Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**

Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 rec...

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Detalles Bibliográficos
Autores: Morales, Paula, Navarro Brugal, Gemma, Gómez-Autet, Marc, Redondo, Laura, Fernández-Ruiz, Javier, Pérez-Benito, Laura, Cordomí, Arnau, Pardo, Leonardo, Franco Fernández, Rafael, Jagerovic, Nadine
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/179068
Acceso en línea:https://hdl.handle.net/2445/179068
Access Level:acceso abierto
Palabra clave:Receptors cel·lulars
Proteïnes G
Interacció cel·lular
Cànnabis
Cell receptors
G Proteins
Cell interaction
Cannabis
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spelling Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**Morales, PaulaNavarro Brugal, GemmaGómez-Autet, MarcRedondo, LauraFernández-Ruiz, JavierPérez-Benito, LauraCordomí, ArnauPardo, LeonardoFranco Fernández, RafaelJagerovic, NadineReceptors cel·lularsProteïnes GInteracció cel·lularCànnabisCell receptorsG ProteinsCell interactionCannabisSingle chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis.Wiley-VCH2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/179068Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1002/chem.202003389Chemistry-A European Journal, 2020, vol. 26, num. 68, p. 15839-15842https://doi.org/10.1002/chem.202003389(c) Wiley-VCH, 2020info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1790682026-05-27T06:46:51Z
dc.title.none.fl_str_mv Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
title Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
spellingShingle Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
Morales, Paula
Receptors cel·lulars
Proteïnes G
Interacció cel·lular
Cànnabis
Cell receptors
G Proteins
Cell interaction
Cannabis
title_short Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
title_full Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
title_fullStr Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
title_full_unstemmed Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
title_sort Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
dc.creator.none.fl_str_mv Morales, Paula
Navarro Brugal, Gemma
Gómez-Autet, Marc
Redondo, Laura
Fernández-Ruiz, Javier
Pérez-Benito, Laura
Cordomí, Arnau
Pardo, Leonardo
Franco Fernández, Rafael
Jagerovic, Nadine
author Morales, Paula
author_facet Morales, Paula
Navarro Brugal, Gemma
Gómez-Autet, Marc
Redondo, Laura
Fernández-Ruiz, Javier
Pérez-Benito, Laura
Cordomí, Arnau
Pardo, Leonardo
Franco Fernández, Rafael
Jagerovic, Nadine
author_role author
author2 Navarro Brugal, Gemma
Gómez-Autet, Marc
Redondo, Laura
Fernández-Ruiz, Javier
Pérez-Benito, Laura
Cordomí, Arnau
Pardo, Leonardo
Franco Fernández, Rafael
Jagerovic, Nadine
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Receptors cel·lulars
Proteïnes G
Interacció cel·lular
Cànnabis
Cell receptors
G Proteins
Cell interaction
Cannabis
topic Receptors cel·lulars
Proteïnes G
Interacció cel·lular
Cànnabis
Cell receptors
G Proteins
Cell interaction
Cannabis
description Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179068
url https://hdl.handle.net/2445/179068
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/chem.202003389
Chemistry-A European Journal, 2020, vol. 26, num. 68, p. 15839-15842
https://doi.org/10.1002/chem.202003389
dc.rights.none.fl_str_mv (c) Wiley-VCH, 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley-VCH, 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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