The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation

Includes supplementary materials for the online appendix.

Detalhes bibliográficos
Autores: Rolls, Edmund T., Wirth, Sylvia, Deco, Gustavo, Huang, Chu-Chung, Feng, Jianfeng
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/56177
Acesso em linha:http://hdl.handle.net/10230/56177
http://dx.doi.org/10.1002/hbm.26089
Access Level:acceso abierto
Palavra-chave:Hippocampus
Memory
Midcingulate cortex
Navigation
Posterior cingulate cortex
Retrosplenial cortex
Spatial view cells
Visuo-motor coordinate transforms
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dc.title.none.fl_str_mv The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
title The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
spellingShingle The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
Rolls, Edmund T.
Hippocampus
Memory
Midcingulate cortex
Navigation
Posterior cingulate cortex
Retrosplenial cortex
Spatial view cells
Visuo-motor coordinate transforms
title_short The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
title_full The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
title_fullStr The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
title_full_unstemmed The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
title_sort The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation
dc.creator.none.fl_str_mv Rolls, Edmund T.
Wirth, Sylvia
Deco, Gustavo
Huang, Chu-Chung
Feng, Jianfeng
author Rolls, Edmund T.
author_facet Rolls, Edmund T.
Wirth, Sylvia
Deco, Gustavo
Huang, Chu-Chung
Feng, Jianfeng
author_role author
author2 Wirth, Sylvia
Deco, Gustavo
Huang, Chu-Chung
Feng, Jianfeng
author2_role author
author
author
author
dc.subject.none.fl_str_mv Hippocampus
Memory
Midcingulate cortex
Navigation
Posterior cingulate cortex
Retrosplenial cortex
Spatial view cells
Visuo-motor coordinate transforms
topic Hippocampus
Memory
Midcingulate cortex
Navigation
Posterior cingulate cortex
Retrosplenial cortex
Spatial view cells
Visuo-motor coordinate transforms
description Includes supplementary materials for the online appendix.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/56177
http://dx.doi.org/10.1002/hbm.26089
url http://hdl.handle.net/10230/56177
http://dx.doi.org/10.1002/hbm.26089
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Human Brain Mapping. 2023 Feb 1;44(2):629-55
info:eu-repo/grantAgreement/EC/H2020/945539
info:eu-repo/grantAgreement/EC/H2020/101017716
info:eu-repo/grantAgreement/EC/H2020/860563
info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigationRolls, Edmund T.Wirth, SylviaDeco, GustavoHuang, Chu-ChungFeng, JianfengHippocampusMemoryMidcingulate cortexNavigationPosterior cingulate cortexRetrosplenial cortexSpatial view cellsVisuo-motor coordinate transformsIncludes supplementary materials for the online appendix.The human posterior cingulate, retrosplenial, and medial parietal cortex are involved in memory and navigation. The functional anatomy underlying these cognitive functions was investigated by measuring the effective connectivity of these Posterior Cingulate Division (PCD) regions in the Human Connectome Project-MMP1 atlas in 171 HCP participants, and complemented with functional connectivity and diffusion tractography. First, the postero-ventral parts of the PCD (31pd, 31pv, 7m, d23ab, and v23ab) have effective connectivity with the temporal pole, inferior temporal visual cortex, cortex in the superior temporal sulcus implicated in auditory and semantic processing, with the reward-related vmPFC and pregenual anterior cingulate cortex, with the inferior parietal cortex, and with the hippocampal system. This connectivity implicates it in hippocampal episodic memory, providing routes for “what,” reward and semantic schema-related information to access the hippocampus. Second, the antero-dorsal parts of the PCD (especially 31a and 23d, PCV, and also RSC) have connectivity with early visual cortical areas including those that represent spatial scenes, with the superior parietal cortex, with the pregenual anterior cingulate cortex, and with the hippocampal system. This connectivity implicates it in the “where” component for hippocampal episodic memory and for spatial navigation. The dorsal–transitional–visual (DVT) and ProStriate regions where the retrosplenial scene area is located have connectivity from early visual cortical areas to the parahippocampal scene area, providing a ventromedial route for spatial scene information to reach the hippocampus. These connectivities provide important routes for “what,” reward, and “where” scene-related information for human hippocampal episodic memory and navigation. The midcingulate cortex provides a route from the anterior dorsal parts of the PCD and the supracallosal part of the anterior cingulate cortex to premotor regions.The research was supported by the following grants to Professor J. Feng: National Key R&D Program of China (No. 2019YFA0709502); 111 Project (No. B18015); Shanghai Municipal Science and Technology Major Project, ZJLab, and Shanghai Center for Brain Science and Brain-Inspired Technology (No. 2018SHZDZX01); and National Key R&D Program of China (No. 2018YFC1312904). G.D. is supported by a Spanish National Research Project funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) (ref. PID2019-105772GB-I00 MCIU AEI); HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship programme; SGR Research Support Group Support (ref. 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR); Neurotwin Digital twins for model-driven non-invasive electrical brain stimulation (grant agreement ID: 101017716) funded by the EU H2020 FET Proactive Programme; euSNN European School of Network Neuroscience (grant agreement ID: 860563) funded by the EU H2020 MSCA-ITN Innovative Training Networks; CECH The Emerging Human Brain Cluster (Id. 001-P-001682) within the framework of the European Research Development Fund Operational Program of Catalonia 2014–2020; Brain-Connects: Brain Connectivity during Stroke Recovery and Rehabilitation (id. 201725.33) funded by the Fundacio La Marato TV3; Corticity, FLAG ERA JTC 2017, (ref. PCI2018-092891) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). The funding agencies played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.Wiley202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/56177http://dx.doi.org/10.1002/hbm.26089reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésHuman Brain Mapping. 2023 Feb 1;44(2):629-55info:eu-repo/grantAgreement/EC/H2020/945539info:eu-repo/grantAgreement/EC/H2020/101017716info:eu-repo/grantAgreement/EC/H2020/860563info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of theCreative Commons AttributionLicense, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/561772026-06-12T07:21:37Z
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