Parkinson's disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation. We use Mendelian randomization to investigate over 3,000 genes that encode druggable proteins and predict...
Detalles Bibliográficos
| Autores: |
Storm, Catherine|||0000-0003-4957-1712,
Kia, Demis A.,
Almramhi, Mona M.,
Bandres-Ciga, Sara|||0000-0003-0056-1361,
Finan, Chris|||0000-0002-3319-1937,
Noyce, Alastair J.,
Kaiyrzhanov, Rauan|||0000-0003-1640-4010,
Middlehurst, Ben,
Tan, Manuela|||0000-0001-5835-669X,
Houlden, Henry|||0000-0002-2866-7777,
Morris, Huw|||0000-0002-5473-3774,
Plun-Favreau, Helene,
Holmans, Peter|||0000-0003-0870-9412,
Hardy, John|||0000-0002-3122-0423,
Trabzuni, Daniah|||0000-0003-4826-9570,
Quinn, John,
Bubb, Vivien,
Mok, Kin Y.,
Kinghorn, Kerri J.|||0000-0003-2048-4332,
Lewis, Patrick|||0000-0003-4537-0489,
Schreglmann, Sebastian R.,
Lovering, Ruth,
R'Bibo, Lea,
Manzoni, Claudia|||0000-0001-5367-4023,
Rizig, Mie|||0000-0003-2420-4449,
Ryten, Mina,
Guelfi, Sebastian,
Escott-Price, Valentina|||0000-0003-1784-5483,
Chelban, Viorica|||0000-0002-5817-6290,
Foltynie, Thomas|||0000-0003-0752-1813,
Williams, Nigel,
Morrison, Karen E.|||0000-0003-0216-5717,
Clarke, Car,
Harvey, Kirsten,
Jacobs, Benjamin M.,
Brice, Alexis|||0000-0002-0941-3990,
Danjou, Fabrice|||0000-0002-4976-2327,
Lesage, Suzanne,
Corvol, Jean-Christophe|||0000-0001-7325-0199,
Martinez, Maria,
Schulte, Claudia|||0000-0003-4006-1265,
Brockmann, Kathrin|||0000-0002-7515-8596,
Simón-Sánchez, Javier,
Heutink, Peter|||0000-0001-5218-1737,
Rizzu, Patrizia,
Sharma, Manu,
Gasser, Thomas|||0000-0003-4882-2647,
Schneider, Susanne A.,
Cookson, Mark R.,
Blauwendraat, Cornelis|||0000-0001-9358-8111,
Craig, David W.|||0000-0003-2040-1955,
Billingsley, Kimberley,
Makarious, Mary B.,
Narendra, Derek P.,
Faghri, Faraz,
Gibbs, J. Raphael|||0000-0002-6985-0658,
Hernández, Dena G.,
Van Keuren-Jensen, K.,
Shulman, Joshua M.,
Iwaki, Hirotaka,
Leonard, Hampton L.|||0000-0003-2390-8110,
Nalls, Mike A.,
Robak, Laurie,
Bras, Jose|||0000-0001-8186-0333,
Guerreiro, Rita|||0000-0001-5879-3486,
Lubbe, Steven,
Troycoco, Timothy,
Finkbeiner, Steven,
Mencacci, Niccolo E.,
Lungu, Codrin,
Singleton, Andrew B.|||0000-0001-5606-700X,
Scholz, Sonja|||0000-0002-6623-0429,
Reed, Xylena,
Uitti, Ryan J.,
Ross, Owen A.|||0000-0003-4813-756X,
Grenn, Francis P.,
Moore, Anni,
Alcalay, Roy N.,
Wszolek, Zbigniew K.|||0000-0001-5487-1053,
Gan-Or, Ziv|||0000-0003-0332-234X,
Rouleau, Guy A.|||0000-0001-8403-1418,
Krohn, Lynne|||0000-0001-6554-1666,
Mufti, Kheireddin,
van Hilten, Jacobus J.,
Marinus, Johan,
Adarmes-Gómez, A.D.|||0000-0002-1337-9289,
Aguilar Barberà, Miquel,
Alvarez, Ignacio|||0000-0002-8537-3935,
Alvarez, Victoria|||0000-0002-1916-2523,
Barrero, Francisco Javier,
Yarza, Jesús Alberto Bergareche,
Bernal-Bernal, Inmaculada,
Blázquez Estrada, Marta|||0000-0003-3348-9992,
Bonilla-Toribio, Marta,
Botía, Juan A.|||0000-0002-6992-598X,
Boungiorno, María Teresa,
Buiza-Rueda, Dolores|||0000-0002-3504-9299,
Cámara, Ana|||0000-0002-8005-9461,
Carrillo, Fátima,
Carrión-Claro, M.,
Cerdan, Debora|||0000-0001-5408-691X,
Clarimón, Jordi|||0000-0002-6824-6942,
Compta, Yaroslau|||0000-0001-6443-0104,
Diez-Fairen, Monica|||0000-0003-1882-0309,
Dols Icardo, Oriol|||0000-0003-2656-8748,
Duarte, Jacinto,
Duran, Raquel,
Escamilla Sevilla, Francisco|||0000-0003-2149-2668,
Ezquerra, Mario|||0000-0003-3246-6641,
Feliz, Cici,
Fernández, Manel,
Fernández-Santiago, Rubén|||0000-0002-4582-0702,
Garcia, Ciara,
García-Ruiz, Pedro,
Gómez-Garre, Pilar|||0000-0002-0437-6182,
Gomez Heredia, Maria Jose,
Gonzalez-Aramburu, Isabel|||0000-0002-3696-4093,
Gorostidi Pagola, Ana,
Hoenicka, Janet|||0000-0002-6790-6988,
Infante, Jon|||0000-0003-4025-4606,
Jesús, Silvia,
Jiménez-Escrig, Adriano|||0000-0002-4927-1886,
Kulisevsky, Jaime|||0000-0003-4870-1431,
Labrador-Espinosa, Miguel A.|||0000-0003-3576-1777,
López-Sendon, Jose Luis,
López de Munain Arregui, Adolfo,
Macías-García, Daniel|||0000-0002-4822-1529,
Martínez Torres, Irene,
Marín, Juan,
Marti, María José,
Martínez-Castrillo, Juan Carlos|||0000-0001-7744-6850,
Méndez-del-Barrio, Carlota,
Menéndez González, Manuel,
Mata, Marina|||0000-0001-9693-7663,
Mínguez, Adolfo M.,
Mir, Pablo|||0000-0003-1656-302X,
Mondragon Rezola, Elisabet,
Muñoz, Esteban,
Pagonabarraga Mora, Javier|||0000-0002-3248-704X,
Pastor, Pau|||0000-0002-7493-8777,
Perez-Errazquin, Francisco,
Periñán-Tocino, Teresa,
Ruiz-Martínez, Javier,
Ruz, Clara,
Sánchez Rodríguez, Antonio,
Sierra, Maria,
Suarez-Sanmartin, Esther,
Tabernero, Cesar,
Tartari, Juan Pablo,
Tejera-Parrado, Cristina|||0000-0001-8001-5621,
Tolosa, Eduard|||0000-0001-6608-3038,
Valldeoriola, Francesc|||0000-0002-8680-4274,
Vargas-González, Laura,
Vela, Lydia|||0000-0001-6663-395X,
Vives, Francisco,
Zimprich, Alexander|||0000-0002-1668-5177,
Pihlstrom, Lasse,
Toft, Mathias|||0000-0002-6723-6865,
Taba, Pille|||0000-0002-1315-1065,
Koks, Sulev,
Hassin-Baer, Sharon,
Majamaa, Kari|||0000-0002-9070-3791,
Siitonen, Ari,
Tienari, Pentti,
Okubadejo, Njideka U.,
Ojo, Oluwadamilola O.,
Shashkin, Chingiz,
Zharkinbekova, Nazira,
Akhmetzhanov, Vadim,
Kaishybayeva, Gulnaz,
Karimova, Altynay,
Khaibullin, Talgat,
Lynch, Timothy L.,
Hingorani, Aroon|||0000-0001-8365-0081,
Wood, Nicholas W.|||0000-0002-9500-3348 |
|---|
| Tipo de recurso: | artículo
|
|---|
| Fecha de publicación: | 2021 |
|---|
| País: | España |
|---|
| Institución: | Universitat Autònoma de Barcelona |
|---|
| Repositorio: | Dipòsit Digital de Documents de la UAB |
|---|
| Idioma: | inglés |
|---|
| OAI Identifier: | oai:ddd.uab.cat:264453 |
|---|
| Acceso en línea: | https://ddd.uab.cat/record/264453
https://dx.doi.org/urn:doi:10.1038/s41467-021-26280-1
|
|---|
| Access Level: | acceso abierto |
|---|
| Palabra clave: | Brain
Case-Control Studies
Cohort Studies
Disease Progression
Gene Expression Regulation
Genetic Predisposition to Disease
Genetic Variation
Genome, Human
Humans
Mendelian Randomization Analysis
Parkinson Disease
Quantitative Trait Loci
Risk Factors |
|---|
