The Role of Non-Coding RNAs in Autophagy During Carcinogenesis

Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway involved in self-renewal and quality control processes to maintain cellular homeostasis. The alteration of autophagy has been implicated in numerous diseases such as cancer where it plays a dual role. Autophagy se...

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Detalles Bibliográficos
Autores: Cruz-Ojeda, Patricia de la, Flores-Campos, Rocío, Navarro-Villarán, Elena, Muntané, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/306901
Acceso en línea:http://hdl.handle.net/10261/306901
https://api.elsevier.com/content/abstract/scopus_id/85126750419
Access Level:acceso abierto
Palabra clave:miRNA
Autophagy
Beclin-1
Cancer
lncRNA
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spelling The Role of Non-Coding RNAs in Autophagy During CarcinogenesisCruz-Ojeda, Patricia de laFlores-Campos, RocíoNavarro-Villarán, ElenaMuntané, JordimiRNAAutophagyBeclin-1CancerlncRNAMacroautophagy (autophagy herein) is a cellular stress response and a survival pathway involved in self-renewal and quality control processes to maintain cellular homeostasis. The alteration of autophagy has been implicated in numerous diseases such as cancer where it plays a dual role. Autophagy serves as a tumor suppressor in the early phases of cancer formation with the restoration of homeostasis and eliminating cellular altered constituents, yet in later phases, autophagy may support and/or facilitate tumor growth, metastasis and may contribute to treatment resistance. Key components of autophagy interact with either pro- and anti-apoptotic factors regulating the proximity of tumor cells to apoptotic cliff promoting cell survival. Autophagy is regulated by key cell signaling pathways such as Akt (protein kinase B, PKB), mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) involved in cell survival and metabolism. The expression of critical members of upstream cell signaling, as well as those directly involved in the autophagic and apoptotic machineries are regulated by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Consequently, non-coding RNAs play a relevant role in carcinogenesis and treatment response in cancer. The review is an update of the current knowledge in the regulation by miRNA and lncRNA of the autophagic components and their functional impact to provide an integrated and comprehensive regulatory network of autophagy in cancer.We thank the Institute of Health Carlos III (ISCiii) cofinanced by the European Regional Development Fund “A way to achieve Europe” (ERDF) (PI19/01266), the Andalusian Ministry of Health (PIP-0215-2020 and PI-0216-2020), as well as the Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) founded by the ISCiii and cofinanced by the ERDF for their financial support to J.M. E.N-V. is a recipient of a research contract from ISCiii (IFI18/00014). P.d.l.C-O. is a recipient of an FPU contract from the Spanish Ministry of Education and Vocational Training (FPU17/00026).Peer reviewedFrontiers MediaInstituto de Salud Carlos IIIEuropean CommissionJunta de AndalucíaCentro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España)Ministerio de Educación y Formación Profesional (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/306901https://api.elsevier.com/content/abstract/scopus_id/85126750419reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement///https://doi.org/10.3389/fcell.2022.799392Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3069012026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
title The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
spellingShingle The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
Cruz-Ojeda, Patricia de la
miRNA
Autophagy
Beclin-1
Cancer
lncRNA
title_short The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
title_full The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
title_fullStr The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
title_full_unstemmed The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
title_sort The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
dc.creator.none.fl_str_mv Cruz-Ojeda, Patricia de la
Flores-Campos, Rocío
Navarro-Villarán, Elena
Muntané, Jordi
author Cruz-Ojeda, Patricia de la
author_facet Cruz-Ojeda, Patricia de la
Flores-Campos, Rocío
Navarro-Villarán, Elena
Muntané, Jordi
author_role author
author2 Flores-Campos, Rocío
Navarro-Villarán, Elena
Muntané, Jordi
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Junta de Andalucía
Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España)
Ministerio de Educación y Formación Profesional (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv miRNA
Autophagy
Beclin-1
Cancer
lncRNA
topic miRNA
Autophagy
Beclin-1
Cancer
lncRNA
description Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway involved in self-renewal and quality control processes to maintain cellular homeostasis. The alteration of autophagy has been implicated in numerous diseases such as cancer where it plays a dual role. Autophagy serves as a tumor suppressor in the early phases of cancer formation with the restoration of homeostasis and eliminating cellular altered constituents, yet in later phases, autophagy may support and/or facilitate tumor growth, metastasis and may contribute to treatment resistance. Key components of autophagy interact with either pro- and anti-apoptotic factors regulating the proximity of tumor cells to apoptotic cliff promoting cell survival. Autophagy is regulated by key cell signaling pathways such as Akt (protein kinase B, PKB), mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) involved in cell survival and metabolism. The expression of critical members of upstream cell signaling, as well as those directly involved in the autophagic and apoptotic machineries are regulated by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Consequently, non-coding RNAs play a relevant role in carcinogenesis and treatment response in cancer. The review is an update of the current knowledge in the regulation by miRNA and lncRNA of the autophagic components and their functional impact to provide an integrated and comprehensive regulatory network of autophagy in cancer.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/306901
https://api.elsevier.com/content/abstract/scopus_id/85126750419
url http://hdl.handle.net/10261/306901
https://api.elsevier.com/content/abstract/scopus_id/85126750419
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement///
https://doi.org/10.3389/fcell.2022.799392
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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