| Sumario: | The current gold standard assessment of human inspiratory muscle function involves using invasive measures of transdiaphragmatic pressure (P-di) or crural diaphragm electromyography (oesEMG(di)). Mechanomyography is a non-invasive measure of muscle vibration associated with muscle contraction. Surface electromyogram and mechanomyogram, recorded transcutaneously using sensors placed over the lower intercostal spaces (sEMG(lic) and sMMG(lic) respectively), have been proposed to provide non-invasive indices of inspiratory muscle activation, but have not been directly compared to gold standard Pdi and oesEMG(di) measures during voluntary respiratory manoeuvres. To validate the non-invasive techniques, the relationships between Pdi and sMMG(lic), and between oesEMG(di) and sEMG(lic) were measured simultaneously in 12 healthy subjects during an incremental inspiratory threshold loading protocol. Myographic signals were analysed using fixed sample entropy (fSampEn), which is less influenced by cardiac artefacts than conventional root mean square. Strong correlations were observed between: mean Pdi and mean fSampEn |sMMG(lic)| (left, 0.76; right, 0.81), the time-integrals of the Pdi and fSampEn |sMMG(lic)| (left, 0.78; right, 0.83), and mean fSampEn oesEMG(di) and mean fSampEn sEMG(lic) (left, 0.84; right, 0.83). These findings suggest that sMMG(lic) and sEMGlic could provide useful non-invasive alternatives to P-di and oesEMG(di) for the assessment of inspiratory muscle function in health and disease.
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