24 IVF oocyte donors (18-33 years of age), were included in the study. A total of 25/157 (15.9%) of the oocytes analysed, obtained from three IVF clinics, contained chromosome abnormalities, including both aneuploidy (24/157) and structural aberrations (9/157). Independently of the maternal age, the incidence of abnormal oocytes which originated before meiosis is 15.9%, and these imbalances were found in 33.9% of the females studied. This work sheds light on the relevance of mitotic instability responsible for the generation of the abnormalities present in human oocytes.NATURE PUBLISHING GROUP2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9017EUROPEAN JOURNAL OF HUMAN GENETICSISSN: 10184813ISSNe: 14765438reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p90172026-06-14T12:41:47Z
dc.title.none.fl_str_mv Non-meiotic chromosome instability in human immature oocytes
title Non-meiotic chromosome instability in human immature oocytes
spellingShingle Non-meiotic chromosome instability in human immature oocytes
Daina, G
premeiotic instability
immature oocytes
aneuploidy
segmental imbalances
germline mitotic abnormalities
title_short Non-meiotic chromosome instability in human immature oocytes
title_full Non-meiotic chromosome instability in human immature oocytes
title_fullStr Non-meiotic chromosome instability in human immature oocytes
title_full_unstemmed Non-meiotic chromosome instability in human immature oocytes
title_sort Non-meiotic chromosome instability in human immature oocytes
dc.creator.none.fl_str_mv Daina, G
Ramos, L
Rius, M
Obradors, A
del Rey, J
Giralt, M
Campillo, M
Velilla, E
Pujol, A
Martinez-Pasarell, O
Benet, F
Navarro, J
author Daina, G
author_facet Daina, G
Ramos, L
Rius, M
Obradors, A
del Rey, J
Giralt, M
Campillo, M
Velilla, E
Pujol, A
Martinez-Pasarell, O
Benet, F
Navarro, J
author_role author
author2 Ramos, L
Rius, M
Obradors, A
del Rey, J
Giralt, M
Campillo, M
Velilla, E
Pujol, A
Martinez-Pasarell, O
Benet, F
Navarro, J
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv premeiotic instability
immature oocytes
aneuploidy
segmental imbalances
germline mitotic abnormalities
topic premeiotic instability
immature oocytes
aneuploidy
segmental imbalances
germline mitotic abnormalities
description Aneuploidy has been a major issue in human gametes and is closely related to fertility problems, as it is known to be present in cleavage stage embryos and gestational losses. Pre-meiotic chromosome abnormalities in women have been previously described. The aim of this study is to assess the whole-chromosome complement in immature oocytes to find those abnormalities caused by mitotic instability. For this purpose, a total of 157 oocytes at the germinal vesicle or metaphase I stage, and discarded from IVF cycles, were analysed by CGH. Fifty-six women, between 18 and 45 years old (mean 32.5 years), including 32 IVF patients (25-45 years of age) and 24 IVF oocyte donors (18-33 years of age), were included in the study. A total of 25/157 (15.9%) of the oocytes analysed, obtained from three IVF clinics, contained chromosome abnormalities, including both aneuploidy (24/157) and structural aberrations (9/157). Independently of the maternal age, the incidence of abnormal oocytes which originated before meiosis is 15.9%, and these imbalances were found in 33.9% of the females studied. This work sheds light on the relevance of mitotic instability responsible for the generation of the abnormalities present in human oocytes.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9017
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9017
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv NATURE PUBLISHING GROUP
publisher.none.fl_str_mv NATURE PUBLISHING GROUP
dc.source.none.fl_str_mv EUROPEAN JOURNAL OF HUMAN GENETICS
ISSN: 10184813
ISSNe: 14765438
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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repository.mail.fl_str_mv
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