Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model

Epigenetics is emerging as the missing link among genetic inheritance, environmental influences, and body and brain health status. In the brain, specific changes in nucleic acids or their associated proteins in neurons and glial cells might imprint differential patterns of gene activation that will...

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Autores: Griñán Ferré, Christian, Corpas Expósito, Rubén, Puigoriol Illamola, Dolors, Palomera Ávalos, Verónica, Sanfeliu i Pujol, Coral, Pallàs i Llibería, Mercè, 1964-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174290
Acceso en línea:https://hdl.handle.net/2445/174290
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Malalties neurodegeneratives
Envelliment
Epigenètica
Alzheimer's disease
Neurodegenerative Diseases
Aging
Epigenetics
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spelling Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse ModelGriñán Ferré, ChristianCorpas Expósito, RubénPuigoriol Illamola, DolorsPalomera Ávalos, VerónicaSanfeliu i Pujol, CoralPallàs i Llibería, Mercè, 1964-Malaltia d'AlzheimerMalalties neurodegenerativesEnvellimentEpigenèticaAlzheimer's diseaseNeurodegenerative DiseasesAgingEpigeneticsEpigenetics is emerging as the missing link among genetic inheritance, environmental influences, and body and brain health status. In the brain, specific changes in nucleic acids or their associated proteins in neurons and glial cells might imprint differential patterns of gene activation that will favor either cognitive enhancement or cognitive loss for more than one generation. Furthermore, derangement of age-related epigenetic signaling is appearing as a significant risk factor for illnesses of aging, including neurodegeneration and Alzheimer's disease (AD). In addition, better knowledge of epigenetic mechanisms might provide hints and clues in the triggering and progression of AD. Intense research in experimental models suggests that molecular interventions for modulating epigenetic mechanisms might have therapeutic applications to promote cognitive maintenance through an advanced age. The SAMP8 mouse is a senescence model with AD traits in which the study of epigenetic alterations may unveil epigenetic therapies against the AD. Keywords: Aging, DNA methylation, epigenetics, histone modification, neurodegenerationIOS Press2021202120182021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion21 p.application/pdfhttps://hdl.handle.net/2445/174290Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3233/JAD-170664Journal of Alzheimer's Disease, 2018, vol. 62, num. 3, p. 943-963https://doi.org/10.3233/JAD-170664(c) Griñán Ferré, Christian et al., 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1742902026-05-29T05:05:01Z
dc.title.none.fl_str_mv Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
title Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
spellingShingle Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
Griñán Ferré, Christian
Malaltia d'Alzheimer
Malalties neurodegeneratives
Envelliment
Epigenètica
Alzheimer's disease
Neurodegenerative Diseases
Aging
Epigenetics
title_short Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
title_full Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
title_fullStr Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
title_full_unstemmed Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
title_sort Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
dc.creator.none.fl_str_mv Griñán Ferré, Christian
Corpas Expósito, Rubén
Puigoriol Illamola, Dolors
Palomera Ávalos, Verónica
Sanfeliu i Pujol, Coral
Pallàs i Llibería, Mercè, 1964-
author Griñán Ferré, Christian
author_facet Griñán Ferré, Christian
Corpas Expósito, Rubén
Puigoriol Illamola, Dolors
Palomera Ávalos, Verónica
Sanfeliu i Pujol, Coral
Pallàs i Llibería, Mercè, 1964-
author_role author
author2 Corpas Expósito, Rubén
Puigoriol Illamola, Dolors
Palomera Ávalos, Verónica
Sanfeliu i Pujol, Coral
Pallàs i Llibería, Mercè, 1964-
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Malalties neurodegeneratives
Envelliment
Epigenètica
Alzheimer's disease
Neurodegenerative Diseases
Aging
Epigenetics
topic Malaltia d'Alzheimer
Malalties neurodegeneratives
Envelliment
Epigenètica
Alzheimer's disease
Neurodegenerative Diseases
Aging
Epigenetics
description Epigenetics is emerging as the missing link among genetic inheritance, environmental influences, and body and brain health status. In the brain, specific changes in nucleic acids or their associated proteins in neurons and glial cells might imprint differential patterns of gene activation that will favor either cognitive enhancement or cognitive loss for more than one generation. Furthermore, derangement of age-related epigenetic signaling is appearing as a significant risk factor for illnesses of aging, including neurodegeneration and Alzheimer's disease (AD). In addition, better knowledge of epigenetic mechanisms might provide hints and clues in the triggering and progression of AD. Intense research in experimental models suggests that molecular interventions for modulating epigenetic mechanisms might have therapeutic applications to promote cognitive maintenance through an advanced age. The SAMP8 mouse is a senescence model with AD traits in which the study of epigenetic alterations may unveil epigenetic therapies against the AD. Keywords: Aging, DNA methylation, epigenetics, histone modification, neurodegeneration
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174290
url https://hdl.handle.net/2445/174290
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3233/JAD-170664
Journal of Alzheimer's Disease, 2018, vol. 62, num. 3, p. 943-963
https://doi.org/10.3233/JAD-170664
dc.rights.none.fl_str_mv (c) Griñán Ferré, Christian et al., 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Griñán Ferré, Christian et al., 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21 p.
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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