Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide

Here we report two new artificial pseudopeptidic cages that bind the EYE peptide epitope in pure water at physiological pH (as studied by fluorescence and NMR spectroscopies). The supramolecular complexation of the Tyr residues efficiently precludes their subsequent PTK-catalysed phosphorylation. Ou...

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Detalhes bibliográficos
Autores: Faggi, Enrico, Pérez, Yolanda, Luis, Santiago V., Alfonso, Ignacio
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/178169
Acesso em linha:http://hdl.handle.net/10261/178169
Access Level:Acceso aberto
Palavra-chave:Supramolecular chemistry
Bridged Compounds
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spelling Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptideFaggi, EnricoPérez, YolandaLuis, Santiago V.Alfonso, IgnacioSupramolecular chemistryBridged Compoundscucurbit[7]uril CB[7Here we report two new artificial pseudopeptidic cages that bind the EYE peptide epitope in pure water at physiological pH (as studied by fluorescence and NMR spectroscopies). The supramolecular complexation of the Tyr residues efficiently precludes their subsequent PTK-catalysed phosphorylation. Our results show a supramolecular modulation of the PTK activity by competitive substrate caging. © The Royal Society of Chemistry 2016.Peer reviewedRoyal Society of Chemistry (UK)Alfonso, Ignacio [0000-0003-0678-0362]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/178169reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés10.1039/C6CC03875ASíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1781692026-05-22T06:33:51Z
dc.title.none.fl_str_mv Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
title Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
spellingShingle Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
Faggi, Enrico
Supramolecular chemistry
Bridged Compounds
cucurbit[7]uril CB[7
title_short Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
title_full Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
title_fullStr Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
title_full_unstemmed Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
title_sort Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
dc.creator.none.fl_str_mv Faggi, Enrico
Pérez, Yolanda
Luis, Santiago V.
Alfonso, Ignacio
author Faggi, Enrico
author_facet Faggi, Enrico
Pérez, Yolanda
Luis, Santiago V.
Alfonso, Ignacio
author_role author
author2 Pérez, Yolanda
Luis, Santiago V.
Alfonso, Ignacio
author2_role author
author
author
dc.contributor.none.fl_str_mv Alfonso, Ignacio [0000-0003-0678-0362]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Supramolecular chemistry
Bridged Compounds
cucurbit[7]uril CB[7
topic Supramolecular chemistry
Bridged Compounds
cucurbit[7]uril CB[7
description Here we report two new artificial pseudopeptidic cages that bind the EYE peptide epitope in pure water at physiological pH (as studied by fluorescence and NMR spectroscopies). The supramolecular complexation of the Tyr residues efficiently precludes their subsequent PTK-catalysed phosphorylation. Our results show a supramolecular modulation of the PTK activity by competitive substrate caging. © The Royal Society of Chemistry 2016.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/178169
url http://hdl.handle.net/10261/178169
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.1039/C6CC03875A
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry (UK)
publisher.none.fl_str_mv Royal Society of Chemistry (UK)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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