Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic

Background: Coagulopathies detected in horses with gastrointestinal problems seem to be associated with poor outcome. Plasma D-Dimer concentration is a sensitive test for assessing coagulopathies. Hypothesis: Plasma D-Dimer concentration tested on admission is related to diagnosis and outcome in hor...

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Autores: Armengou Ruiz, Lara|||0000-0003-4715-7323, José Cunilleras, Eduard|||0000-0002-4536-7717, Cesarini Latorre, Carlota, Monreal Bosch, Luis, Ríos, José|||0000-0002-0716-8784, Delgado Jorde, M. Àngels
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:215813
Acceso en línea:https://ddd.uab.cat/record/215813
https://dx.doi.org/urn:doi:10.1111/j.1939-1676.2010.0618.x
Access Level:acceso abierto
Palabra clave:Còlic en els cavalls
Aparell digestiu
Malalties
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spelling Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colicArmengou Ruiz, Lara|||0000-0003-4715-7323José Cunilleras, Eduard|||0000-0002-4536-7717Cesarini Latorre, CarlotaMonreal Bosch, LuisRíos, José|||0000-0002-0716-8784Delgado Jorde, M. ÀngelsCòlic en els cavallsAparell digestiuMalaltiesBackground: Coagulopathies detected in horses with gastrointestinal problems seem to be associated with poor outcome. Plasma D-Dimer concentration is a sensitive test for assessing coagulopathies. Hypothesis: Plasma D-Dimer concentration tested on admission is related to diagnosis and outcome in horses with colic. Animals: Four hundred and ninety three horses referred for evaluation of abdominal pain. Methods: Prospective observational clinical study. Horses were grouped according to diagnosis (medical and surgical intestinal obstructions, ischemic disorders with and without intestinal resection, enteritis, peritonitis), outcome (survivors, nonsurvivors), and number of coagulopathies (normal profile, 1 or 2 coagulopathies, subclinical disseminated intravascular coagulation [DIC]). Blood samples were collected on admission and plasma D-Dimer concentration, clotting times (PT and aPTT), and antithrombin activity were determined. Positive likelihood ratios (LR1) were calculated for evaluation of D-Dimer cut-off values, which were later tested in a logistic regression model. Results: Horses with enteritis or peritonitis had significantly (P o .001) higher plasma D-Dimer concentrations and more severe coagulopathies on admission than horses with other diagnoses. Nonsurvivors also had significantly (P o .001) higher plasma D-Dimer concentrations at presentation than did survivors, and those horses with subclinical DIC on presentation had an odds ratio (OR) 8.6 (95% confidence interval [CI], 3.3-22.5, P o .001) for nonsurvival. Finally, D-Dimer concentrations 44,000 ng/mL had a LR1 of 5.9 and an OR 8.8 (95% CI, 4.5-17.1, Po .001) for nonsurvival. Conclusion and Clinical Importance: Plasma D-Dimer concentration measured on admission can be used to facilitate diagnosis and outcome prediction in horses with colic. A potential cut-off value for nonsurvival was found at approximately 4,000 ng/mL 22010-01-0120102010-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/215813https://dx.doi.org/urn:doi:10.1111/j.1939-1676.2010.0618.xreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2158132026-06-06T12:50:31Z
dc.title.none.fl_str_mv Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic
title Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic
spellingShingle Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic
Armengou Ruiz, Lara|||0000-0003-4715-7323
Còlic en els cavalls
Aparell digestiu
Malalties
title_short Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic
title_full Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic
title_fullStr Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic
title_full_unstemmed Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic
title_sort Association of admission plasma D-Dimer concentration with diagnosis and outcome in horses with colic
dc.creator.none.fl_str_mv Armengou Ruiz, Lara|||0000-0003-4715-7323
José Cunilleras, Eduard|||0000-0002-4536-7717
Cesarini Latorre, Carlota
Monreal Bosch, Luis
Ríos, José|||0000-0002-0716-8784
Delgado Jorde, M. Àngels
author Armengou Ruiz, Lara|||0000-0003-4715-7323
author_facet Armengou Ruiz, Lara|||0000-0003-4715-7323
José Cunilleras, Eduard|||0000-0002-4536-7717
Cesarini Latorre, Carlota
Monreal Bosch, Luis
Ríos, José|||0000-0002-0716-8784
Delgado Jorde, M. Àngels
author_role author
author2 José Cunilleras, Eduard|||0000-0002-4536-7717
Cesarini Latorre, Carlota
Monreal Bosch, Luis
Ríos, José|||0000-0002-0716-8784
Delgado Jorde, M. Àngels
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Còlic en els cavalls
Aparell digestiu
Malalties
topic Còlic en els cavalls
Aparell digestiu
Malalties
description Background: Coagulopathies detected in horses with gastrointestinal problems seem to be associated with poor outcome. Plasma D-Dimer concentration is a sensitive test for assessing coagulopathies. Hypothesis: Plasma D-Dimer concentration tested on admission is related to diagnosis and outcome in horses with colic. Animals: Four hundred and ninety three horses referred for evaluation of abdominal pain. Methods: Prospective observational clinical study. Horses were grouped according to diagnosis (medical and surgical intestinal obstructions, ischemic disorders with and without intestinal resection, enteritis, peritonitis), outcome (survivors, nonsurvivors), and number of coagulopathies (normal profile, 1 or 2 coagulopathies, subclinical disseminated intravascular coagulation [DIC]). Blood samples were collected on admission and plasma D-Dimer concentration, clotting times (PT and aPTT), and antithrombin activity were determined. Positive likelihood ratios (LR1) were calculated for evaluation of D-Dimer cut-off values, which were later tested in a logistic regression model. Results: Horses with enteritis or peritonitis had significantly (P o .001) higher plasma D-Dimer concentrations and more severe coagulopathies on admission than horses with other diagnoses. Nonsurvivors also had significantly (P o .001) higher plasma D-Dimer concentrations at presentation than did survivors, and those horses with subclinical DIC on presentation had an odds ratio (OR) 8.6 (95% confidence interval [CI], 3.3-22.5, P o .001) for nonsurvival. Finally, D-Dimer concentrations 44,000 ng/mL had a LR1 of 5.9 and an OR 8.8 (95% CI, 4.5-17.1, Po .001) for nonsurvival. Conclusion and Clinical Importance: Plasma D-Dimer concentration measured on admission can be used to facilitate diagnosis and outcome prediction in horses with colic. A potential cut-off value for nonsurvival was found at approximately 4,000 ng/mL
publishDate 2010
dc.date.none.fl_str_mv 2
2010-01-01
2010
2010-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/215813
https://dx.doi.org/urn:doi:10.1111/j.1939-1676.2010.0618.x
url https://ddd.uab.cat/record/215813
https://dx.doi.org/urn:doi:10.1111/j.1939-1676.2010.0618.x
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
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