Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance

Background Increased iron stores are associated with increased risk of type 2 diabetes, however, the mechanisms underlying these associations are poorly understood. Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is r...

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Autores: Juanola-Falgarona, Martí, Cándido-Fernández, José, Salas Salvadó, Jordi, Martínez-González, Miguel Ángel, 1957-, Estruch Riba, Ramon, Fiol Sala, Miguel, Arija Val, Victoria, Bulló, Mònica
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/124863
Acceso en línea:https://hdl.handle.net/2445/124863
Access Level:acceso abierto
Palabra clave:Resistència a la insulina
Ferro en l'organisme
Diabetis
Insulin resistance
Iron in the body
Diabetes
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spelling Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistanceJuanola-Falgarona, MartíCándido-Fernández, JoséSalas Salvadó, JordiMartínez-González, Miguel Ángel, 1957-Estruch Riba, RamonFiol Sala, MiguelArija Val, VictoriaBulló, MònicaResistència a la insulinaFerro en l'organismeDiabetisInsulin resistanceIron in the bodyDiabetesBackground Increased iron stores are associated with increased risk of type 2 diabetes, however, the mechanisms underlying these associations are poorly understood. Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus. Objective To analyzed the associations between serum total and uncarboxylated osteocalcin and adiponectin concentrations with serum ferritin and soluble transferrin receptor (sTfR) in elderly subjects. Design We evaluated a total of 423 subjects from the PREDIMED cohort in a population-based cross-sectional analysis. Extensive clinical, nutritional and laboratory measurements, including total and uncarboxylated osteocalcin, adiponectin, ferritin and sTfR were recorded. Results Serum ferritin was positively correlated with increased glucose and insulin circulating levels but also with HOMA-IR, and was inversely associated with total osteocalcin and adiponectin. A regression analysis revealed that serum ferritin and transferrin receptor levels were significantly associated with a decrease in total and uncarboxylated osteocalcin. Serum sTfR levels were associated with lower uncarboxylated osteocalcin levels in the whole-study subjects and remained significant only in the IFG (impaired fasting glucose) individuals. Conclusions We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus.Public Library of Science (PLoS)2018201820132018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/124863Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0076433PLoS One, 2013, vol. 8, num. 10, p. e76433https://doi.org/10.1371/journal.pone.0076433cc-by (c) Juanola-Falgarona, Martí et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1248632026-05-29T05:05:01Z
dc.title.none.fl_str_mv Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance
title Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance
spellingShingle Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance
Juanola-Falgarona, Martí
Resistència a la insulina
Ferro en l'organisme
Diabetis
Insulin resistance
Iron in the body
Diabetes
title_short Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance
title_full Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance
title_fullStr Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance
title_full_unstemmed Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance
title_sort Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance
dc.creator.none.fl_str_mv Juanola-Falgarona, Martí
Cándido-Fernández, José
Salas Salvadó, Jordi
Martínez-González, Miguel Ángel, 1957-
Estruch Riba, Ramon
Fiol Sala, Miguel
Arija Val, Victoria
Bulló, Mònica
author Juanola-Falgarona, Martí
author_facet Juanola-Falgarona, Martí
Cándido-Fernández, José
Salas Salvadó, Jordi
Martínez-González, Miguel Ángel, 1957-
Estruch Riba, Ramon
Fiol Sala, Miguel
Arija Val, Victoria
Bulló, Mònica
author_role author
author2 Cándido-Fernández, José
Salas Salvadó, Jordi
Martínez-González, Miguel Ángel, 1957-
Estruch Riba, Ramon
Fiol Sala, Miguel
Arija Val, Victoria
Bulló, Mònica
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Resistència a la insulina
Ferro en l'organisme
Diabetis
Insulin resistance
Iron in the body
Diabetes
topic Resistència a la insulina
Ferro en l'organisme
Diabetis
Insulin resistance
Iron in the body
Diabetes
description Background Increased iron stores are associated with increased risk of type 2 diabetes, however, the mechanisms underlying these associations are poorly understood. Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus. Objective To analyzed the associations between serum total and uncarboxylated osteocalcin and adiponectin concentrations with serum ferritin and soluble transferrin receptor (sTfR) in elderly subjects. Design We evaluated a total of 423 subjects from the PREDIMED cohort in a population-based cross-sectional analysis. Extensive clinical, nutritional and laboratory measurements, including total and uncarboxylated osteocalcin, adiponectin, ferritin and sTfR were recorded. Results Serum ferritin was positively correlated with increased glucose and insulin circulating levels but also with HOMA-IR, and was inversely associated with total osteocalcin and adiponectin. A regression analysis revealed that serum ferritin and transferrin receptor levels were significantly associated with a decrease in total and uncarboxylated osteocalcin. Serum sTfR levels were associated with lower uncarboxylated osteocalcin levels in the whole-study subjects and remained significant only in the IFG (impaired fasting glucose) individuals. Conclusions We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus.
publishDate 2013
dc.date.none.fl_str_mv 2013
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124863
url https://hdl.handle.net/2445/124863
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0076433
PLoS One, 2013, vol. 8, num. 10, p. e76433
https://doi.org/10.1371/journal.pone.0076433
dc.rights.none.fl_str_mv cc-by (c) Juanola-Falgarona, Martí et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Juanola-Falgarona, Martí et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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