Immunogenètica i Immunopatogènia de la infecció pel VIH-1 en la població espanyola. Influència sobre la història natural de la infecció.
Thesis based on 3 immunogenetics studies whose objective are to determine whether the major allelic variants of the main HIV-1 coreceptors through which HIV-1 enters into host cells (CCR5 and CXCR4) and their natural and respective ligands RANTES and SDF-1 chemokines, modulate the risk of infection...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | España |
| Institución: | Universitat Rovira i virgili (URV) |
| Repositorio: | Repositori Institucional de la Universitat Rovira i Virgili |
| OAI Identifier: | oai:urv.cat:TDX:636 |
| Acceso en línea: | https://hdl.handle.net/20.500.11797/TDX636 http://hdl.handle.net/10803/8858 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.9 - Malalties infeccioses i contagioses. Febres 61 - Medicina 577 - Bioquímica. Biologia molecular. Biofísica 575 - Genètica general. Citogenètica general. Immunogenètica. Evolució. Filogènia |
| Sumario: | Thesis based on 3 immunogenetics studies whose objective are to determine whether the major allelic variants of the main HIV-1 coreceptors through which HIV-1 enters into host cells (CCR5 and CXCR4) and their natural and respective ligands RANTES and SDF-1 chemokines, modulate the risk of infection and/or the natural history in a cohort of Spanish Caucasian patients. A fourth immunopathogenic study evaluates the posible relationship between mitochondrial damage and apoptosis, both HIV-1 induced, in peripheral blood mononuclear cells (PBMC). The immunogenetic studies do not find any association between chemokines allelic variants and HIV-1 coreceptors in long-term non progressor patients. In the immunopathogenic study an association between mitochondrial damage and apoptosis is found in the PBMCs of patients with active HIV-1 replication. |
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