Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris

The original contributions presented in this study are included in the article. Additionally, raw data and metadata have been deposited with the BioProject database at the National Center for Biotechnology Information (NCBI), Available online: https://www.ncbi.nlm.nih.gov/sra/?term=PRJNA1218495 (acc...

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Autores: Bañares, Celia, Paterson, Samuel, Gómez-Garre, Dulcenombre, Ortega-Hernández, Adriana, Sánchez-González, Silvia, Cueva, Carolina, Fuente, Miguel Ángel de la, Hernández-Ledesma, Blanca, Gómez-Cortés, Pilar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/385735
Acceso en línea:http://hdl.handle.net/10261/385735
Access Level:acceso abierto
Palabra clave:Chlorella vulgaris
In vitro digestion
Colonic fermentation
Short-chain fatty acids
Gut microbiota
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spelling Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgarisBañares, CeliaPaterson, SamuelGómez-Garre, DulcenombreOrtega-Hernández, AdrianaSánchez-González, SilviaCueva, CarolinaFuente, Miguel Ángel de laHernández-Ledesma, BlancaGómez-Cortés, PilarChlorella vulgarisIn vitro digestionColonic fermentationShort-chain fatty acidsGut microbiotaThe original contributions presented in this study are included in the article. Additionally, raw data and metadata have been deposited with the BioProject database at the National Center for Biotechnology Information (NCBI), Available online: https://www.ncbi.nlm.nih.gov/sra/?term=PRJNA1218495 (accessed on 1 February 2025).This article belongs to the Special Issue Diet and Lifestyle: Impact on the Molecular and Cellular Mechanism of NCDs.Chlorella vulgaris is a source of potential bioactive compounds that can reach the large intestine and interact with colonic microbiota. However, the effects of consumption of this microalga on gastrointestinal function have scarcely been studied. This paper simulates, for the first time, the passage of C. vulgaris through the gastrointestinal tract, combining the INFOGEST method and in vitro colonic fermentation to evaluate potential effects on the human colonic microbiota composition by 16S rRNA gene sequencing and its metabolic functionality. The results show that the presence of this microalga increased the release of short-chain fatty acids (SCFAs), such as acetic, propionic, butyric, and isobutyric fatty acids, after 48 h colonic fermentation, being indicators of gut health. In correlation with the release of SCFAs, a significant reduction in bacterial groups causing intestinal imbalance, such as Enterobacteriaceae, Enterococcus spp., and Staphylococcus spp., was observed. In addition, digests from C. vulgaris favored intestinal health-related taxa, such as Akkermansia and Lactobacillus. C. vulgaris is, therefore, a promising food ingredient for good intestinal health and the maintenance of a balanced colonic microbiota.This work was supported through Project PID2021-122989OB-I00, financed by MI-CIU/AEI/10.13039/501100011033 and FEDER, EU, and Project ILINK24023 financed by the Spanish National Research Council (CSIC). C. Bañares and S. Paterson gratefully acknowledge the Spanish National Research Council (20217AT002) and the Autonomous Community of Madrid (PIPF-2022/BIO-24996) for their respective research contracts.Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas (España)Comunidad de MadridPaterson, Samuel [0000-0001-6845-7814]Gómez-Garre, Dulcenombre [0000-0002-5056-6489]Sánchez-González, Silvia [0000-0002-7331-8736]Cueva, Carolina [0000-0002-9767-919X]Hernández-Ledesma, Blanca [0000-0001-7192-6044]Gómez-Cortés, Pilar [0000-0002-2422-5744]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/385735reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#PIPF-2022/BIO-24996info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122989OB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/ijms26062754https://doi.org/10.3390/ijms26062754Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3857352026-05-22T06:33:51Z
dc.title.none.fl_str_mv Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris
title Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris
spellingShingle Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris
Bañares, Celia
Chlorella vulgaris
In vitro digestion
Colonic fermentation
Short-chain fatty acids
Gut microbiota
title_short Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris
title_full Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris
title_fullStr Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris
title_full_unstemmed Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris
title_sort Modulation of gut microbiota and short-chain fatty acid production by simulated gastrointestinal digests from microalga Chlorella vulgaris
dc.creator.none.fl_str_mv Bañares, Celia
Paterson, Samuel
Gómez-Garre, Dulcenombre
Ortega-Hernández, Adriana
Sánchez-González, Silvia
Cueva, Carolina
Fuente, Miguel Ángel de la
Hernández-Ledesma, Blanca
Gómez-Cortés, Pilar
author Bañares, Celia
author_facet Bañares, Celia
Paterson, Samuel
Gómez-Garre, Dulcenombre
Ortega-Hernández, Adriana
Sánchez-González, Silvia
Cueva, Carolina
Fuente, Miguel Ángel de la
Hernández-Ledesma, Blanca
Gómez-Cortés, Pilar
author_role author
author2 Paterson, Samuel
Gómez-Garre, Dulcenombre
Ortega-Hernández, Adriana
Sánchez-González, Silvia
Cueva, Carolina
Fuente, Miguel Ángel de la
Hernández-Ledesma, Blanca
Gómez-Cortés, Pilar
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
Comunidad de Madrid
Paterson, Samuel [0000-0001-6845-7814]
Gómez-Garre, Dulcenombre [0000-0002-5056-6489]
Sánchez-González, Silvia [0000-0002-7331-8736]
Cueva, Carolina [0000-0002-9767-919X]
Hernández-Ledesma, Blanca [0000-0001-7192-6044]
Gómez-Cortés, Pilar [0000-0002-2422-5744]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Chlorella vulgaris
In vitro digestion
Colonic fermentation
Short-chain fatty acids
Gut microbiota
topic Chlorella vulgaris
In vitro digestion
Colonic fermentation
Short-chain fatty acids
Gut microbiota
description The original contributions presented in this study are included in the article. Additionally, raw data and metadata have been deposited with the BioProject database at the National Center for Biotechnology Information (NCBI), Available online: https://www.ncbi.nlm.nih.gov/sra/?term=PRJNA1218495 (accessed on 1 February 2025).
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/385735
url http://hdl.handle.net/10261/385735
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
PIPF-2022/BIO-24996
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122989OB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/ijms26062754
https://doi.org/10.3390/ijms26062754
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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