Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy
Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics, mainly mediated by the expression of inducible chromosomic β-lactamases and the production of constitutive or inducible efflux pumps. Apart from this intrinsic resistance, P. aeruginosa possess an extraordinary...
| Autores: | , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/157177 |
| Acceso en línea: | https://hdl.handle.net/2445/157177 |
| Access Level: | acceso abierto |
| Palabra clave: | Malalties infeccioses Pseudomonas Bacteris gramnegatius Antibiòtics Communicable diseases Gram-negative bacteria Antibiotics |
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Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of ChemotherapyMensa Pueyo, JosepBarberán, JoséSoriano Viladomiu, AlexLlinares, PedroMarco Reverté, FrancescCantón, RafaelBou, GermánGonzález del Castillo, JuanMaseda, EmilioAzanza, José RamónPasquau, JuanGarcia Vidal, CarolinaReguera, José MaríaSousa, DoloresGómez, JoaquínMontejo, MiguelBorges, MarcioTorres Martí, AntoniÁlvarez Lerma, FranciscoSalavert, MiguelZaragoza, RafaelOliver, AntoniMalalties infecciosesPseudomonasBacteris gramnegatiusAntibiòticsCommunicable diseasesPseudomonasGram-negative bacteriaAntibioticsPseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics, mainly mediated by the expression of inducible chromosomic β-lactamases and the production of constitutive or inducible efflux pumps. Apart from this intrinsic resistance, P. aeruginosa possess an extraordinary ability to develop resistance to nearly all available antimicrobials through selection of mutations. The progressive increase in resistance rates in P. aeruginosa has led to the emergence of strains which, based on their degree of resistance to common antibiotics, have been defined as multidrug resistant, extended-resistant and panresistant strains. These strains are increasingly disseminated worldwide, progressively complicating the treatment of P. aeruginosa infections. In this scenario, the objective of the present guidelines was to review and update published evidence for the treatment of patients with acute, invasive and severe infections caused by P. aeruginosa. To this end, mechanisms of intrinsic resistance, factors favoring development of resistance during antibiotic exposure, prevalence of resistance in Spain, classical and recently appeared new antibiotics active against P. aeruginosa, pharmacodynamic principles predicting efficacy, clinical experience with monotherapy and combination therapy, and principles for antibiotic treatment were reviewed to elaborate recommendations by the panel of experts for empirical and directed treatment of P. aeruginosa invasive infections.Sociedad Española de Quimioterapia2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion23 p.application/pdfhttps://hdl.handle.net/2445/157177Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://seq.es/wp-content/uploads/2018/02/rev-esp-quimioter-2018-february-23-2; https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29480677/Revista Espanola de Quimioterapia, 2018, vol. 31, num. 1, p. 78-100(c) Sociedad Española de Quimioterapia, 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1571772026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy |
| title |
Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy |
| spellingShingle |
Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy Mensa Pueyo, Josep Malalties infeccioses Pseudomonas Bacteris gramnegatius Antibiòtics Communicable diseases Pseudomonas Gram-negative bacteria Antibiotics |
| title_short |
Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy |
| title_full |
Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy |
| title_fullStr |
Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy |
| title_full_unstemmed |
Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy |
| title_sort |
Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy |
| dc.creator.none.fl_str_mv |
Mensa Pueyo, Josep Barberán, José Soriano Viladomiu, Alex Llinares, Pedro Marco Reverté, Francesc Cantón, Rafael Bou, Germán González del Castillo, Juan Maseda, Emilio Azanza, José Ramón Pasquau, Juan Garcia Vidal, Carolina Reguera, José María Sousa, Dolores Gómez, Joaquín Montejo, Miguel Borges, Marcio Torres Martí, Antoni Álvarez Lerma, Francisco Salavert, Miguel Zaragoza, Rafael Oliver, Antoni |
| author |
Mensa Pueyo, Josep |
| author_facet |
Mensa Pueyo, Josep Barberán, José Soriano Viladomiu, Alex Llinares, Pedro Marco Reverté, Francesc Cantón, Rafael Bou, Germán González del Castillo, Juan Maseda, Emilio Azanza, José Ramón Pasquau, Juan Garcia Vidal, Carolina Reguera, José María Sousa, Dolores Gómez, Joaquín Montejo, Miguel Borges, Marcio Torres Martí, Antoni Álvarez Lerma, Francisco Salavert, Miguel Zaragoza, Rafael Oliver, Antoni |
| author_role |
author |
| author2 |
Barberán, José Soriano Viladomiu, Alex Llinares, Pedro Marco Reverté, Francesc Cantón, Rafael Bou, Germán González del Castillo, Juan Maseda, Emilio Azanza, José Ramón Pasquau, Juan Garcia Vidal, Carolina Reguera, José María Sousa, Dolores Gómez, Joaquín Montejo, Miguel Borges, Marcio Torres Martí, Antoni Álvarez Lerma, Francisco Salavert, Miguel Zaragoza, Rafael Oliver, Antoni |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Malalties infeccioses Pseudomonas Bacteris gramnegatius Antibiòtics Communicable diseases Pseudomonas Gram-negative bacteria Antibiotics |
| topic |
Malalties infeccioses Pseudomonas Bacteris gramnegatius Antibiòtics Communicable diseases Pseudomonas Gram-negative bacteria Antibiotics |
| description |
Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics, mainly mediated by the expression of inducible chromosomic β-lactamases and the production of constitutive or inducible efflux pumps. Apart from this intrinsic resistance, P. aeruginosa possess an extraordinary ability to develop resistance to nearly all available antimicrobials through selection of mutations. The progressive increase in resistance rates in P. aeruginosa has led to the emergence of strains which, based on their degree of resistance to common antibiotics, have been defined as multidrug resistant, extended-resistant and panresistant strains. These strains are increasingly disseminated worldwide, progressively complicating the treatment of P. aeruginosa infections. In this scenario, the objective of the present guidelines was to review and update published evidence for the treatment of patients with acute, invasive and severe infections caused by P. aeruginosa. To this end, mechanisms of intrinsic resistance, factors favoring development of resistance during antibiotic exposure, prevalence of resistance in Spain, classical and recently appeared new antibiotics active against P. aeruginosa, pharmacodynamic principles predicting efficacy, clinical experience with monotherapy and combination therapy, and principles for antibiotic treatment were reviewed to elaborate recommendations by the panel of experts for empirical and directed treatment of P. aeruginosa invasive infections. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2020 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/157177 |
| url |
https://hdl.handle.net/2445/157177 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://seq.es/wp-content/uploads/2018/02/rev-esp-quimioter-2018-february-23-2; https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29480677/ Revista Espanola de Quimioterapia, 2018, vol. 31, num. 1, p. 78-100 |
| dc.rights.none.fl_str_mv |
(c) Sociedad Española de Quimioterapia, 2018 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Sociedad Española de Quimioterapia, 2018 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
23 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Sociedad Española de Quimioterapia |
| publisher.none.fl_str_mv |
Sociedad Española de Quimioterapia |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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