The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials

Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to establish rational dosage regimens of antimicrobial agents in human and veterinary medicine. Actually, PK/PD studies are included in the European Medicines Agency (EMA) guidelines for the evaluation of medicinal product...

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Autores: Rodríguez Gascón, Alicia, Solinís Aspiazu, María Ángeles, Isla Ruiz, Arantxazu
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/52262
Acceso en línea:http://hdl.handle.net/10810/52262
Access Level:acceso abierto
Palabra clave:antibiotic
pharmacokinetics
pharmacodynamics
antimicrobial resistance
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spelling The Role of PK/PD Analysis in the Development and Evaluation of AntimicrobialsRodríguez Gascón, AliciaSolinís Aspiazu, María ÁngelesIsla Ruiz, Arantxazuantibioticpharmacokineticspharmacodynamicsantimicrobial resistancePharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to establish rational dosage regimens of antimicrobial agents in human and veterinary medicine. Actually, PK/PD studies are included in the European Medicines Agency (EMA) guidelines for the evaluation of medicinal products. The PK/PD approach implies the use of in vitro, ex vivo, and in vivo models, as well as mathematical models to describe the relationship between the kinetics and the dynamic to determine the optimal dosing regimens of antimicrobials, but also to establish susceptibility breakpoints, and prevention of resistance. The final goal is to optimize therapy in order to maximize efficacy and minimize side effects and emergence of resistance. In this review, we revise the PK/PD principles and the models to investigate the relationship between the PK and the PD of antibiotics. Additionally, we highlight the outstanding role of the PK/PD analysis at different levels, from the development and evaluation of new antibiotics to the optimization of the dosage regimens of currently available drugs, both for human and animal use.This research was funded by the Department of Education of the Basque Government (PIBA 2019-57) and by the University of the Basque Country UPV/EHU (GIU 17/32).MDPI2021202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/52262reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.mdpi.com/1999-4923/13/6/833info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/522622026-06-18T09:23:17Z
dc.title.none.fl_str_mv The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
title The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
spellingShingle The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
Rodríguez Gascón, Alicia
antibiotic
pharmacokinetics
pharmacodynamics
antimicrobial resistance
title_short The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
title_full The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
title_fullStr The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
title_full_unstemmed The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
title_sort The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
dc.creator.none.fl_str_mv Rodríguez Gascón, Alicia
Solinís Aspiazu, María Ángeles
Isla Ruiz, Arantxazu
author Rodríguez Gascón, Alicia
author_facet Rodríguez Gascón, Alicia
Solinís Aspiazu, María Ángeles
Isla Ruiz, Arantxazu
author_role author
author2 Solinís Aspiazu, María Ángeles
Isla Ruiz, Arantxazu
author2_role author
author
dc.subject.none.fl_str_mv antibiotic
pharmacokinetics
pharmacodynamics
antimicrobial resistance
topic antibiotic
pharmacokinetics
pharmacodynamics
antimicrobial resistance
description Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to establish rational dosage regimens of antimicrobial agents in human and veterinary medicine. Actually, PK/PD studies are included in the European Medicines Agency (EMA) guidelines for the evaluation of medicinal products. The PK/PD approach implies the use of in vitro, ex vivo, and in vivo models, as well as mathematical models to describe the relationship between the kinetics and the dynamic to determine the optimal dosing regimens of antimicrobials, but also to establish susceptibility breakpoints, and prevention of resistance. The final goal is to optimize therapy in order to maximize efficacy and minimize side effects and emergence of resistance. In this review, we revise the PK/PD principles and the models to investigate the relationship between the PK and the PD of antibiotics. Additionally, we highlight the outstanding role of the PK/PD analysis at different levels, from the development and evaluation of new antibiotics to the optimization of the dosage regimens of currently available drugs, both for human and animal use.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/52262
url http://hdl.handle.net/10810/52262
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/1999-4923/13/6/833
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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