| Sumario: | Synthesis and characterization of hydrophobic DES used as the dispersed phase; NMR studies of the dispersed phase with and without the lidocaine drug loaded; NMR spectra of the DES comprising menthol and decanoic acid at a 1:2 molar ratio; NMR spectra of the pure lidocaine drug; NMR spectra with peaks of interest for 10% (w/v) lidocaine solubilized in the DES; NMR spectra with peaks of interest for 50% (w/v) lidocaine solubilized in the DES; interfacial tension measurements of the liquid phases used; experimental protocols for the membrane emulsification process, including conditions such as flow rate, pressure, and membrane properties; schematic representation of the membrane emulsification setup used in this study; comprehensive data on the characterization of the emulsions, including droplet size distribution, stability analysis, and viscosity measurements; summary of membrane emulsification experiments with relevant parameters and outcomes; characterization of the long-term storage of nanoemulsions without and with the lidocaine encapsulated; methodology and results from UPLC analysis to determine the release profile of lidocaine from the DES-in-water nanoemulsions; kinetic release studies of lidocaine drug loaded in DES-in-water nanoemulsions produced by two emulsification techniques; and kinetic models used to analyze the release kinetics of the drug, including parameters such as rate constants and fit quality for different models.
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