Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome

Dravet syndrome is a rare form of severe genetic epilepsy characterized by recurrent and long-lasting seizures. It appears around the first year of life, with a quick evolution toward an increase in the frequency of the seizures, accompanied by a delay in motor and cognitive development, and does no...

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Autores: Rivadulla, Casto, Pardo-Vázquez, José Luís, Labra, Carmen de, Aguilar, J., Suárez, Eduardo, Paz, Concepción, Álvarez-Dolado, Manuel, Cudeiro, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/347103
Acceso en línea:http://hdl.handle.net/10261/347103
https://api.elsevier.com/content/abstract/scopus_id/85174713898
Access Level:acceso abierto
Palabra clave:Dravet
Epilepsy
Magnetic stimulation
Non invasive neuromodulation
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spelling Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndromeRivadulla, CastoPardo-Vázquez, José LuísLabra, Carmen deAguilar, J.Suárez, EduardoPaz, ConcepciónÁlvarez-Dolado, ManuelCudeiro, JavierDravetEpilepsyMagnetic stimulationNon invasive neuromodulationDravet syndrome is a rare form of severe genetic epilepsy characterized by recurrent and long-lasting seizures. It appears around the first year of life, with a quick evolution toward an increase in the frequency of the seizures, accompanied by a delay in motor and cognitive development, and does not respond well to antiepileptic medication. Most patients carry a mutation in the gene SCN1A encoding the α subunit of the voltage-gated sodium channel Nav1.1, resulting in hyperexcitability of neural circuits and seizure onset. In this work, we applied transcranial static magnetic stimulation (tSMS), a non-invasive, safe, easy-to-use and affordable neuromodulatory tool that reduces neural excitability in a mouse model of Dravet syndrome. We demonstrate that tSMS dramatically reduced the number of crises. Furthermore, crises recorded in the presence of the tSMS were shorter and less intense than in the sham condition. Since tSMS has demonstrated its efficacy at reducing cortical excitability in humans without showing unwanted side effects, in an attempt to anticipate a possible use of tSMS for Dravet Syndrome patients, we performed a numerical simulation in which the magnetic field generated by the magnet was modeled to estimate the magnetic field intensity reached in the cerebral cortex, which could help to design stimulation strategies in these patients. Our results provide a proof of concept for nonpharmacological treatment of Dravet syndrome, which opens the door to the design of new protocols for treatment.Instituto de salud Carlos III (ISCIII) PI21/00151, co-funded by the European Union Xunta de Galicia, Grupos de referencia competitiva 2021 ED431C 2022/05 (CR) Ministerio de Ciencia e Innovacion PID2019-108250RJ-100 Xunta de Galicia, Grupos con Pontencial Crecimiento 2021 (JPV). Apoyo Dravet (MAD). JPV has a contract under the Ramon y Cajal program (RYC2019–026380-I).Peer reviewedElsevierInstituto de Salud Carlos IIIEuropean CommissionXunta de GaliciaAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Apoyo DravetConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/347103https://api.elsevier.com/content/abstract/scopus_id/85174713898reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00151info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108250RJ-I00info:eu-repo/grantAgreement/AEI//RYC2019-026380-IThe underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1016/j.expneurol.2023.114581https://doi.org/10.1016/j.expneurol.2023.114581Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3471032026-05-22T06:33:51Z
dc.title.none.fl_str_mv Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
spellingShingle Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
Rivadulla, Casto
Dravet
Epilepsy
Magnetic stimulation
Non invasive neuromodulation
title_short Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title_full Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title_fullStr Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title_full_unstemmed Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title_sort Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
dc.creator.none.fl_str_mv Rivadulla, Casto
Pardo-Vázquez, José Luís
Labra, Carmen de
Aguilar, J.
Suárez, Eduardo
Paz, Concepción
Álvarez-Dolado, Manuel
Cudeiro, Javier
author Rivadulla, Casto
author_facet Rivadulla, Casto
Pardo-Vázquez, José Luís
Labra, Carmen de
Aguilar, J.
Suárez, Eduardo
Paz, Concepción
Álvarez-Dolado, Manuel
Cudeiro, Javier
author_role author
author2 Pardo-Vázquez, José Luís
Labra, Carmen de
Aguilar, J.
Suárez, Eduardo
Paz, Concepción
Álvarez-Dolado, Manuel
Cudeiro, Javier
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Xunta de Galicia
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Apoyo Dravet
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Dravet
Epilepsy
Magnetic stimulation
Non invasive neuromodulation
topic Dravet
Epilepsy
Magnetic stimulation
Non invasive neuromodulation
description Dravet syndrome is a rare form of severe genetic epilepsy characterized by recurrent and long-lasting seizures. It appears around the first year of life, with a quick evolution toward an increase in the frequency of the seizures, accompanied by a delay in motor and cognitive development, and does not respond well to antiepileptic medication. Most patients carry a mutation in the gene SCN1A encoding the α subunit of the voltage-gated sodium channel Nav1.1, resulting in hyperexcitability of neural circuits and seizure onset. In this work, we applied transcranial static magnetic stimulation (tSMS), a non-invasive, safe, easy-to-use and affordable neuromodulatory tool that reduces neural excitability in a mouse model of Dravet syndrome. We demonstrate that tSMS dramatically reduced the number of crises. Furthermore, crises recorded in the presence of the tSMS were shorter and less intense than in the sham condition. Since tSMS has demonstrated its efficacy at reducing cortical excitability in humans without showing unwanted side effects, in an attempt to anticipate a possible use of tSMS for Dravet Syndrome patients, we performed a numerical simulation in which the magnetic field generated by the magnet was modeled to estimate the magnetic field intensity reached in the cerebral cortex, which could help to design stimulation strategies in these patients. Our results provide a proof of concept for nonpharmacological treatment of Dravet syndrome, which opens the door to the design of new protocols for treatment.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/347103
https://api.elsevier.com/content/abstract/scopus_id/85174713898
url http://hdl.handle.net/10261/347103
https://api.elsevier.com/content/abstract/scopus_id/85174713898
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00151
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108250RJ-I00
info:eu-repo/grantAgreement/AEI//RYC2019-026380-I
The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1016/j.expneurol.2023.114581
https://doi.org/10.1016/j.expneurol.2023.114581
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
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