Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease
To evaluate the impact of comorbidities and extraintestinal manifestations of inflammatory bowel disease on the response of patients with inflammatory bowel disease to antitumour necrosis factor alpha (anti-TNFα) therapy. Data from 310 patients (194 with Crohn's disease and 116 with ulcerative...
| Autores: | , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:283891 |
| Acceso en línea: | https://ddd.uab.cat/record/283891 https://dx.doi.org/urn:doi:10.1136/bmjgast-2019-000351 |
| Access Level: | acceso abierto |
| Palabra clave: | Crohn's disease Immune response TNF-alpha Ulcerative colitis |
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Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel diseaseThe VERNE studyMarín Jiménez, Ignacio|||0000-0001-5424-2484Bastida Paz, Guillermo|||0000-0001-7544-451XForés, AnaGarcía-Planella, Esther|||0000-0002-4325-0697Argüelles-Arias, Federico|||0000-0003-3646-8919Sarasa, PilarTagarro, IgnacioFernández-Nistal, AlonsoMontoto, CarmenAguas, Mariam|||0000-0003-4353-569XSantos-Fernandez, Javier|||0000-0003-4576-7566Bosca-Watts, Marta Maia|||0000-0001-7495-8797Ferreiro Iglesias, Rocío|||0000-0002-0469-4332Merino, Olga|||0000-0002-1362-4475Aldeguer, Xavier|||0000-0003-4597-8339Cortés Rizo, XavierSicilia Aladrén, Beatriz|||0000-0002-4495-9358Mesonero, Francisco|||0000-0002-7864-8187Barreiro de-Acosta, Manuel|||0000-0001-5915-1477Crohn's diseaseImmune responseTNF-alphaUlcerative colitisTo evaluate the impact of comorbidities and extraintestinal manifestations of inflammatory bowel disease on the response of patients with inflammatory bowel disease to antitumour necrosis factor alpha (anti-TNFα) therapy. Data from 310 patients (194 with Crohn's disease and 116 with ulcerative colitis) treated consecutively with the first anti-TNFα in 24 Spanish hospitals were retrospectively analysed. Univariate and multivariate logistic regression analyses were performed to assess the associations between inflammatory bowel disease comorbidities and extraintestinal manifestations with anti-TNFα treatment outcomes. Key clinical features, such as type of inflammatory bowel disease and concomitant treatments, were included as fixed factors in the model. Multivariate logistic regression analyses (OR, 95% CI) showed that chronic obstructive pulmonary disease (2.67, 1.33 to 5.35) and hepato-pancreato-biliary diseases (1.87, 1.48 to 2.36) were significantly associated with primary non-response to anti-TNFα, as was the use of corticosteroids and the type of inflammatory bowel disease (ulcerative colitis vs Crohn's disease). It was also found that myocardial infarction (3.30, 1.48 to 7.35) and skin disease (2.73, 1.42 to 5.25) were significantly associated with loss of response, along with the use of corticosteroids and the type of inflammatory bowel disease (ulcerative colitis vs Crohn's disease). Our results suggest that the presence of some comorbidities in patients with inflammatory bowel disease, such as chronic obstructive pulmonary disease and myocardial infarction, and of certain extraintestinal manifestations of inflammatory bowel disease, such as hepato-pancreato-biliary conditions and skin diseases, appear to be related to failure to anti-TNFα treatment. Therefore, their presence should be considered when choosing a treatment.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/283891https://dx.doi.org/urn:doi:10.1136/bmjgast-2019-000351reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2838912026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease The VERNE study |
| title |
Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease |
| spellingShingle |
Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease Marín Jiménez, Ignacio|||0000-0001-5424-2484 Crohn's disease Immune response TNF-alpha Ulcerative colitis |
| title_short |
Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease |
| title_full |
Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease |
| title_fullStr |
Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease |
| title_full_unstemmed |
Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease |
| title_sort |
Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease |
| dc.creator.none.fl_str_mv |
Marín Jiménez, Ignacio|||0000-0001-5424-2484 Bastida Paz, Guillermo|||0000-0001-7544-451X Forés, Ana García-Planella, Esther|||0000-0002-4325-0697 Argüelles-Arias, Federico|||0000-0003-3646-8919 Sarasa, Pilar Tagarro, Ignacio Fernández-Nistal, Alonso Montoto, Carmen Aguas, Mariam|||0000-0003-4353-569X Santos-Fernandez, Javier|||0000-0003-4576-7566 Bosca-Watts, Marta Maia|||0000-0001-7495-8797 Ferreiro Iglesias, Rocío|||0000-0002-0469-4332 Merino, Olga|||0000-0002-1362-4475 Aldeguer, Xavier|||0000-0003-4597-8339 Cortés Rizo, Xavier Sicilia Aladrén, Beatriz|||0000-0002-4495-9358 Mesonero, Francisco|||0000-0002-7864-8187 Barreiro de-Acosta, Manuel|||0000-0001-5915-1477 |
| author |
Marín Jiménez, Ignacio|||0000-0001-5424-2484 |
| author_facet |
Marín Jiménez, Ignacio|||0000-0001-5424-2484 Bastida Paz, Guillermo|||0000-0001-7544-451X Forés, Ana García-Planella, Esther|||0000-0002-4325-0697 Argüelles-Arias, Federico|||0000-0003-3646-8919 Sarasa, Pilar Tagarro, Ignacio Fernández-Nistal, Alonso Montoto, Carmen Aguas, Mariam|||0000-0003-4353-569X Santos-Fernandez, Javier|||0000-0003-4576-7566 Bosca-Watts, Marta Maia|||0000-0001-7495-8797 Ferreiro Iglesias, Rocío|||0000-0002-0469-4332 Merino, Olga|||0000-0002-1362-4475 Aldeguer, Xavier|||0000-0003-4597-8339 Cortés Rizo, Xavier Sicilia Aladrén, Beatriz|||0000-0002-4495-9358 Mesonero, Francisco|||0000-0002-7864-8187 Barreiro de-Acosta, Manuel|||0000-0001-5915-1477 |
| author_role |
author |
| author2 |
Bastida Paz, Guillermo|||0000-0001-7544-451X Forés, Ana García-Planella, Esther|||0000-0002-4325-0697 Argüelles-Arias, Federico|||0000-0003-3646-8919 Sarasa, Pilar Tagarro, Ignacio Fernández-Nistal, Alonso Montoto, Carmen Aguas, Mariam|||0000-0003-4353-569X Santos-Fernandez, Javier|||0000-0003-4576-7566 Bosca-Watts, Marta Maia|||0000-0001-7495-8797 Ferreiro Iglesias, Rocío|||0000-0002-0469-4332 Merino, Olga|||0000-0002-1362-4475 Aldeguer, Xavier|||0000-0003-4597-8339 Cortés Rizo, Xavier Sicilia Aladrén, Beatriz|||0000-0002-4495-9358 Mesonero, Francisco|||0000-0002-7864-8187 Barreiro de-Acosta, Manuel|||0000-0001-5915-1477 |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Crohn's disease Immune response TNF-alpha Ulcerative colitis |
| topic |
Crohn's disease Immune response TNF-alpha Ulcerative colitis |
| description |
To evaluate the impact of comorbidities and extraintestinal manifestations of inflammatory bowel disease on the response of patients with inflammatory bowel disease to antitumour necrosis factor alpha (anti-TNFα) therapy. Data from 310 patients (194 with Crohn's disease and 116 with ulcerative colitis) treated consecutively with the first anti-TNFα in 24 Spanish hospitals were retrospectively analysed. Univariate and multivariate logistic regression analyses were performed to assess the associations between inflammatory bowel disease comorbidities and extraintestinal manifestations with anti-TNFα treatment outcomes. Key clinical features, such as type of inflammatory bowel disease and concomitant treatments, were included as fixed factors in the model. Multivariate logistic regression analyses (OR, 95% CI) showed that chronic obstructive pulmonary disease (2.67, 1.33 to 5.35) and hepato-pancreato-biliary diseases (1.87, 1.48 to 2.36) were significantly associated with primary non-response to anti-TNFα, as was the use of corticosteroids and the type of inflammatory bowel disease (ulcerative colitis vs Crohn's disease). It was also found that myocardial infarction (3.30, 1.48 to 7.35) and skin disease (2.73, 1.42 to 5.25) were significantly associated with loss of response, along with the use of corticosteroids and the type of inflammatory bowel disease (ulcerative colitis vs Crohn's disease). Our results suggest that the presence of some comorbidities in patients with inflammatory bowel disease, such as chronic obstructive pulmonary disease and myocardial infarction, and of certain extraintestinal manifestations of inflammatory bowel disease, such as hepato-pancreato-biliary conditions and skin diseases, appear to be related to failure to anti-TNFα treatment. Therefore, their presence should be considered when choosing a treatment. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2 2020-01-01 2020 2020-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/283891 https://dx.doi.org/urn:doi:10.1136/bmjgast-2019-000351 |
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https://ddd.uab.cat/record/283891 https://dx.doi.org/urn:doi:10.1136/bmjgast-2019-000351 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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