Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.

Pancreas outcomes in pancreas after kidney transplantation (PAK) patients have been reported as being inferior to those of patients who receive simultaneous pancreas and kidney transplantation (SPK). The influence of the kidney donor (i.e. living versus deceased) has never been previously addressed....

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Autores: Abreu Aguiarà, Pedro Ventura, Ferrer Fábrega, Joana, Revuelta Vicente, Ignacio, Paredes, D. (David), Sousa Amorim, Erika de, Rovira Juárez, Jordi, Esmatjes Mompo, Enrique, García-Valdecasas Salgado, Juan Carlos, Campistol Plana, Josep M., Oppenheimer Salinas, Federico, Diekmann, Fritz, Ricart Brulles, Ma. José
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/224374
Acceso en línea:https://hdl.handle.net/2445/224374
Access Level:acceso abierto
Palabra clave:Trasplantament renal
Pàncrees
Donants d'òrgans
Kidney transplantation
Pancreas
Organ donors
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spelling Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.Abreu Aguiarà, Pedro VenturaFerrer Fábrega, JoanaRevuelta Vicente, IgnacioParedes, D. (David)Sousa Amorim, Erika deRovira Juárez, JordiEsmatjes Mompo, EnriqueGarcía-Valdecasas Salgado, Juan CarlosCampistol Plana, Josep M.Oppenheimer Salinas, FedericoDiekmann, FritzRicart Brulles, Ma. JoséTrasplantament renalPàncreesDonants d'òrgansKidney transplantationPancreasOrgan donorsPancreas outcomes in pancreas after kidney transplantation (PAK) patients have been reported as being inferior to those of patients who receive simultaneous pancreas and kidney transplantation (SPK). The influence of the kidney donor (i.e. living versus deceased) has never been previously addressed.We retrospectively analysed all pancreas transplants performed in a single centre since 2007 and compared the outcomes between those patients who had previously received a living-donor kidney transplant (pancreas transplantation after living-donor kidney transplantation, PAldK; n?=?18) or a deceased-donor kidney transplant (pancreas transplantation after deceased-donor kidney transplantation, PAddK; n?=?28), using SPK (n?=?139) recipients as a reference.Pancreas survival was similar between all groups, but inferior for PAldK when including only those with a functioning graft at day 90 post-transplantation (P?=?0.004). Pancreas acute rejection was significantly increased in PAldK (67%; 1.8?±?1.4 episodes/graft) when compared with PAddK (25%) and SPK (32%) (P?<?0.05) patients. In a multivariate Cox regression model including known risk factors for pancreas rejection, PAldK was the only predictor of acute rejection (hazard ratio 6.82, 95% confidence interval 1.51-30.70, P?<?0.05). No association was found between donor-recipient HLA mismatches and graft rejection. Repeated HLA mismatches between kidney and pancreas donors (0 versus 1-6) did not correlate with pancreas graft rejection or survival in either PAK transplantation group (P?>?0.05).Pancreas graft outcomes are worse for PAldK when compared with PAddK and SPK patients.Oxford University Press2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/224374Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaVersió postprint del document publicat a: https://doi.org/10.1093/ndt/gfy133Nephrology Dialysis Transplantation, 2018, vol. 33, num. 11, p. 2052-2059https://doi.org/10.1093/ndt/gfy133(c) Oxford University Press, 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2243742026-05-27T06:46:51Z
dc.title.none.fl_str_mv Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.
title Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.
spellingShingle Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.
Abreu Aguiarà, Pedro Ventura
Trasplantament renal
Pàncrees
Donants d'òrgans
Kidney transplantation
Pancreas
Organ donors
title_short Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.
title_full Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.
title_fullStr Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.
title_full_unstemmed Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.
title_sort Pancreas outcomes between living and deceased kidney donor in pancreas after kidney transplantation patients.
dc.creator.none.fl_str_mv Abreu Aguiarà, Pedro Ventura
Ferrer Fábrega, Joana
Revuelta Vicente, Ignacio
Paredes, D. (David)
Sousa Amorim, Erika de
Rovira Juárez, Jordi
Esmatjes Mompo, Enrique
García-Valdecasas Salgado, Juan Carlos
Campistol Plana, Josep M.
Oppenheimer Salinas, Federico
Diekmann, Fritz
Ricart Brulles, Ma. José
author Abreu Aguiarà, Pedro Ventura
author_facet Abreu Aguiarà, Pedro Ventura
Ferrer Fábrega, Joana
Revuelta Vicente, Ignacio
Paredes, D. (David)
Sousa Amorim, Erika de
Rovira Juárez, Jordi
Esmatjes Mompo, Enrique
García-Valdecasas Salgado, Juan Carlos
Campistol Plana, Josep M.
Oppenheimer Salinas, Federico
Diekmann, Fritz
Ricart Brulles, Ma. José
author_role author
author2 Ferrer Fábrega, Joana
Revuelta Vicente, Ignacio
Paredes, D. (David)
Sousa Amorim, Erika de
Rovira Juárez, Jordi
Esmatjes Mompo, Enrique
García-Valdecasas Salgado, Juan Carlos
Campistol Plana, Josep M.
Oppenheimer Salinas, Federico
Diekmann, Fritz
Ricart Brulles, Ma. José
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trasplantament renal
Pàncrees
Donants d'òrgans
Kidney transplantation
Pancreas
Organ donors
topic Trasplantament renal
Pàncrees
Donants d'òrgans
Kidney transplantation
Pancreas
Organ donors
description Pancreas outcomes in pancreas after kidney transplantation (PAK) patients have been reported as being inferior to those of patients who receive simultaneous pancreas and kidney transplantation (SPK). The influence of the kidney donor (i.e. living versus deceased) has never been previously addressed.We retrospectively analysed all pancreas transplants performed in a single centre since 2007 and compared the outcomes between those patients who had previously received a living-donor kidney transplant (pancreas transplantation after living-donor kidney transplantation, PAldK; n?=?18) or a deceased-donor kidney transplant (pancreas transplantation after deceased-donor kidney transplantation, PAddK; n?=?28), using SPK (n?=?139) recipients as a reference.Pancreas survival was similar between all groups, but inferior for PAldK when including only those with a functioning graft at day 90 post-transplantation (P?=?0.004). Pancreas acute rejection was significantly increased in PAldK (67%; 1.8?±?1.4 episodes/graft) when compared with PAddK (25%) and SPK (32%) (P?<?0.05) patients. In a multivariate Cox regression model including known risk factors for pancreas rejection, PAldK was the only predictor of acute rejection (hazard ratio 6.82, 95% confidence interval 1.51-30.70, P?<?0.05). No association was found between donor-recipient HLA mismatches and graft rejection. Repeated HLA mismatches between kidney and pancreas donors (0 versus 1-6) did not correlate with pancreas graft rejection or survival in either PAK transplantation group (P?>?0.05).Pancreas graft outcomes are worse for PAldK when compared with PAddK and SPK patients.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/224374
url https://hdl.handle.net/2445/224374
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1093/ndt/gfy133
Nephrology Dialysis Transplantation, 2018, vol. 33, num. 11, p. 2052-2059
https://doi.org/10.1093/ndt/gfy133
dc.rights.none.fl_str_mv (c) Oxford University Press, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Oxford University Press, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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