The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis

[Introduction]: Ammonia is a pathogenic factor implicated in the progression of metabolic-associated steatotic liver disease (MASLD). The contribution of the glutaminase 1 (GLS) isoform, an enzyme converting glutamine to glutamate and ammonia, to hepatic ammonia build-up and the mechanisms underlyin...

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Detalles Bibliográficos
Autores: Mercado-Gómez, Maria, Goikoetxea-Usandizaga, Naroa, Kerbert, Annarein J.C., Uraga Gracianteparaluceta, Leire, Serrano-Maciá, Marina, Lachiondo-Ortega, Sofía, Rodríguez-Agudo, Rubén, Gil-Pitarch, Clàudia, Simón, Jorge, González-Recio, Irene, Fondevila, Marcos F., Santamarina-Ojeda, Pablo, Fraga, Mario F., Nogueiras, Rubén, Heras, Javier de las, Jalan, Rajiv, Martínez-Chantar, María Luz, Delgado, Teresa C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/376740
Acceso en línea:http://hdl.handle.net/10261/376740
Access Level:acceso abierto
Palabra clave:Ammonia
Glutaminase
Lipopolysaccharide
Metabolic-associated steatotic liver disease
Toll-like receptor 4
Urea cycle
Descripción
Sumario:[Introduction]: Ammonia is a pathogenic factor implicated in the progression of metabolic-associated steatotic liver disease (MASLD). The contribution of the glutaminase 1 (GLS) isoform, an enzyme converting glutamine to glutamate and ammonia, to hepatic ammonia build-up and the mechanisms underlying its upregulation in metabolic-associated steatohepatitis (MASH) remain elusive.

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