The complement system in ovarian cancer: an underexplored old path

Ovarian cancer is one of the most lethal gynecological cancers. Current therapeutic strategies allow temporary control of the disease, but most patients develop resistance to treatment. Moreover, although successful in a range of solid tumors, immunotherapy has yielded only modest results in ovarian...

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Autores: Senent, Y. (Yaiza)|||/items/0a72caef-9e28-4ad3-aa19-523d5f4d4536, Ajona, D. (Daniel)|||/items/33f1d5ec-5a97-4d7f-a428-499e5075fc78, González-Martín, A. (Antonio)|||/items/47e72e63-32d3-4a8a-91d5-2624d704fb4e, Pio, R. (Rubén)|||/items/d5c409b3-dbed-4f0c-8bad-94c31e0e5a95, Tavira-Iglesias, B. (Beatriz)|||/items/6ce7d37d-a428-40d9-a4be-600697a7a56f
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/114687
Acesso em linha:https://hdl.handle.net/10171/114687
Access Level:acceso abierto
Palavra-chave:Adaptive immunity
Cancer immunology
Complement system
Immunotherapy
Innate immunity
Ovarian cancer
Tumor microenvironment
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spelling The complement system in ovarian cancer: an underexplored old pathSenent, Y. (Yaiza)|||/items/0a72caef-9e28-4ad3-aa19-523d5f4d4536Ajona, D. (Daniel)|||/items/33f1d5ec-5a97-4d7f-a428-499e5075fc78González-Martín, A. (Antonio)|||/items/47e72e63-32d3-4a8a-91d5-2624d704fb4ePio, R. (Rubén)|||/items/d5c409b3-dbed-4f0c-8bad-94c31e0e5a95Tavira-Iglesias, B. (Beatriz)|||/items/6ce7d37d-a428-40d9-a4be-600697a7a56fAdaptive immunityCancer immunologyComplement systemImmunotherapyInnate immunityOvarian cancerTumor microenvironmentOvarian cancer is one of the most lethal gynecological cancers. Current therapeutic strategies allow temporary control of the disease, but most patients develop resistance to treatment. Moreover, although successful in a range of solid tumors, immunotherapy has yielded only modest results in ovarian cancer. Emerging evidence underscores the relevance of the components of innate and adaptive immunity in ovarian cancer progression and response to treatment. Particularly, over the last decade, the complement system, a pillar of innate immunity, has emerged as a major regulator of the tumor microenvironment in cancer immunity. Tumor-associated complement activation may support chronic inflammation, promote an immunosuppressive microenvironment, induce angiogenesis, and activate cancer-related signaling pathways. Recent insights suggest an important role of complement effectors, such as C1q or anaphylatoxins C3a and C5a, and their receptors C3aR and C5aR1 in ovarian cancer progression. Nevertheless, the implication of these factors in different clinical contexts is still poorly understood. Detailed knowledge of the interplay between ovarian cancer cells and complement is required to develop new immunotherapy combinations and biomarkers. In this context, we discuss the possibility of targeting complement to overcome some of the hurdles encountered in the treatment of ovarian cancer.MDPIDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/114687reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1146872026-06-21T12:47:57Z
dc.title.none.fl_str_mv The complement system in ovarian cancer: an underexplored old path
title The complement system in ovarian cancer: an underexplored old path
spellingShingle The complement system in ovarian cancer: an underexplored old path
Senent, Y. (Yaiza)|||/items/0a72caef-9e28-4ad3-aa19-523d5f4d4536
Adaptive immunity
Cancer immunology
Complement system
Immunotherapy
Innate immunity
Ovarian cancer
Tumor microenvironment
title_short The complement system in ovarian cancer: an underexplored old path
title_full The complement system in ovarian cancer: an underexplored old path
title_fullStr The complement system in ovarian cancer: an underexplored old path
title_full_unstemmed The complement system in ovarian cancer: an underexplored old path
title_sort The complement system in ovarian cancer: an underexplored old path
dc.creator.none.fl_str_mv Senent, Y. (Yaiza)|||/items/0a72caef-9e28-4ad3-aa19-523d5f4d4536
Ajona, D. (Daniel)|||/items/33f1d5ec-5a97-4d7f-a428-499e5075fc78
González-Martín, A. (Antonio)|||/items/47e72e63-32d3-4a8a-91d5-2624d704fb4e
Pio, R. (Rubén)|||/items/d5c409b3-dbed-4f0c-8bad-94c31e0e5a95
Tavira-Iglesias, B. (Beatriz)|||/items/6ce7d37d-a428-40d9-a4be-600697a7a56f
author Senent, Y. (Yaiza)|||/items/0a72caef-9e28-4ad3-aa19-523d5f4d4536
author_facet Senent, Y. (Yaiza)|||/items/0a72caef-9e28-4ad3-aa19-523d5f4d4536
Ajona, D. (Daniel)|||/items/33f1d5ec-5a97-4d7f-a428-499e5075fc78
González-Martín, A. (Antonio)|||/items/47e72e63-32d3-4a8a-91d5-2624d704fb4e
Pio, R. (Rubén)|||/items/d5c409b3-dbed-4f0c-8bad-94c31e0e5a95
Tavira-Iglesias, B. (Beatriz)|||/items/6ce7d37d-a428-40d9-a4be-600697a7a56f
author_role author
author2 Ajona, D. (Daniel)|||/items/33f1d5ec-5a97-4d7f-a428-499e5075fc78
González-Martín, A. (Antonio)|||/items/47e72e63-32d3-4a8a-91d5-2624d704fb4e
Pio, R. (Rubén)|||/items/d5c409b3-dbed-4f0c-8bad-94c31e0e5a95
Tavira-Iglesias, B. (Beatriz)|||/items/6ce7d37d-a428-40d9-a4be-600697a7a56f
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Adaptive immunity
Cancer immunology
Complement system
Immunotherapy
Innate immunity
Ovarian cancer
Tumor microenvironment
topic Adaptive immunity
Cancer immunology
Complement system
Immunotherapy
Innate immunity
Ovarian cancer
Tumor microenvironment
description Ovarian cancer is one of the most lethal gynecological cancers. Current therapeutic strategies allow temporary control of the disease, but most patients develop resistance to treatment. Moreover, although successful in a range of solid tumors, immunotherapy has yielded only modest results in ovarian cancer. Emerging evidence underscores the relevance of the components of innate and adaptive immunity in ovarian cancer progression and response to treatment. Particularly, over the last decade, the complement system, a pillar of innate immunity, has emerged as a major regulator of the tumor microenvironment in cancer immunity. Tumor-associated complement activation may support chronic inflammation, promote an immunosuppressive microenvironment, induce angiogenesis, and activate cancer-related signaling pathways. Recent insights suggest an important role of complement effectors, such as C1q or anaphylatoxins C3a and C5a, and their receptors C3aR and C5aR1 in ovarian cancer progression. Nevertheless, the implication of these factors in different clinical contexts is still poorly understood. Detailed knowledge of the interplay between ovarian cancer cells and complement is required to develop new immunotherapy combinations and biomarkers. In this context, we discuss the possibility of targeting complement to overcome some of the hurdles encountered in the treatment of ovarian cancer.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/114687
url https://hdl.handle.net/10171/114687
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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