Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment

High-throughput sequencing studies have shown that diet or antimicrobial treatments impact animal gut microbiota equilibrium. However, properties related to the gut microbial ecosystem stability, such as resilience, resistance, or functional redundancy, must be better understood. To shed light on th...

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Autores: Marín-Miret J, Pérez-Cobas AE, Domínguez-Santos R, Pérez-Rocher B, Latorre A, Moya A
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2024
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositório:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p17600
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/17600
Access Level:Acceso aberto
Palavra-chave:Gut microbiota
Cockroach
Antibiotic treatment
Resilience
Resistance
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spelling Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatmentMarín-Miret JPérez-Cobas AEDomínguez-Santos RPérez-Rocher BLatorre AMoya AGut microbiotaCockroachAntibiotic treatmentResilienceResistanceHigh-throughput sequencing studies have shown that diet or antimicrobial treatments impact animal gut microbiota equilibrium. However, properties related to the gut microbial ecosystem stability, such as resilience, resistance, or functional redundancy, must be better understood. To shed light on these ecological processes, we combined advanced statistical methods with 16 S rRNA gene sequencing, functional prediction, and fitness analyses in the gut microbiota of the cockroach Blattella germanica subject to three periodic pulses of the antibiotic (AB) kanamycin (n=512). =512). We first confirmed that AB did not significantly affect cockroaches' biological fitness, and gut microbiota changes were not caused by insect physiology alterations. The sex variable was examined for the first time in this species, and no statistical differences in the gut microbiota diversity or composition were found. The comparison of the gut microbiota dynamics in control and treated populations revealed that (1) AB treatment decreases diversity and completely disrupts the co-occurrence networks between bacteria, significantly altering the gut community structure. (2) Although AB also affected the genetic composition, functional redundancy would explain a smaller effect on the functional potential than on the taxonomic composition. (3) As predicted by Taylor's law, AB generally affected the most abundant taxa to a lesser extent than the less abundant taxa. (4) Taxa follow different trends in response to ABs, highlighting "resistant taxa," which could be critical for community restoration. (5) The gut microbiota recovered faster after the three AB pulses, suggesting that gut microbiota adapts to repeated treatments.ELSEVIER GMBH2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/17600MICROBIOLOGICAL RESEARCHISSN: 09445013ISSNe: 16180623reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p176002026-06-11T12:45:17Z
dc.title.none.fl_str_mv Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment
title Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment
spellingShingle Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment
Marín-Miret J
Gut microbiota
Cockroach
Antibiotic treatment
Resilience
Resistance
title_short Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment
title_full Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment
title_fullStr Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment
title_full_unstemmed Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment
title_sort Adaptability of the gut microbiota of the German cockroach Blattella germanica to a periodic antibiotic treatment
dc.creator.none.fl_str_mv Marín-Miret J
Pérez-Cobas AE
Domínguez-Santos R
Pérez-Rocher B
Latorre A
Moya A
author Marín-Miret J
author_facet Marín-Miret J
Pérez-Cobas AE
Domínguez-Santos R
Pérez-Rocher B
Latorre A
Moya A
author_role author
author2 Pérez-Cobas AE
Domínguez-Santos R
Pérez-Rocher B
Latorre A
Moya A
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Gut microbiota
Cockroach
Antibiotic treatment
Resilience
Resistance
topic Gut microbiota
Cockroach
Antibiotic treatment
Resilience
Resistance
description High-throughput sequencing studies have shown that diet or antimicrobial treatments impact animal gut microbiota equilibrium. However, properties related to the gut microbial ecosystem stability, such as resilience, resistance, or functional redundancy, must be better understood. To shed light on these ecological processes, we combined advanced statistical methods with 16 S rRNA gene sequencing, functional prediction, and fitness analyses in the gut microbiota of the cockroach Blattella germanica subject to three periodic pulses of the antibiotic (AB) kanamycin (n=512). =512). We first confirmed that AB did not significantly affect cockroaches' biological fitness, and gut microbiota changes were not caused by insect physiology alterations. The sex variable was examined for the first time in this species, and no statistical differences in the gut microbiota diversity or composition were found. The comparison of the gut microbiota dynamics in control and treated populations revealed that (1) AB treatment decreases diversity and completely disrupts the co-occurrence networks between bacteria, significantly altering the gut community structure. (2) Although AB also affected the genetic composition, functional redundancy would explain a smaller effect on the functional potential than on the taxonomic composition. (3) As predicted by Taylor's law, AB generally affected the most abundant taxa to a lesser extent than the less abundant taxa. (4) Taxa follow different trends in response to ABs, highlighting "resistant taxa," which could be critical for community restoration. (5) The gut microbiota recovered faster after the three AB pulses, suggesting that gut microbiota adapts to repeated treatments.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/17600
url https://fisabio.portalinvestigacion.com/publicaciones/17600
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER GMBH
publisher.none.fl_str_mv ELSEVIER GMBH
dc.source.none.fl_str_mv MICROBIOLOGICAL RESEARCH
ISSN: 09445013
ISSNe: 16180623
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
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repository.mail.fl_str_mv
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