S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome

Objective. To identify biomarkers of articular and ocular disease activity in patients with Blau syndrome (BS) Methods. Multiplex plasma protein arrays were performed in five BS patients and eight normal healthy volunteers (NHVs). Plasma S100A12 and S100A8/9 were subsequently measured by ELISA at ba...

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Autores: Wang L, Rosé CD, Foley KP, Anton J, Bader-Meunier B, Brissaud P, Chédeville G, Cimaz R, Fernández-Martín J, Guly C, Hachulla E, Harjacek M, Mackensen F, Merino R, Modesto C, Naranjo Hernández A, Pajot C, Ramanan AV, Thatayatikom A, Thomée C, Vastert S, Votta BJ, Bertin J, Wouters CH
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p14191
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14191
Access Level:acceso abierto
Palabra clave:S100 proteins
Blau syndrome
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spelling S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndromeWang LRosé CDFoley KPAnton JBader-Meunier BBrissaud PChédeville GCimaz RFernández-Martín JGuly CHachulla EHarjacek MMackensen FMerino RModesto CNaranjo Hernández APajot CRamanan AVThatayatikom AThomée CVastert SVotta BJBertin JWouters CHS100 proteinsBlau syndromeObjective. To identify biomarkers of articular and ocular disease activity in patients with Blau syndrome (BS) Methods. Multiplex plasma protein arrays were performed in five BS patients and eight normal healthy volunteers (NHVs). Plasma S100A12 and S100A8/9 were subsequently measured by ELISA at baseline and 1-year follow-up in all patients from a prospective multicentre cohort study. CRP was measured using Meso Scale Discovery immunoassay. Active joint counts, standardization uveitis nomenclature for anterior uveitis cells and vitreous haze by Nussenblatt scale were the clinical parameters. Results. Multiplex Luminex arrays identified S100A12 as the most significantly elevated protein in five selected BS vs eight NHVs and this was confirmed by ELISA on additional samples from the same five BS patients. In the patient cohort, S100A12 (n = 39) and S100A8/9 (n = 33) were significantly higher compared with NHVs (n = 44 for S100A12, n = 40 for S100A8/9) (P = 0.0000004 and P = 0.0003, respectively). Positive correlations between active joint counts and S100 levels were significant for S100A12 (P = 0.0008) and S100A8/9 (P = 0.015). CRP levels did not correlate with active joint count. Subgroup analysis showed significant association of S100 proteins with active arthritis (S100A12 P = 0.01, S100A8/9 P = 0.008). Active uveitis was not associated with increased S100 levels. Conclusion. S100 proteins are biomarkers of articular disease activity in BS and potential outcome measures in future clinical trials. As secreted neutrophil and macrophage products, S100 proteins may reflect the burden of granulomatous tissue in BS.OXFORD UNIV PRESS2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14191RHEUMATOLOGYISSN: 14620324ISSNe: 14620332reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p141912026-05-27T12:37:41Z
dc.title.none.fl_str_mv S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
title S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
spellingShingle S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
Wang L
S100 proteins
Blau syndrome
title_short S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
title_full S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
title_fullStr S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
title_full_unstemmed S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
title_sort S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
dc.creator.none.fl_str_mv Wang L
Rosé CD
Foley KP
Anton J
Bader-Meunier B
Brissaud P
Chédeville G
Cimaz R
Fernández-Martín J
Guly C
Hachulla E
Harjacek M
Mackensen F
Merino R
Modesto C
Naranjo Hernández A
Pajot C
Ramanan AV
Thatayatikom A
Thomée C
Vastert S
Votta BJ
Bertin J
Wouters CH
author Wang L
author_facet Wang L
Rosé CD
Foley KP
Anton J
Bader-Meunier B
Brissaud P
Chédeville G
Cimaz R
Fernández-Martín J
Guly C
Hachulla E
Harjacek M
Mackensen F
Merino R
Modesto C
Naranjo Hernández A
Pajot C
Ramanan AV
Thatayatikom A
Thomée C
Vastert S
Votta BJ
Bertin J
Wouters CH
author_role author
author2 Rosé CD
Foley KP
Anton J
Bader-Meunier B
Brissaud P
Chédeville G
Cimaz R
Fernández-Martín J
Guly C
Hachulla E
Harjacek M
Mackensen F
Merino R
Modesto C
Naranjo Hernández A
Pajot C
Ramanan AV
Thatayatikom A
Thomée C
Vastert S
Votta BJ
Bertin J
Wouters CH
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv S100 proteins
Blau syndrome
topic S100 proteins
Blau syndrome
description Objective. To identify biomarkers of articular and ocular disease activity in patients with Blau syndrome (BS) Methods. Multiplex plasma protein arrays were performed in five BS patients and eight normal healthy volunteers (NHVs). Plasma S100A12 and S100A8/9 were subsequently measured by ELISA at baseline and 1-year follow-up in all patients from a prospective multicentre cohort study. CRP was measured using Meso Scale Discovery immunoassay. Active joint counts, standardization uveitis nomenclature for anterior uveitis cells and vitreous haze by Nussenblatt scale were the clinical parameters. Results. Multiplex Luminex arrays identified S100A12 as the most significantly elevated protein in five selected BS vs eight NHVs and this was confirmed by ELISA on additional samples from the same five BS patients. In the patient cohort, S100A12 (n = 39) and S100A8/9 (n = 33) were significantly higher compared with NHVs (n = 44 for S100A12, n = 40 for S100A8/9) (P = 0.0000004 and P = 0.0003, respectively). Positive correlations between active joint counts and S100 levels were significant for S100A12 (P = 0.0008) and S100A8/9 (P = 0.015). CRP levels did not correlate with active joint count. Subgroup analysis showed significant association of S100 proteins with active arthritis (S100A12 P = 0.01, S100A8/9 P = 0.008). Active uveitis was not associated with increased S100 levels. Conclusion. S100 proteins are biomarkers of articular disease activity in BS and potential outcome measures in future clinical trials. As secreted neutrophil and macrophage products, S100 proteins may reflect the burden of granulomatous tissue in BS.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14191
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14191
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv RHEUMATOLOGY
ISSN: 14620324
ISSNe: 14620332
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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