Origin, Development, and Synaptogenesis of Cortical Interneurons

The mammalian cerebral cortex represents one of the most recent and astonishing inventions of nature, responsible of a large diversity of functions that range from sensory processing to high-order cognitive abilities, such as logical reasoning or language. Decades of dedicated study have contributed...

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Detalles Bibliográficos
Autores: Llorca, Alfredo, Deogracias, Ruben
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154866
Acceso en línea:http://hdl.handle.net/10366/154866
Access Level:acceso abierto
Palabra clave:brain
cell death
cortex
development
interneuron
neuron
synaptogenesis
Interneurons
Cerebral Cortex
Cell Death
Brain
Neurons
Synapsins
3205.07 Neurología
Descripción
Sumario:The mammalian cerebral cortex represents one of the most recent and astonishing inventions of nature, responsible of a large diversity of functions that range from sensory processing to high-order cognitive abilities, such as logical reasoning or language. Decades of dedicated study have contributed to our current understanding of this structure, both at structural and functional levels. A key feature of the neocortex is its outstanding richness in cell diversity, composed by multiple types of long-range projecting neurons and locally connecting interneurons. In this review, we will describe the great diversity of interneurons that constitute local neocortical circuits and summarize the mechanisms underlying their development and their assembly into functional networks.