Macular Anatomy Differs in Dyslexic Subjects

The macula, as the central part of the retina, plays an important role in the reading process. However, its morphology has not been previously studied in the context of dyslexia. In this research, we compared the thickness of the fovea, parafovea and perifovea between dyslexic subjects and normal co...

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Autores: Garcia-Medina, JJ, Bascuñana-Mas, N, Sobrado-Calvo, P, Gomez-Molina, C, Rubio-Velazquez, E, De-Paco-Matallana, M, Zanon-Moreno, V, Pinazo-Duran, MD, Del-Rio-Vellosillo, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p16944
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/16944
Access Level:acceso abierto
Palabra clave:dyslexia
reading
retina
macula
fovea
parafovea
perifovea
optical coherence tomography
thickness
segmentation
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spelling Macular Anatomy Differs in Dyslexic SubjectsGarcia-Medina, JJBascuñana-Mas, NSobrado-Calvo, PGomez-Molina, CRubio-Velazquez, EDe-Paco-Matallana, MZanon-Moreno, VPinazo-Duran, MDDel-Rio-Vellosillo, Mdyslexiareadingretinamaculafoveaparafoveaperifoveaoptical coherence tomographythicknesssegmentationThe macula, as the central part of the retina, plays an important role in the reading process. However, its morphology has not been previously studied in the context of dyslexia. In this research, we compared the thickness of the fovea, parafovea and perifovea between dyslexic subjects and normal controls, in 11 retinal segmentations obtained by optical coherence tomography (OCT). With this aim, we considered the nine sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid and also summarized data from sectors into inner ring subfield (parafovea) and outer ring subfield (perifovea). The thickness in all the four parafoveal sectors was significantly thicker in the complete retina, inner retina and middle retina of both eyes in the dyslexic group, as well as other macular sectors (fovea and perifovea) in the inner nuclear layer (INL), inner plexiform layer (IPL), IPL + INL and outer plexiform layer + outer nuclear layer (OPL + ONL). Additionally, the inner ring subfield (parafovea), but not the outer ring subfield (perifovea), was thicker in the complete retina, inner retina, middle retina (INL + OPL + ONL), OPL + ONL, IPL + INL and INL in the dyslexic group for both eyes. In contrast, no differences were found between the groups in any of the sectors or subfields of the outer retina, retinal nerve fiber layer, ganglion cell layer or ganglion cell complex in any eye. Thus, we conclude from this exploratory research that the macular morphology differs between dyslexic and normal control subjects, as measured by OCT, especially in the parafovea at middle retinal segmentations.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/16944Journal of Clinical MedicineISSN: 20770383reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p169442026-06-11T12:45:17Z
dc.title.none.fl_str_mv Macular Anatomy Differs in Dyslexic Subjects
title Macular Anatomy Differs in Dyslexic Subjects
spellingShingle Macular Anatomy Differs in Dyslexic Subjects
Garcia-Medina, JJ
dyslexia
reading
retina
macula
fovea
parafovea
perifovea
optical coherence tomography
thickness
segmentation
title_short Macular Anatomy Differs in Dyslexic Subjects
title_full Macular Anatomy Differs in Dyslexic Subjects
title_fullStr Macular Anatomy Differs in Dyslexic Subjects
title_full_unstemmed Macular Anatomy Differs in Dyslexic Subjects
title_sort Macular Anatomy Differs in Dyslexic Subjects
dc.creator.none.fl_str_mv Garcia-Medina, JJ
Bascuñana-Mas, N
Sobrado-Calvo, P
Gomez-Molina, C
Rubio-Velazquez, E
De-Paco-Matallana, M
Zanon-Moreno, V
Pinazo-Duran, MD
Del-Rio-Vellosillo, M
author Garcia-Medina, JJ
author_facet Garcia-Medina, JJ
Bascuñana-Mas, N
Sobrado-Calvo, P
Gomez-Molina, C
Rubio-Velazquez, E
De-Paco-Matallana, M
Zanon-Moreno, V
Pinazo-Duran, MD
Del-Rio-Vellosillo, M
author_role author
author2 Bascuñana-Mas, N
Sobrado-Calvo, P
Gomez-Molina, C
Rubio-Velazquez, E
De-Paco-Matallana, M
Zanon-Moreno, V
Pinazo-Duran, MD
Del-Rio-Vellosillo, M
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv dyslexia
reading
retina
macula
fovea
parafovea
perifovea
optical coherence tomography
thickness
segmentation
topic dyslexia
reading
retina
macula
fovea
parafovea
perifovea
optical coherence tomography
thickness
segmentation
description The macula, as the central part of the retina, plays an important role in the reading process. However, its morphology has not been previously studied in the context of dyslexia. In this research, we compared the thickness of the fovea, parafovea and perifovea between dyslexic subjects and normal controls, in 11 retinal segmentations obtained by optical coherence tomography (OCT). With this aim, we considered the nine sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid and also summarized data from sectors into inner ring subfield (parafovea) and outer ring subfield (perifovea). The thickness in all the four parafoveal sectors was significantly thicker in the complete retina, inner retina and middle retina of both eyes in the dyslexic group, as well as other macular sectors (fovea and perifovea) in the inner nuclear layer (INL), inner plexiform layer (IPL), IPL + INL and outer plexiform layer + outer nuclear layer (OPL + ONL). Additionally, the inner ring subfield (parafovea), but not the outer ring subfield (perifovea), was thicker in the complete retina, inner retina, middle retina (INL + OPL + ONL), OPL + ONL, IPL + INL and INL in the dyslexic group for both eyes. In contrast, no differences were found between the groups in any of the sectors or subfields of the outer retina, retinal nerve fiber layer, ganglion cell layer or ganglion cell complex in any eye. Thus, we conclude from this exploratory research that the macular morphology differs between dyslexic and normal control subjects, as measured by OCT, especially in the parafovea at middle retinal segmentations.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/16944
url https://fisabio.portalinvestigacion.com/publicaciones/16944
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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