Stress-induced cell depolarization through the MAP kinase-Cdc42 axis

General stress responses, which sense environmental or endogenous signals, aim at promoting cell survival and fitness during adverse conditions. In eukaryotes, mitogen-activated protein (MAP) kinase-driven cascades trigger a shift in the cell's gene expression program as a cellular adaptati...

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Detalles Bibliográficos
Autores: Salat Canela, Clàudia, 1989-, Pérez, Pilar, Ayté del Olmo, José, Hidalgo Hernando, Elena
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/55430
Acceso en línea:http://hdl.handle.net/10230/55430
http://dx.doi.org/10.1016/j.tcb.2022.06.004
Access Level:acceso abierto
Palabra clave:Cdc42
MAP kinase
Inhibition of cell polarity
Oxidative stress response
Phosphorylation of GAPs and GEFs
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spelling Stress-induced cell depolarization through the MAP kinase-Cdc42 axisSalat Canela, Clàudia, 1989-Pérez, PilarAyté del Olmo, JoséHidalgo Hernando, ElenaCdc42MAP kinaseInhibition of cell polarityOxidative stress responsePhosphorylation of GAPs and GEFsGeneral stress responses, which sense environmental or endogenous signals, aim at promoting cell survival and fitness during adverse conditions. In eukaryotes, mitogen-activated protein (MAP) kinase-driven cascades trigger a shift in the cell's gene expression program as a cellular adaptation to stress. Here, we review another aspect of activated MAP kinase cascades reported in fission yeast: the transient inhibition of cell polarity in response to oxidative stress. The phosphorylation by a stress-activated MAP kinase of regulators of the GTPase cell division cycle 42 (Cdc42) causes a transient inhibition of polarized cell growth. The formation of growth sites depends on limiting and essential polarity components. We summarize here some processes in which inhibition of Cdc42 may be a general mechanism to regulate polarized growth also under physiological conditions.This work is supported by grant PGC2018-093920-B-I00 to E.H. and PGC2018-097248-B-I00 to J.A., funded by MCIN/AEI/10.13039/501100011033 and by ‘European Regional Development Fund (ERDF) A way of making Europe’, by the ‘European Union’. The Oxidative Stress and Cell Cycle group is also supported by Generalitat de Catalunya (Spain) (2017-SGR-539) and by Excellence Unit “María de Maeztu” Grant CEX2018-000792-M funded by MCIN/AEI/10.13039/501100011033. E.H. is a recipient of an ICREA Academia Award (Generalitat de Catalunya, Spain). P.P. was supported by grants CSI150P20 and ‘Escalera de Excelencia’ CLU-2017-03 (Junta de Castilla y Leon, Spain; and the European Regional Development Fund, FEDER, EU). C.S-C. was a recipient of a María de Maeztu predoctoral fellowship from the Ministerio de Economía y Competitividad (Spain).Elsevier20232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55430http://dx.doi.org/10.1016/j.tcb.2022.06.004reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésTrends Cell Biol. 2023 Feb;33(2):124-37info:eu-repo/grantAgreement/ES/2PE/PGC2018-093920-B-I00info:eu-repo/grantAgreement/ES/2PE/PGC2018-097248-B-I00© Elsevier http://dx.doi.org/10.1016/j.tcb.2022.06.004info:eu-repo/semantics/openAccessoai:recercat.cat:10230/554302026-05-29T05:05:01Z
dc.title.none.fl_str_mv Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
title Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
spellingShingle Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
Salat Canela, Clàudia, 1989-
Cdc42
MAP kinase
Inhibition of cell polarity
Oxidative stress response
Phosphorylation of GAPs and GEFs
title_short Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
title_full Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
title_fullStr Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
title_full_unstemmed Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
title_sort Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
dc.creator.none.fl_str_mv Salat Canela, Clàudia, 1989-
Pérez, Pilar
Ayté del Olmo, José
Hidalgo Hernando, Elena
author Salat Canela, Clàudia, 1989-
author_facet Salat Canela, Clàudia, 1989-
Pérez, Pilar
Ayté del Olmo, José
Hidalgo Hernando, Elena
author_role author
author2 Pérez, Pilar
Ayté del Olmo, José
Hidalgo Hernando, Elena
author2_role author
author
author
dc.subject.none.fl_str_mv Cdc42
MAP kinase
Inhibition of cell polarity
Oxidative stress response
Phosphorylation of GAPs and GEFs
topic Cdc42
MAP kinase
Inhibition of cell polarity
Oxidative stress response
Phosphorylation of GAPs and GEFs
description General stress responses, which sense environmental or endogenous signals, aim at promoting cell survival and fitness during adverse conditions. In eukaryotes, mitogen-activated protein (MAP) kinase-driven cascades trigger a shift in the cell's gene expression program as a cellular adaptation to stress. Here, we review another aspect of activated MAP kinase cascades reported in fission yeast: the transient inhibition of cell polarity in response to oxidative stress. The phosphorylation by a stress-activated MAP kinase of regulators of the GTPase cell division cycle 42 (Cdc42) causes a transient inhibition of polarized cell growth. The formation of growth sites depends on limiting and essential polarity components. We summarize here some processes in which inhibition of Cdc42 may be a general mechanism to regulate polarized growth also under physiological conditions.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55430
http://dx.doi.org/10.1016/j.tcb.2022.06.004
url http://hdl.handle.net/10230/55430
http://dx.doi.org/10.1016/j.tcb.2022.06.004
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Trends Cell Biol. 2023 Feb;33(2):124-37
info:eu-repo/grantAgreement/ES/2PE/PGC2018-093920-B-I00
info:eu-repo/grantAgreement/ES/2PE/PGC2018-097248-B-I00
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.tcb.2022.06.004
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.tcb.2022.06.004
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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