Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment

Producción Científica

Bibliographic Details
Authors: Tondo, Giacomo, Aprile, Davide, De Marchi, Fabiola, Sarasso, Barbara, Serra, Paola, Borasio, Giordana, Rojo Martínez, Esther, Arenillas Lara, Juan Francisco, Comi, Cristoforo
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Universidad de Valladolid
Repository:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/68670
Online Access:https://doi.org/10.3390/jcm12134298
https://uvadoc.uva.es/handle/10324/68670
Access Level:Open access
Keyword:Cognition disorders
Mild Cognitive Impairment
Dementia
Demencia
Nervous system - Degeneration
Sistema nervioso - Degeneración
Neurology
Neuroimmunology
Neuroinmunología
Inflammation
Inflamación
Clinical medicine
32 Ciencias Médicas
3205.07 Neurología
6104.01 Procesos Cognitivos
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oai_identifier_str oai:uvadoc.uva.es:10324/68670
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spelling Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairmentTondo, GiacomoAprile, DavideDe Marchi, FabiolaSarasso, BarbaraSerra, PaolaBorasio, GiordanaRojo Martínez, EstherArenillas Lara, Juan FranciscoComi, CristoforoCognition disordersMild Cognitive ImpairmentDementiaDemenciaNervous system - DegenerationSistema nervioso - DegeneraciónNeurologyNeurologyNeuroimmunologyNeuroinmunologíaInflammationInflamaciónClinical medicine32 Ciencias Médicas3205.07 Neurología6104.01 Procesos CognitivosProducción CientíficaGrowing evidence suggests that neuroinflammation plays a critical role in the pathogenesis of neurodegenerative diseases. Peripheral markers of inflammation, including blood cell counts and their ratios, such as the neutrophil-to-lymphocyte ratio (NLR), have been reported as an easily accessible and reliable proxy of central nervous system inflammation. However, the role of peripheral inflammation in dementia and Mild Cognitive Impairment (MCI) still needs to be clarified. In the current study, we aimed to assess the prognostic role of the NLR and other peripheral markers of inflammation in a sample of 130 amnestic MCI, followed up for two to five years. The Mini-Mental state examination (MMSE) score at baseline and follow-up visits was used to assess global cognitive status at each visit and the degree of cognitive decline over time. Baseline peripheral markers of inflammation included blood cell counts and ratios, specifically the NLR, the platelet-to-lymphocyte ratio (PLR), the monocyte-to-lymphocyte ratio (MLR), and the systemic immune inflammation index (SII). After classifying subjects into CONVERTERS and non-CONVERTERS (respectively, patients converting to dementia and subjects showing stability at the last available follow-up), we compared peripheral markers of inflammation among groups ed correlated them with cognitive measures, testing the ability of significant factors to predict conversion to dementia. In our cohort, CONVERTERS showed lower baseline MMSE scores (p-value = 0.004) than non-CONVERTERS. In addition, CONVERTERS had statistically elevated NLR (p-value = 0.005), PLR (p-value = 0.002), and SII levels (p-value = 0.015), besides a lower number of lymphocytes (p-value = 0.004) compared with non-CONVERTERS. In a logistic regression analysis, baseline MMSE scores and NLR predicted conversion to dementia. Tertiles analysis showed that MCI with the highest NLR values had a higher conversion risk. Our study supports the hypothesis that a dysregulation of peripheral inflammation involving both lymphocytes and neutrophils may play a role in the pathogenesis of dementia, even at the early stages of neurodegeneration, as in the MCI condition.El estudio fue apoyado por el Proyecto AGING del Departamento de Medicina Traslacional (DIMET) de la Universidad del Piamonte Oriental, Novara, ItaliaMDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/jcm12134298https://uvadoc.uva.es/handle/10324/68670reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/2077-0383/12/13/4298info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/686702026-06-13T12:44:47Z
dc.title.none.fl_str_mv Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
title Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
spellingShingle Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
Tondo, Giacomo
Cognition disorders
Mild Cognitive Impairment
Dementia
Demencia
Nervous system - Degeneration
Sistema nervioso - Degeneración
Neurology
Neurology
Neuroimmunology
Neuroinmunología
Inflammation
Inflamación
Clinical medicine
32 Ciencias Médicas
3205.07 Neurología
6104.01 Procesos Cognitivos
title_short Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
title_full Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
title_fullStr Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
title_full_unstemmed Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
title_sort Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
dc.creator.none.fl_str_mv Tondo, Giacomo
Aprile, Davide
De Marchi, Fabiola
Sarasso, Barbara
Serra, Paola
Borasio, Giordana
Rojo Martínez, Esther
Arenillas Lara, Juan Francisco
Comi, Cristoforo
author Tondo, Giacomo
author_facet Tondo, Giacomo
Aprile, Davide
De Marchi, Fabiola
Sarasso, Barbara
Serra, Paola
Borasio, Giordana
Rojo Martínez, Esther
Arenillas Lara, Juan Francisco
Comi, Cristoforo
author_role author
author2 Aprile, Davide
De Marchi, Fabiola
Sarasso, Barbara
Serra, Paola
Borasio, Giordana
Rojo Martínez, Esther
Arenillas Lara, Juan Francisco
Comi, Cristoforo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cognition disorders
Mild Cognitive Impairment
Dementia
Demencia
Nervous system - Degeneration
Sistema nervioso - Degeneración
Neurology
Neurology
Neuroimmunology
Neuroinmunología
Inflammation
Inflamación
Clinical medicine
32 Ciencias Médicas
3205.07 Neurología
6104.01 Procesos Cognitivos
topic Cognition disorders
Mild Cognitive Impairment
Dementia
Demencia
Nervous system - Degeneration
Sistema nervioso - Degeneración
Neurology
Neurology
Neuroimmunology
Neuroinmunología
Inflammation
Inflamación
Clinical medicine
32 Ciencias Médicas
3205.07 Neurología
6104.01 Procesos Cognitivos
description Producción Científica
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm12134298
https://uvadoc.uva.es/handle/10324/68670
url https://doi.org/10.3390/jcm12134298
https://uvadoc.uva.es/handle/10324/68670
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2077-0383/12/13/4298
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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