The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis

Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255...

Descripción completa

Detalles Bibliográficos
Autores: Molina-Garcia, M, Fraguas, D, del Rey-Mejias, A, Mezquida, G, Sanchez-Torres, AM, Amoretti, S, Lobo, A, Gonzalez-Pinto, A, Andreu-Bernabeu, A, Corripio, I, Vieta, E, Baeza, I, Mane, A, Cuesta, M, de la Serna, E, Paya, B, Zorrilla, I, Arango, C, Bernardo, M, Rapado-Castro, M, Parellada, M, PEPs Grp
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4666
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4666
Access Level:acceso abierto
Palabra clave:psychosis
first-episode
premorbid intelligence
age at onset
functional outcome
remission
recovery
heterogeneity
subgroup
id ES_9f4ec623ab51af4debc377ea199d36bb
oai_identifier_str oai:iibsantpau.fundanetsuite.com:p4666
network_acronym_str ES
network_name_str España
repository_id_str
spelling The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of PsychosisMolina-Garcia, MFraguas, Ddel Rey-Mejias, AMezquida, GSanchez-Torres, AMAmoretti, SLobo, AGonzalez-Pinto, AAndreu-Bernabeu, ACorripio, IVieta, EBaeza, IMane, ACuesta, Mde la Serna, EPaya, BZorrilla, IArango, CBernardo, MRapado-Castro, MParellada, MPEPs Grppsychosisfirst-episodepremorbid intelligenceage at onsetfunctional outcomeremissionrecoveryheterogeneitysubgroupBackground: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ >= 85) and age of onset (early onset < 18 years; adult onset >= 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0.59), poorer functioning (d = 0.82), lower remission (61% vs. 81.1%), and clinical recovery (34.1% vs. 62.2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4666Journal of Clinical MedicineISSN: 20770383reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p46662026-06-14T12:41:47Z
dc.title.none.fl_str_mv The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
title The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
spellingShingle The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
Molina-Garcia, M
psychosis
first-episode
premorbid intelligence
age at onset
functional outcome
remission
recovery
heterogeneity
subgroup
title_short The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
title_full The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
title_fullStr The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
title_full_unstemmed The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
title_sort The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
dc.creator.none.fl_str_mv Molina-Garcia, M
Fraguas, D
del Rey-Mejias, A
Mezquida, G
Sanchez-Torres, AM
Amoretti, S
Lobo, A
Gonzalez-Pinto, A
Andreu-Bernabeu, A
Corripio, I
Vieta, E
Baeza, I
Mane, A
Cuesta, M
de la Serna, E
Paya, B
Zorrilla, I
Arango, C
Bernardo, M
Rapado-Castro, M
Parellada, M
PEPs Grp
author Molina-Garcia, M
author_facet Molina-Garcia, M
Fraguas, D
del Rey-Mejias, A
Mezquida, G
Sanchez-Torres, AM
Amoretti, S
Lobo, A
Gonzalez-Pinto, A
Andreu-Bernabeu, A
Corripio, I
Vieta, E
Baeza, I
Mane, A
Cuesta, M
de la Serna, E
Paya, B
Zorrilla, I
Arango, C
Bernardo, M
Rapado-Castro, M
Parellada, M
PEPs Grp
author_role author
author2 Fraguas, D
del Rey-Mejias, A
Mezquida, G
Sanchez-Torres, AM
Amoretti, S
Lobo, A
Gonzalez-Pinto, A
Andreu-Bernabeu, A
Corripio, I
Vieta, E
Baeza, I
Mane, A
Cuesta, M
de la Serna, E
Paya, B
Zorrilla, I
Arango, C
Bernardo, M
Rapado-Castro, M
Parellada, M
PEPs Grp
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv psychosis
first-episode
premorbid intelligence
age at onset
functional outcome
remission
recovery
heterogeneity
subgroup
topic psychosis
first-episode
premorbid intelligence
age at onset
functional outcome
remission
recovery
heterogeneity
subgroup
description Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ >= 85) and age of onset (early onset < 18 years; adult onset >= 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0.59), poorer functioning (d = 0.82), lower remission (61% vs. 81.1%), and clinical recovery (34.1% vs. 62.2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4666
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4666
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414917504761856
score 15,81155

Similares en LA Referencia