Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate

Type II reference isolates of Toxoplasma gondii are widely used in animal toxoplasmosis models, but studies with Type III isolates remain scarce. In addition, these methods often rely on laboratory-adapted parasite stages that may not reflect natural infection. This study presents a new murine model...

Descripción completa

Detalles Bibliográficos
Autores: Largo de la Torre, Andrea, Ferré Pérez, Ignacio, Sánchez Sánchez, Roberto, Regidor Cerrillo, Javier, Ortega Mora, Luis Miguel
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/120104
Acceso en línea:https://hdl.handle.net/20.500.14352/120104
Access Level:acceso abierto
Palabra clave:636.09
Toxoplasma gondii
Mouse model
Oocyst
Type II and Type III
Feld isolate
Veterinaria
3109 Ciencias Veterinarias
id ES_a08015f79d0e5758d16d201fed0903e6
oai_identifier_str oai:docta.ucm.es:20.500.14352/120104
network_acronym_str ES
network_name_str España
repository_id_str
spelling Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolateLargo de la Torre, AndreaFerré Pérez, IgnacioSánchez Sánchez, RobertoRegidor Cerrillo, JavierOrtega Mora, Luis Miguel636.09Toxoplasma gondiiMouse modelOocystType II and Type IIIFeld isolateVeterinaria3109 Ciencias VeterinariasType II reference isolates of Toxoplasma gondii are widely used in animal toxoplasmosis models, but studies with Type III isolates remain scarce. In addition, these methods often rely on laboratory-adapted parasite stages that may not reflect natural infection. This study presents a new murine model based on an oral infection with oocysts from a recently obtained Type III isolate, TgShSp24, which exhibited remarkable morbidity and a distinct tissue distribution during chronic infection, differing from the recently obtained Type II isolate TgShSp1. This novel model aims to better mimic natural infection and provides a valuable tool for testing drugs and vaccines.SpringerUniversidad Complutense de Madrid20252025-04-0220252025-04-02journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/120104reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1201042026-06-02T12:44:21Z
dc.title.none.fl_str_mv Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
title Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
spellingShingle Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
Largo de la Torre, Andrea
636.09
Toxoplasma gondii
Mouse model
Oocyst
Type II and Type III
Feld isolate
Veterinaria
3109 Ciencias Veterinarias
title_short Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
title_full Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
title_fullStr Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
title_full_unstemmed Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
title_sort Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
dc.creator.none.fl_str_mv Largo de la Torre, Andrea
Ferré Pérez, Ignacio
Sánchez Sánchez, Roberto
Regidor Cerrillo, Javier
Ortega Mora, Luis Miguel
author Largo de la Torre, Andrea
author_facet Largo de la Torre, Andrea
Ferré Pérez, Ignacio
Sánchez Sánchez, Roberto
Regidor Cerrillo, Javier
Ortega Mora, Luis Miguel
author_role author
author2 Ferré Pérez, Ignacio
Sánchez Sánchez, Roberto
Regidor Cerrillo, Javier
Ortega Mora, Luis Miguel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.09
Toxoplasma gondii
Mouse model
Oocyst
Type II and Type III
Feld isolate
Veterinaria
3109 Ciencias Veterinarias
topic 636.09
Toxoplasma gondii
Mouse model
Oocyst
Type II and Type III
Feld isolate
Veterinaria
3109 Ciencias Veterinarias
description Type II reference isolates of Toxoplasma gondii are widely used in animal toxoplasmosis models, but studies with Type III isolates remain scarce. In addition, these methods often rely on laboratory-adapted parasite stages that may not reflect natural infection. This study presents a new murine model based on an oral infection with oocysts from a recently obtained Type III isolate, TgShSp24, which exhibited remarkable morbidity and a distinct tissue distribution during chronic infection, differing from the recently obtained Type II isolate TgShSp1. This novel model aims to better mimic natural infection and provides a valuable tool for testing drugs and vaccines.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-04-02
2025
2025-04-02
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/120104
url https://hdl.handle.net/20.500.14352/120104
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415016309981184
score 15,812429

Similares en LA Referencia