Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.

Campana M; Yakimov V; Moussiopoulou J; Maurus I; Löhrs L; Raabe F; Jäger I; Mortazavi M; Benros ME; Jeppesen R; Meyer Zu Hörste G; Heming M; Giné-Servén E; Labad J; Boix E; Lennox B; Yeeles K; Steiner J; Meyer-Lotz G; Dobrowolny H; Malchow B; Hansen N; Falkai P; Siafis S; Leucht S; Halstead S; Warren N; Siskind D; Strube W; Hasan A; Wagner E

Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.

Neuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorders(SSDs) etiology and symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and...

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Autores:	Campana M, Yakimov V, Moussiopoulou J, Maurus I, Löhrs L, Raabe F, Jäger I, Mortazavi M, Benros ME, Jeppesen R, Meyer Zu Hörste G, Heming M, Giné-Servén E, Labad J, Boix E, Lennox B, Yeeles K, Steiner J, Meyer-Lotz G, Dobrowolny H, Malchow B, Hansen N, Falkai P, Siafis S, Leucht S, Halstead S, Warren N, Siskind D, Strube W, Hasan A, Wagner E
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2024
País:	España
Institución:	Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:	oai:i3pt.fundanetsuite.com:p5448
Acceso en línea:	https://i3pt.portalinvestigacion.com/publicaciones/5448 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190358142&doi=10.1016%2fj.bbi.2024.04.011&partnerID=40&md5=90dc41ce538ec6c171edef40b8f892c9
Access Level:	acceso abierto
Palabra clave:	Blood–brain barrier, CSF, First episode psychosis, Individual patient data, Meta-analysis, Schizophrenia spectrum disorders

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spelling	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.Campana MYakimov VMoussiopoulou JMaurus ILöhrs LRaabe FJäger IMortazavi MBenros MEJeppesen RMeyer Zu Hörste GHeming MGiné-Servén ELabad JBoix ELennox BYeeles KSteiner JMeyer-Lotz GDobrowolny HMalchow BHansen NFalkai PSiafis SLeucht SHalstead SWarren NSiskind DStrube WHasan AWagner EBlood–brain barrier, CSF, First episode psychosis, Individual patient data, Meta-analysis, Schizophrenia spectrum disordersNeuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorders(SSDs) etiology and symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases. FEP, ROP and high-risk syndromes for psychosis IPD were included if routine basic CSF-diagnostics were reported. Risk of bias of the included studies was evaluated. Random-effects meta-analyses and mixed-effects linear regression models were employed to assess the impact of BCB alterations on symptom severity. Published (6 studies) and unpublished IPD from n = 531 individuals was included in the analyses. CSF was altered in 38.8 % of individuals. No significant differences in symptom severity were found between individuals with and without CSF alterations (SMD = -0.17, 95 %CI -0.55-0.22, p = 0.341). However, males with elevated CSF/serum albumin ratios or any CSF alteration had significantly higher positive symptom scores than those without alterations (SMD = 0.34, 95 %CI 0.05-0.64, p = 0.037 and SMD = 0.29, 95 %CI 0.17-0.41p = 0.005, respectively). Mixed-effects and simple regression models showed no association (p > 0.1) between CSF parameters and symptomatic outcomes. No interaction between sex and CSF parameters was found (p > 0.1). BCB disruption appears highly prevalent in early psychosis and could be involved in positive symptoms severity in males, indicating potential difficult-to-treat states. This work highlights the need for considering BCB breakdownand sex-related differences in SSDs clinical trials and treatment strategies.ACADEMIC PRESS INC ELSEVIER SCIENCE2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/5448https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190358142&doi=10.1016%2fj.bbi.2024.04.011&partnerID=40&md5=90dc41ce538ec6c171edef40b8f892c9BRAIN BEHAVIOR AND IMMUNITYISSN: 08891591ISSNe: 10902139reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p54482026-06-21T15:30:37Z
dc.title.none.fl_str_mv	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.
title	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.
spellingShingle	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis. Campana M Blood–brain barrier, CSF, First episode psychosis, Individual patient data, Meta-analysis, Schizophrenia spectrum disorders
title_short	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.
title_full	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.
title_fullStr	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.
title_full_unstemmed	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.
title_sort	Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.
dc.creator.none.fl_str_mv	Campana M Yakimov V Moussiopoulou J Maurus I Löhrs L Raabe F Jäger I Mortazavi M Benros ME Jeppesen R Meyer Zu Hörste G Heming M Giné-Servén E Labad J Boix E Lennox B Yeeles K Steiner J Meyer-Lotz G Dobrowolny H Malchow B Hansen N Falkai P Siafis S Leucht S Halstead S Warren N Siskind D Strube W Hasan A Wagner E
author	Campana M
author_facet	Campana M Yakimov V Moussiopoulou J Maurus I Löhrs L Raabe F Jäger I Mortazavi M Benros ME Jeppesen R Meyer Zu Hörste G Heming M Giné-Servén E Labad J Boix E Lennox B Yeeles K Steiner J Meyer-Lotz G Dobrowolny H Malchow B Hansen N Falkai P Siafis S Leucht S Halstead S Warren N Siskind D Strube W Hasan A Wagner E
author_role	author
author2	Yakimov V Moussiopoulou J Maurus I Löhrs L Raabe F Jäger I Mortazavi M Benros ME Jeppesen R Meyer Zu Hörste G Heming M Giné-Servén E Labad J Boix E Lennox B Yeeles K Steiner J Meyer-Lotz G Dobrowolny H Malchow B Hansen N Falkai P Siafis S Leucht S Halstead S Warren N Siskind D Strube W Hasan A Wagner E
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Blood–brain barrier, CSF, First episode psychosis, Individual patient data, Meta-analysis, Schizophrenia spectrum disorders
topic	Blood–brain barrier, CSF, First episode psychosis, Individual patient data, Meta-analysis, Schizophrenia spectrum disorders
description	Neuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorders(SSDs) etiology and symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases. FEP, ROP and high-risk syndromes for psychosis IPD were included if routine basic CSF-diagnostics were reported. Risk of bias of the included studies was evaluated. Random-effects meta-analyses and mixed-effects linear regression models were employed to assess the impact of BCB alterations on symptom severity. Published (6 studies) and unpublished IPD from n = 531 individuals was included in the analyses. CSF was altered in 38.8 % of individuals. No significant differences in symptom severity were found between individuals with and without CSF alterations (SMD = -0.17, 95 %CI -0.55-0.22, p = 0.341). However, males with elevated CSF/serum albumin ratios or any CSF alteration had significantly higher positive symptom scores than those without alterations (SMD = 0.34, 95 %CI 0.05-0.64, p = 0.037 and SMD = 0.29, 95 %CI 0.17-0.41p = 0.005, respectively). Mixed-effects and simple regression models showed no association (p > 0.1) between CSF parameters and symptomatic outcomes. No interaction between sex and CSF parameters was found (p > 0.1). BCB disruption appears highly prevalent in early psychosis and could be involved in positive symptoms severity in males, indicating potential difficult-to-treat states. This work highlights the need for considering BCB breakdownand sex-related differences in SSDs clinical trials and treatment strategies.
publishDate	2024
dc.date.none.fl_str_mv	2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://i3pt.portalinvestigacion.com/publicaciones/5448 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190358142&doi=10.1016%2fj.bbi.2024.04.011&partnerID=40&md5=90dc41ce538ec6c171edef40b8f892c9
url	https://i3pt.portalinvestigacion.com/publicaciones/5448 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190358142&doi=10.1016%2fj.bbi.2024.04.011&partnerID=40&md5=90dc41ce538ec6c171edef40b8f892c9
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ACADEMIC PRESS INC ELSEVIER SCIENCE
publisher.none.fl_str_mv	ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.source.none.fl_str_mv	BRAIN BEHAVIOR AND IMMUNITY ISSN: 08891591 ISSNe: 10902139 reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str	Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.

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