Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK

Background: Chagas disease (CD), is a parasitic disease endemic in Latin America. Presentation in non-endemic areas is either in the asymptomatic indeterminate phase or the chronic phase with cardiac and/or gastrointestinal complications. Methods: The Hospital for Tropical Diseases (HTD) based in ce...

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Authors: González Sanz, Marta, Sario, Valentina De, García Mingo, Ana, Nolder, Debbie, Dawood, Naghum, Álvarez Martínez, Míriam, Daly, Rosemarie, Lowe, Patricia, Yacoub, Sophie, Moore, David A. J., Chiodini, Peter L.
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174061
Online Access:https://hdl.handle.net/2445/174061
Access Level:Open access
Keyword:Malaltia de Chagas
Gran Bretanya
Chagas' disease
Great Britain
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spelling Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UKGonzález Sanz, MartaSario, Valentina DeGarcía Mingo, AnaNolder, DebbieDawood, NaghumÁlvarez Martínez, MíriamDaly, RosemarieLowe, PatriciaYacoub, SophieMoore, David A. J.Chiodini, Peter L.Malaltia de ChagasGran BretanyaChagas' diseaseGreat BritainBackground: Chagas disease (CD), is a parasitic disease endemic in Latin America. Presentation in non-endemic areas is either in the asymptomatic indeterminate phase or the chronic phase with cardiac and/or gastrointestinal complications. Methods: The Hospital for Tropical Diseases (HTD) based in central London, provides tertiary care for the management of CD. We reviewed all cases managed at this centre between 1995 and 2018. Results: Sixty patients with serologically proven CD were identified. Most were female (70%), with a median age at diagnosis of 41 years. Three quarters of the patients were originally from Bolivia. 62% of all patients were referred to the HTD by their GP. Nearly half of the patients were asymptomatic (47%). Twelve patients had signs of cardiac involvement secondary to CD. Evidence of gastrointestinal damage was established in three patients. Treatment was provided at HTD for 31 patients (47%). Most patients (29) received benznidazole, five of them did not tolerate the course and were switched to nifurtimox. Of the seven patients receiving this second line drug, five completed treatment, whilst two interrupted it due to side effects. Conclusions: Despite the UK health system having all the resources required to diagnose, treat and follow up cases, there is lack of awareness of CD, such that the vast majority of cases remain undiagnosed and therefore do not receive treatment. We propose key interventions to improve the detection and management of this condition in the UK, especially in pregnant women and neonates.Elsevier Ltd.2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/174061Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1016/j.tmaid.2020.101760Travel Medicine and Infectious Disease, 2020, vol. 36http://dx.doi.org/10.1016/j.tmaid.2020.101760cc by-nc-nd (c) Elsevier Ltd., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1740612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
title Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
spellingShingle Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
González Sanz, Marta
Malaltia de Chagas
Gran Bretanya
Chagas' disease
Great Britain
title_short Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
title_full Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
title_fullStr Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
title_full_unstemmed Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
title_sort Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
dc.creator.none.fl_str_mv González Sanz, Marta
Sario, Valentina De
García Mingo, Ana
Nolder, Debbie
Dawood, Naghum
Álvarez Martínez, Míriam
Daly, Rosemarie
Lowe, Patricia
Yacoub, Sophie
Moore, David A. J.
Chiodini, Peter L.
author González Sanz, Marta
author_facet González Sanz, Marta
Sario, Valentina De
García Mingo, Ana
Nolder, Debbie
Dawood, Naghum
Álvarez Martínez, Míriam
Daly, Rosemarie
Lowe, Patricia
Yacoub, Sophie
Moore, David A. J.
Chiodini, Peter L.
author_role author
author2 Sario, Valentina De
García Mingo, Ana
Nolder, Debbie
Dawood, Naghum
Álvarez Martínez, Míriam
Daly, Rosemarie
Lowe, Patricia
Yacoub, Sophie
Moore, David A. J.
Chiodini, Peter L.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Chagas
Gran Bretanya
Chagas' disease
Great Britain
topic Malaltia de Chagas
Gran Bretanya
Chagas' disease
Great Britain
description Background: Chagas disease (CD), is a parasitic disease endemic in Latin America. Presentation in non-endemic areas is either in the asymptomatic indeterminate phase or the chronic phase with cardiac and/or gastrointestinal complications. Methods: The Hospital for Tropical Diseases (HTD) based in central London, provides tertiary care for the management of CD. We reviewed all cases managed at this centre between 1995 and 2018. Results: Sixty patients with serologically proven CD were identified. Most were female (70%), with a median age at diagnosis of 41 years. Three quarters of the patients were originally from Bolivia. 62% of all patients were referred to the HTD by their GP. Nearly half of the patients were asymptomatic (47%). Twelve patients had signs of cardiac involvement secondary to CD. Evidence of gastrointestinal damage was established in three patients. Treatment was provided at HTD for 31 patients (47%). Most patients (29) received benznidazole, five of them did not tolerate the course and were switched to nifurtimox. Of the seven patients receiving this second line drug, five completed treatment, whilst two interrupted it due to side effects. Conclusions: Despite the UK health system having all the resources required to diagnose, treat and follow up cases, there is lack of awareness of CD, such that the vast majority of cases remain undiagnosed and therefore do not receive treatment. We propose key interventions to improve the detection and management of this condition in the UK, especially in pregnant women and neonates.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174061
url https://hdl.handle.net/2445/174061
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1016/j.tmaid.2020.101760
Travel Medicine and Infectious Disease, 2020, vol. 36
http://dx.doi.org/10.1016/j.tmaid.2020.101760
dc.rights.none.fl_str_mv cc by-nc-nd (c) Elsevier Ltd., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Elsevier Ltd., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd.
publisher.none.fl_str_mv Elsevier Ltd.
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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