New insights into FAK structure and function in focal adhesions

10 p.-4 fig.

Detalles Bibliográficos
Autores: Le Coq, Johanne, Acebrón, Iván, Rodrigo Martín, Bárbara, López-Navajas, Pilar, Lietha, Daniel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/281198
Acceso en línea:http://hdl.handle.net/10261/281198
Access Level:acceso abierto
Palabra clave:Cell adhesion
Focal adhesion kinase
FAK
Structure
Function
id ES_9edf52fa9db975416ebb7eccd0fb42de
oai_identifier_str oai:digital.csic.es:10261/281198
network_acronym_str ES
network_name_str España
repository_id_str
spelling New insights into FAK structure and function in focal adhesionsLe Coq, JohanneAcebrón, IvánRodrigo Martín, BárbaraLópez-Navajas, PilarLietha, DanielCell adhesionFocal adhesion kinaseFAKStructureFunction10 p.-4 fig.Focal adhesion kinase (FAK; also known as PTK2) was discovered three decades ago and is now recognised as a key player in the regulation of cell–matrix adhesion and mesenchymal cell migration. Although it is essential during development, FAK also drives invasive cancer progression and metastasis. On a structural level, the basic building blocks of FAK have been described for some time. However, a picture of how FAK integrates into larger assemblies in various cellular environments, including one of its main cellular locations, the focal adhesion (FA) complex, is only beginning to emerge. Nano-resolution data from cellular studies, as well as atomic structures from reconstituted systems, have provided first insights, but also point to challenges that remain for obtaining a full structural understanding of how FAK is integrated in the FA complex and the structural changes occurring at different stages of FA maturation. In this Review, we discuss the known structural features of FAK, the interactions with its partners within the FA environment on the cell membrane and propose how its initial assembly in nascent FAs might change during FA maturation under force.D.L. is funded by the Ministerio de Ciencia, Innovación y Universidades for the Spanish State Research Agency Retos (grant RTI2018-099318-B-I00), and from the Ministerio de Ciencia e Innovación for the Generation of Knowledge (grant PID2021-127058NB-I00), both co-funded by the European Regional Development Fund (FEDER).Peer reviewedCompany of BiologistsMinisterio de Ciencia, Innovación y Universidades (España)Ministerio de Ciencia e Innovación (España)European CommissionLe Coq, Johanne [0000-0002-5309-3795]Acebrón, Iván [0000-0003-0397-1550]Lietha, Daniel [0000-0002-6133-6486]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/281198reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099318-B-I00https://doi.org/10.1242/jcs.259089Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2811982026-05-22T06:33:51Z
dc.title.none.fl_str_mv New insights into FAK structure and function in focal adhesions
title New insights into FAK structure and function in focal adhesions
spellingShingle New insights into FAK structure and function in focal adhesions
Le Coq, Johanne
Cell adhesion
Focal adhesion kinase
FAK
Structure
Function
title_short New insights into FAK structure and function in focal adhesions
title_full New insights into FAK structure and function in focal adhesions
title_fullStr New insights into FAK structure and function in focal adhesions
title_full_unstemmed New insights into FAK structure and function in focal adhesions
title_sort New insights into FAK structure and function in focal adhesions
dc.creator.none.fl_str_mv Le Coq, Johanne
Acebrón, Iván
Rodrigo Martín, Bárbara
López-Navajas, Pilar
Lietha, Daniel
author Le Coq, Johanne
author_facet Le Coq, Johanne
Acebrón, Iván
Rodrigo Martín, Bárbara
López-Navajas, Pilar
Lietha, Daniel
author_role author
author2 Acebrón, Iván
Rodrigo Martín, Bárbara
López-Navajas, Pilar
Lietha, Daniel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Ministerio de Ciencia e Innovación (España)
European Commission
Le Coq, Johanne [0000-0002-5309-3795]
Acebrón, Iván [0000-0003-0397-1550]
Lietha, Daniel [0000-0002-6133-6486]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cell adhesion
Focal adhesion kinase
FAK
Structure
Function
topic Cell adhesion
Focal adhesion kinase
FAK
Structure
Function
description 10 p.-4 fig.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/281198
url http://hdl.handle.net/10261/281198
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099318-B-I00
https://doi.org/10.1242/jcs.259089
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414862989295617
score 15,811543

Similares en LA Referencia