Cognitive stimulation has potential for brain activation in individuals with Rett syndrome
Background: Knowledge regarding neuropsychological training in Rett syndrome (RS) is scarce. The aim of this study was to assess the outcome and the duration of the effect of cognitive stimulation on topographic EEG data in RS. Method: Twenty female children diagnosed with RS were included in the an...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/362342 |
| Acceso en línea: | https://hdl.handle.net/2117/362342 https://dx.doi.org/10.1111/jir.12902 |
| Access Level: | acceso abierto |
| Palabra clave: | Rett syndrome Electroencephalography Cognitive stimulation Electroencephalography (EEG) Brain symmetry index Eye tracking Rett, Síndrome de Electroencefalografia Àrees temàtiques de la UPC::Ciències de la salut |
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Cognitive stimulation has potential for brain activation in individuals with Rett syndromeMigliorelli Falcone, Carolina Mercedes|||0000-0003-2781-8841Medina Rivera, InésBachiller Matarranz, Alejandro|||0000-0001-6507-1027Tost Abadías, AnaAlonso López, Joan Francesc|||0000-0002-2980-6716López Sala, AnnaArmstrong, JuditO'Callaghan Gordo, Ma del MarPineda Marfà, MercèMañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083Romero Lafuente, Sergio|||0000-0002-8627-543XGarcía Cazorla, ÀngelsRett syndromeElectroencephalographyRett syndromeCognitive stimulationElectroencephalography (EEG)Brain symmetry indexEye trackingRett, Síndrome deElectroencefalografiaÀrees temàtiques de la UPC::Ciències de la salutBackground: Knowledge regarding neuropsychological training in Rett syndrome (RS) is scarce. The aim of this study was to assess the outcome and the duration of the effect of cognitive stimulation on topographic EEG data in RS. Method: Twenty female children diagnosed with RS were included in the analysis. Girls with RS conducted a cognitive task using an eye-tracker designed to evaluate access and choice skills. EEG data was acquired during the experimental procedure including two 10-minutes baseline stages before and after the task. Topographical changes of several EEG spectral markers including absolute and relative powers, brain symmetry index and entropy were assessed. Results: Topographic significance probability maps suggested statistical decreases on delta activity and increases on beta rhythm associated with the cognitive task. Entropy increased during and after the task, likely related to more complex brain activity. A significant positive interaction was obtained between brain symmetry index (BSI) and age showing that the improvement of interhemispheric symmetry was higher in younger girls (5-10 years). Conclusions: According to our findings, significant alterations of brain rhythms were observed during and after cognitive stimulation, suggesting that cognitive stimulation may have effects on brain activity beyond the stimulation period. Finally, our promising results also showed an increased brain symmetry that was especially relevant for the younger group. This could suggest an interaction of the eye-tracking cognitive task, however, further studies in this field are needed to assess the relation between brain asymmetries and age.We would like to acknowledge specific funding support from the Spanish Patient Associations Mi Princesa Rett and Rettando al Síndrome de Rett. This project has also received funding from Torrons Vicens and the Ministry of Science and Innovation (MICINN), Spain, under contract PID2020-117751RB-I00. CIBER-BBN is an initiative of the Instituto de Salud Carlos III, Spain. A. Bachiller is a Serra Húnter Fellow. A.García-Cazorla is supported by FIS P118/00111 “Instituto de Salud Carlos III (ISCIII)” and “Fondo Europeo de desarrollo regional (FEDER)”. A. Tost has received the predoctoral scholarship FI-AGAUR from the Generalitat de Catalunya.Peer ReviewedJohn Wiley & sons20212021-11-1820222022-02-14journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/362342https://dx.doi.org/10.1111/jir.12902reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengAgencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-117751RB-I00 TECNOLOGIAS INNOVADORAS PARA MONITORIZAR Y PERSONALIZAR LA REHABILITACION INTERDISCIPLINAR DE PACIENTES DE CUIDADO INTENSIVOopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3623422026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
Cognitive stimulation has potential for brain activation in individuals with Rett syndrome |
| title |
Cognitive stimulation has potential for brain activation in individuals with Rett syndrome |
| spellingShingle |
Cognitive stimulation has potential for brain activation in individuals with Rett syndrome Migliorelli Falcone, Carolina Mercedes|||0000-0003-2781-8841 Rett syndrome Electroencephalography Rett syndrome Cognitive stimulation Electroencephalography (EEG) Brain symmetry index Eye tracking Rett, Síndrome de Electroencefalografia Àrees temàtiques de la UPC::Ciències de la salut |
| title_short |
Cognitive stimulation has potential for brain activation in individuals with Rett syndrome |
| title_full |
Cognitive stimulation has potential for brain activation in individuals with Rett syndrome |
| title_fullStr |
Cognitive stimulation has potential for brain activation in individuals with Rett syndrome |
| title_full_unstemmed |
Cognitive stimulation has potential for brain activation in individuals with Rett syndrome |
| title_sort |
Cognitive stimulation has potential for brain activation in individuals with Rett syndrome |
| dc.creator.none.fl_str_mv |
Migliorelli Falcone, Carolina Mercedes|||0000-0003-2781-8841 Medina Rivera, Inés Bachiller Matarranz, Alejandro|||0000-0001-6507-1027 Tost Abadías, Ana Alonso López, Joan Francesc|||0000-0002-2980-6716 López Sala, Anna Armstrong, Judit O'Callaghan Gordo, Ma del Mar Pineda Marfà, Mercè Mañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083 Romero Lafuente, Sergio|||0000-0002-8627-543X García Cazorla, Àngels |
| author |
Migliorelli Falcone, Carolina Mercedes|||0000-0003-2781-8841 |
| author_facet |
Migliorelli Falcone, Carolina Mercedes|||0000-0003-2781-8841 Medina Rivera, Inés Bachiller Matarranz, Alejandro|||0000-0001-6507-1027 Tost Abadías, Ana Alonso López, Joan Francesc|||0000-0002-2980-6716 López Sala, Anna Armstrong, Judit O'Callaghan Gordo, Ma del Mar Pineda Marfà, Mercè Mañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083 Romero Lafuente, Sergio|||0000-0002-8627-543X García Cazorla, Àngels |
| author_role |
author |
| author2 |
Medina Rivera, Inés Bachiller Matarranz, Alejandro|||0000-0001-6507-1027 Tost Abadías, Ana Alonso López, Joan Francesc|||0000-0002-2980-6716 López Sala, Anna Armstrong, Judit O'Callaghan Gordo, Ma del Mar Pineda Marfà, Mercè Mañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083 Romero Lafuente, Sergio|||0000-0002-8627-543X García Cazorla, Àngels |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Rett syndrome Electroencephalography Rett syndrome Cognitive stimulation Electroencephalography (EEG) Brain symmetry index Eye tracking Rett, Síndrome de Electroencefalografia Àrees temàtiques de la UPC::Ciències de la salut |
| topic |
Rett syndrome Electroencephalography Rett syndrome Cognitive stimulation Electroencephalography (EEG) Brain symmetry index Eye tracking Rett, Síndrome de Electroencefalografia Àrees temàtiques de la UPC::Ciències de la salut |
| description |
Background: Knowledge regarding neuropsychological training in Rett syndrome (RS) is scarce. The aim of this study was to assess the outcome and the duration of the effect of cognitive stimulation on topographic EEG data in RS. Method: Twenty female children diagnosed with RS were included in the analysis. Girls with RS conducted a cognitive task using an eye-tracker designed to evaluate access and choice skills. EEG data was acquired during the experimental procedure including two 10-minutes baseline stages before and after the task. Topographical changes of several EEG spectral markers including absolute and relative powers, brain symmetry index and entropy were assessed. Results: Topographic significance probability maps suggested statistical decreases on delta activity and increases on beta rhythm associated with the cognitive task. Entropy increased during and after the task, likely related to more complex brain activity. A significant positive interaction was obtained between brain symmetry index (BSI) and age showing that the improvement of interhemispheric symmetry was higher in younger girls (5-10 years). Conclusions: According to our findings, significant alterations of brain rhythms were observed during and after cognitive stimulation, suggesting that cognitive stimulation may have effects on brain activity beyond the stimulation period. Finally, our promising results also showed an increased brain symmetry that was especially relevant for the younger group. This could suggest an interaction of the eye-tracking cognitive task, however, further studies in this field are needed to assess the relation between brain asymmetries and age. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-11-18 2022 2022-02-14 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/362342 https://dx.doi.org/10.1111/jir.12902 |
| url |
https://hdl.handle.net/2117/362342 https://dx.doi.org/10.1111/jir.12902 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Agencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-117751RB-I00 TECNOLOGIAS INNOVADORAS PARA MONITORIZAR Y PERSONALIZAR LA REHABILITACION INTERDISCIPLINAR DE PACIENTES DE CUIDADO INTENSIVO |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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John Wiley & sons |
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John Wiley & sons |
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reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
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