From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment

Recent advancements in mass spectrometry have significantly enhanced our understanding of complex lipid profiles, opening new avenues for oncological diagnostics. This review highlights the importance of lipidomics in the comprehension of certain metabolic pathways and its potential for the detectio...

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Autores: Díaz Grijuela, Elisa, Hernández, Agustín, Caballero, Claudia, Fernández, Roberto, Urtasun Alonso, Raquel, Gulak, Marina, Astigarraga, Egoitz, Barajas Vélez, Miguel Ángel, Barreda-Gómez, Gabriel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad San Jorge (USJ)
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/52140
Acceso en línea:https://hdl.handle.net/2454/52140
Access Level:acceso abierto
Palabra clave:Comparative oncology
Lipidomics
Liquid biopsy
Mass spectrometry
Melanoma
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spelling From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatmentDíaz Grijuela, ElisaHernández, AgustínCaballero, ClaudiaFernández, RobertoUrtasun Alonso, RaquelGulak, MarinaAstigarraga, EgoitzBarajas Vélez, Miguel ÁngelBarreda-Gómez, GabrielComparative oncologyLipidomicsLiquid biopsyMass spectrometryMelanomaRecent advancements in mass spectrometry have significantly enhanced our understanding of complex lipid profiles, opening new avenues for oncological diagnostics. This review highlights the importance of lipidomics in the comprehension of certain metabolic pathways and its potential for the detection and characterization of various cancers, in particular melanoma. Through detailed case studies, we demonstrate how lipidomic analysis has led to significant breakthroughs in the identification and understanding of cancer types and its potential for detecting unique biomarkers that are instrumental in its diagnosis. Additionally, this review addresses the technical challenges and future perspectives of these methodologies, including their potential expansion and refinement for clinical applications. The discussion underscores the critical role of lipidomic profiling in advancing cancer diagnostics, proposing a new paradigm in how we approach this devastating disease, with particular emphasis on its application in comparative oncology.This work received funding from Government of Navarra through grants 0011-1408-2023-000010 (Industrial PhD fellowship, E.D.-G.), and 0011-1365-2023-000241 (Onkomics, E.A.), and from the Spanish Ministry of Science and Innovation, co-financed with NextGenerationEU funds, through grant EXP-00151643/SNEO-20222260 (Neotec, Betternostics S.L.)MDPICiencias de la SaludOsasun Zientziak2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/52140reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad San Jorge (USJ)Inglésinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1408-2023-000010info:eu-repo/grantAgreement/Gobierno de Navarra//0011-1365-2023-000241© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/521402026-06-17T12:41:47Z
dc.title.none.fl_str_mv From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment
title From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment
spellingShingle From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment
Díaz Grijuela, Elisa
Comparative oncology
Lipidomics
Liquid biopsy
Mass spectrometry
Melanoma
title_short From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment
title_full From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment
title_fullStr From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment
title_full_unstemmed From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment
title_sort From lipid signatures to cellular responses: unraveling the complexity of melanoma and furthering its diagnosis and treatment
dc.creator.none.fl_str_mv Díaz Grijuela, Elisa
Hernández, Agustín
Caballero, Claudia
Fernández, Roberto
Urtasun Alonso, Raquel
Gulak, Marina
Astigarraga, Egoitz
Barajas Vélez, Miguel Ángel
Barreda-Gómez, Gabriel
author Díaz Grijuela, Elisa
author_facet Díaz Grijuela, Elisa
Hernández, Agustín
Caballero, Claudia
Fernández, Roberto
Urtasun Alonso, Raquel
Gulak, Marina
Astigarraga, Egoitz
Barajas Vélez, Miguel Ángel
Barreda-Gómez, Gabriel
author_role author
author2 Hernández, Agustín
Caballero, Claudia
Fernández, Roberto
Urtasun Alonso, Raquel
Gulak, Marina
Astigarraga, Egoitz
Barajas Vélez, Miguel Ángel
Barreda-Gómez, Gabriel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Comparative oncology
Lipidomics
Liquid biopsy
Mass spectrometry
Melanoma
topic Comparative oncology
Lipidomics
Liquid biopsy
Mass spectrometry
Melanoma
description Recent advancements in mass spectrometry have significantly enhanced our understanding of complex lipid profiles, opening new avenues for oncological diagnostics. This review highlights the importance of lipidomics in the comprehension of certain metabolic pathways and its potential for the detection and characterization of various cancers, in particular melanoma. Through detailed case studies, we demonstrate how lipidomic analysis has led to significant breakthroughs in the identification and understanding of cancer types and its potential for detecting unique biomarkers that are instrumental in its diagnosis. Additionally, this review addresses the technical challenges and future perspectives of these methodologies, including their potential expansion and refinement for clinical applications. The discussion underscores the critical role of lipidomic profiling in advancing cancer diagnostics, proposing a new paradigm in how we approach this devastating disease, with particular emphasis on its application in comparative oncology.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/52140
url https://hdl.handle.net/2454/52140
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/Gobierno de Navarra//0011-1408-2023-000010
info:eu-repo/grantAgreement/Gobierno de Navarra//0011-1365-2023-000241
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad San Jorge (USJ)
instname_str Universidad San Jorge (USJ)
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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