The interaction of maternal diabetes with mutations that affect folate metabolism and how they affect the development of neural tube defects in mice
Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTDs) in humans and animal models. Nevertheless, how these two factors might interact in the development of NTDs remains unclear.
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/347935 |
| Acceso en línea: | http://hdl.handle.net/10261/347935 https://api.elsevier.com/content/abstract/scopus_id/85071311546 |
| Access Level: | acceso abierto |
| Palabra clave: | Hyperglycemia Folr1 Mthfr NTDs Folic acid Homocysteine |
| Sumario: | Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTDs) in humans and animal models. Nevertheless, how these two factors might interact in the development of NTDs remains unclear. |
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