Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila

The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of th...

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Detalles Bibliográficos
Autores: Camilleri Robles, Carlos, Serras Rigalt, Florenci, Corominas, Montserrat (Corominas Guiu)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176303
Acceso en línea:https://hdl.handle.net/2445/176303
Access Level:acceso abierto
Palabra clave:Proteïnes G
ADN
Drosòfila
G Proteins
DNA
Drosophila
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spelling Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in DrosophilaCamilleri Robles, CarlosSerras Rigalt, FlorenciCorominas, Montserrat (Corominas Guiu)Proteïnes GADNDrosòfilaG ProteinsDNADrosophilaThe GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176303Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/genes10050378Genes, 2019, vol. 10, num. 5, p. 378https://doi.org/10.3390/genes10050378cc-by (c) Camilleri Robles, Carlos et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1763032026-05-27T06:46:51Z
dc.title.none.fl_str_mv Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
title Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
spellingShingle Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
Camilleri Robles, Carlos
Proteïnes G
ADN
Drosòfila
G Proteins
DNA
Drosophila
title_short Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
title_full Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
title_fullStr Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
title_full_unstemmed Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
title_sort Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
dc.creator.none.fl_str_mv Camilleri Robles, Carlos
Serras Rigalt, Florenci
Corominas, Montserrat (Corominas Guiu)
author Camilleri Robles, Carlos
author_facet Camilleri Robles, Carlos
Serras Rigalt, Florenci
Corominas, Montserrat (Corominas Guiu)
author_role author
author2 Serras Rigalt, Florenci
Corominas, Montserrat (Corominas Guiu)
author2_role author
author
dc.subject.none.fl_str_mv Proteïnes G
ADN
Drosòfila
G Proteins
DNA
Drosophila
topic Proteïnes G
ADN
Drosòfila
G Proteins
DNA
Drosophila
description The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176303
url https://hdl.handle.net/2445/176303
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/genes10050378
Genes, 2019, vol. 10, num. 5, p. 378
https://doi.org/10.3390/genes10050378
dc.rights.none.fl_str_mv cc-by (c) Camilleri Robles, Carlos et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Camilleri Robles, Carlos et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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