In-vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: imaging results from the COPPADIS study.

Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who unde...

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Detalles Bibliográficos
Autores: Grothe, Michel J., Labrador Espinosa, M. A, Jesús, Silvia, Macías García, Daniel, Adarmes Gómez, Astrid, Carrillo, Fátima, Iglesias Camacho, Elena, Franco Rosado, Pablo, Roldán Lora, Florinda, Martín Rodríguez, Juan Francisco, Aguilar Barberá, Miquel, Escalante Arroyo, Sonia, Solano Vila, Berta, de Deus Fonticoba, Teresa, Carrillo Padilla, Francisco, Infante Ceberio, Jon, Hernández Vara, Jorge, de Fábregues Boixar, Oriol, Kulisevsky, Jaime, Martínez Martín, Pablo, Santos García, Diego, Mir, Pablo, Pastor, Pau, Ruíz Martínez, Javier, Cots Foraster, Anna, Pueyo Morlans, Mercedes, Pascual Sedano, Berta, González Aramburu, Isabel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/180205
Acceso en línea:https://hdl.handle.net/2445/180205
Access Level:acceso abierto
Palabra clave:Malaltia de Parkinson
Parkinson's disease
Descripción
Sumario:Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r = 0.37, p < 0.001), and this association remained significant after controlling for several potential confounding variables (p = 0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p = 0.02). Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD.

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