Co-expression gene network analysis reveals novel regulatory pathways involved in porto-sinusoidal vascular disease

[Background & Aims] Porto-sinusoidal vascular disease (PSVD) is a rare vascular liver disease of unknown etiology that causes portal hypertension. It usually affects young individuals and shortens live expectancy. The deregulated pathways involved in PSVD development are unknown and therefore we...

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Detalles Bibliográficos
Autores: Hernández-Gea, Virginia, Campreciós, Genís, Betancourt, Fabián, Pérez-Campuzano, Valeria, Seijo, Susana, Díaz, Alba, Gallego-Durán, Rocío, Olivas, Pol, Orts, Lara, Mahaz, Marta, Baiges, Anna, Turon, Fanny, Sidorova, Julia, Romero-Gómez, Manuel, Lozano, Juan José, García-Pagán, Juan Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/262938
Acceso en línea:http://hdl.handle.net/10261/262938
Access Level:acceso abierto
Palabra clave:Porto sinusoidal vascular disease
Non-cirrhotic portal hypertension
Portal hypertension
Vascular liver disease
Trasncriptomic analysis
System biology
Descripción
Sumario:[Background & Aims] Porto-sinusoidal vascular disease (PSVD) is a rare vascular liver disease of unknown etiology that causes portal hypertension. It usually affects young individuals and shortens live expectancy. The deregulated pathways involved in PSVD development are unknown and therefore we lack curative treatments. The purpose of this study was to integrate transcriptomic and clinical data by comprehensive network-based modeling in order to uncover altered biological processes in patients with PSVD.

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