Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2

Abstract: Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory multisystem syndrome (PIMS), presents significant challenges in pediatric cardiology, due to its complex molecular pathophysiology. In this retrospective analysis of 15 cases that were managed at a...

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Autores: Viadero Ubierna, María Teresa, Caldeiro Diaz, María Jesús, Fernández Suárez, Natalia, Garde Basas, Jesús, Cabero Pérez, María Jesús, González-Lamuño Leguina, Domingo
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/37497
Acceso en línea:https://hdl.handle.net/10902/37497
Access Level:acceso abierto
Palabra clave:Pediatric inflammatory multisystem syndrome (PIMS)
Multisystem inflammatory syndrome in children (MIS-C)
Myocardial dysfunction
Cytokine storm
Endothelial dysfunction
SARS-CoV-2
Kawasaki disease
Biomarkers
IVIG
Corticosteroids
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spelling Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2Viadero Ubierna, María TeresaCaldeiro Diaz, María JesúsFernández Suárez, NataliaGarde Basas, JesúsCabero Pérez, María JesúsGonzález-Lamuño Leguina, DomingoPediatric inflammatory multisystem syndrome (PIMS)Multisystem inflammatory syndrome in children (MIS-C)Myocardial dysfunctionCytokine stormEndothelial dysfunctionSARS-CoV-2Kawasaki diseaseBiomarkersIVIGCorticosteroidsAbstract: Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory multisystem syndrome (PIMS), presents significant challenges in pediatric cardiology, due to its complex molecular pathophysiology. In this retrospective analysis of 15 cases that were managed at a single tertiary care center, we investigated the molecular contributors to myocardial dysfunction, including cytokine storms, hyperinflammation markers, and hypercoagulable states. Transient myocardial involvement was identified in 46.6% of patients, with complete recovery achieved within 2?4 weeks following treatment. Ferritin, NT-ProBNP, and troponin levels were significantly elevated in patients with ventricular dysfunction compared to those without. The neutrophil-to-lymphocyte ratio (NLR), which was previously identified as a severity marker in acute COVID-19, was also significantly higher in patients with ventricular dysfunction, suggesting its potential as a prognostic indicator in MIS-C. Notably, no coronary artery aneurysms were detected in the cohort. These findings underscore the importance of early, standardized therapeutic interventions in mitigating severe outcomes, and they provide valuable insights into the molecular mechanisms driving myocardial dysfunction in MIS-C. Incorporating NLR and ferritin into the initial diagnostic workup may improve the early triage and identification of high-risk MIS-C patients.MDPIUniversidad de Cantabria20252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/37497International Journal of Molecular Sciences, 2025, 26(8), 3580reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/374972026-06-02T12:39:31Z
dc.title.none.fl_str_mv Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2
title Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2
spellingShingle Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2
Viadero Ubierna, María Teresa
Pediatric inflammatory multisystem syndrome (PIMS)
Multisystem inflammatory syndrome in children (MIS-C)
Myocardial dysfunction
Cytokine storm
Endothelial dysfunction
SARS-CoV-2
Kawasaki disease
Biomarkers
IVIG
Corticosteroids
title_short Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2
title_full Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2
title_fullStr Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2
title_full_unstemmed Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2
title_sort Molecular Mechanisms and Pathophysiology of Myocardial Disease: Insights from Pediatric Inflammatory Multisystem Syndrome (PIMS) Associated with SARS-CoV-2
dc.creator.none.fl_str_mv Viadero Ubierna, María Teresa
Caldeiro Diaz, María Jesús
Fernández Suárez, Natalia
Garde Basas, Jesús
Cabero Pérez, María Jesús
González-Lamuño Leguina, Domingo
author Viadero Ubierna, María Teresa
author_facet Viadero Ubierna, María Teresa
Caldeiro Diaz, María Jesús
Fernández Suárez, Natalia
Garde Basas, Jesús
Cabero Pérez, María Jesús
González-Lamuño Leguina, Domingo
author_role author
author2 Caldeiro Diaz, María Jesús
Fernández Suárez, Natalia
Garde Basas, Jesús
Cabero Pérez, María Jesús
González-Lamuño Leguina, Domingo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Pediatric inflammatory multisystem syndrome (PIMS)
Multisystem inflammatory syndrome in children (MIS-C)
Myocardial dysfunction
Cytokine storm
Endothelial dysfunction
SARS-CoV-2
Kawasaki disease
Biomarkers
IVIG
Corticosteroids
topic Pediatric inflammatory multisystem syndrome (PIMS)
Multisystem inflammatory syndrome in children (MIS-C)
Myocardial dysfunction
Cytokine storm
Endothelial dysfunction
SARS-CoV-2
Kawasaki disease
Biomarkers
IVIG
Corticosteroids
description Abstract: Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory multisystem syndrome (PIMS), presents significant challenges in pediatric cardiology, due to its complex molecular pathophysiology. In this retrospective analysis of 15 cases that were managed at a single tertiary care center, we investigated the molecular contributors to myocardial dysfunction, including cytokine storms, hyperinflammation markers, and hypercoagulable states. Transient myocardial involvement was identified in 46.6% of patients, with complete recovery achieved within 2?4 weeks following treatment. Ferritin, NT-ProBNP, and troponin levels were significantly elevated in patients with ventricular dysfunction compared to those without. The neutrophil-to-lymphocyte ratio (NLR), which was previously identified as a severity marker in acute COVID-19, was also significantly higher in patients with ventricular dysfunction, suggesting its potential as a prognostic indicator in MIS-C. Notably, no coronary artery aneurysms were detected in the cohort. These findings underscore the importance of early, standardized therapeutic interventions in mitigating severe outcomes, and they provide valuable insights into the molecular mechanisms driving myocardial dysfunction in MIS-C. Incorporating NLR and ferritin into the initial diagnostic workup may improve the early triage and identification of high-risk MIS-C patients.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/37497
url https://hdl.handle.net/10902/37497
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv International Journal of Molecular Sciences, 2025, 26(8), 3580
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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