Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder

Schizophrenia is often associated with substance use disorders, particularly cannabis use disorder (CUD). However, treatments frequently fail to address both conditions simultaneously. This study aimed to evaluate the antipsychotic effectiveness of cariprazine in patients with both schizophrenia and...

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Detalles Bibliográficos
Autores: Szerman, Nestor, Vega, Pablo, Roncero, Carlos, Peris, Lola, Grau-López, Lara, Basurte-Villamor, Ignacio
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Málaga
Repositorio:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Idioma:inglés
OAI Identifier:oai:ddfv.ufv.es:10641/6861
Acceso en línea:https://hdl.handle.net/10641/6861
Access Level:acceso abierto
Palabra clave:addiction
cannabis use disorder
cariprazine
dual disorder
schizophrenia
Psychiatry and Mental health
Pharmacology (medical)
SDG 3 - Good Health and Well-being
Journal Article
Observational Study
yes
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spelling Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorderSzerman, NestorVega, PabloRoncero, CarlosPeris, LolaGrau-López, LaraBasurte-Villamor, Ignacioaddictioncannabis use disordercariprazinedual disorderschizophreniaPsychiatry and Mental healthPharmacology (medical)SDG 3 - Good Health and Well-beingJournal ArticleObservational StudyyesSchizophrenia is often associated with substance use disorders, particularly cannabis use disorder (CUD). However, treatments frequently fail to address both conditions simultaneously. This study aimed to evaluate the antipsychotic effectiveness of cariprazine in patients with both schizophrenia and CUD in a real-world setting. A 6-month observational study was conducted on 58 patients diagnosed with schizophrenia and CUD, treated with cariprazine. Antipsychotic effectiveness was measured using the Positive and Negative Syndrome Scale and the Clinical Global Impression-Schizophrenia Scale, along with the Improvement and Severity scales. Cannabis consumption and addiction severity were assessed using the Cannabis Abuse Screening Test and the Severity of Dependence Scale, while functioning was evaluated with the Sheehan Disability Inventory. Cariprazine treatment resulted in significant improvements in schizophrenia symptoms (Positive and Negative Syndrome Scale change: -47.88 points, P<0.0001; Clinical Global Impression-Schizophrenia Scale change: -8.26 points, P<0.0001). Cannabis use and dependence also decreased (Cannabis Abuse Screening Test change: -7.0 points, P<0.0001; Severity of Dependence Scale change: -7.88 points, P<0.0001), alongside improvements in functioning (Sheehan Disability Inventory change: -9.48 points, P<0.0001). These results suggest that cariprazine is effective for both schizophrenia and CUD, though further research is needed to confirm these findings.Facultad de Medicina20252025-05-0120252025-05-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10641/6861reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoriainstname:Universidad de MálagaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddfv.ufv.es:10641/68612026-06-11T12:44:57Z
dc.title.none.fl_str_mv Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder
title Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder
spellingShingle Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder
Szerman, Nestor
addiction
cannabis use disorder
cariprazine
dual disorder
schizophrenia
Psychiatry and Mental health
Pharmacology (medical)
SDG 3 - Good Health and Well-being
Journal Article
Observational Study
yes
title_short Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder
title_full Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder
title_fullStr Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder
title_full_unstemmed Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder
title_sort Cariprazine as a maintenance treatment in dual schizophrenia : A 6-month observational study in patients with schizophrenia and cannabis use disorder
dc.creator.none.fl_str_mv Szerman, Nestor
Vega, Pablo
Roncero, Carlos
Peris, Lola
Grau-López, Lara
Basurte-Villamor, Ignacio
author Szerman, Nestor
author_facet Szerman, Nestor
Vega, Pablo
Roncero, Carlos
Peris, Lola
Grau-López, Lara
Basurte-Villamor, Ignacio
author_role author
author2 Vega, Pablo
Roncero, Carlos
Peris, Lola
Grau-López, Lara
Basurte-Villamor, Ignacio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Facultad de Medicina
dc.subject.none.fl_str_mv addiction
cannabis use disorder
cariprazine
dual disorder
schizophrenia
Psychiatry and Mental health
Pharmacology (medical)
SDG 3 - Good Health and Well-being
Journal Article
Observational Study
yes
topic addiction
cannabis use disorder
cariprazine
dual disorder
schizophrenia
Psychiatry and Mental health
Pharmacology (medical)
SDG 3 - Good Health and Well-being
Journal Article
Observational Study
yes
description Schizophrenia is often associated with substance use disorders, particularly cannabis use disorder (CUD). However, treatments frequently fail to address both conditions simultaneously. This study aimed to evaluate the antipsychotic effectiveness of cariprazine in patients with both schizophrenia and CUD in a real-world setting. A 6-month observational study was conducted on 58 patients diagnosed with schizophrenia and CUD, treated with cariprazine. Antipsychotic effectiveness was measured using the Positive and Negative Syndrome Scale and the Clinical Global Impression-Schizophrenia Scale, along with the Improvement and Severity scales. Cannabis consumption and addiction severity were assessed using the Cannabis Abuse Screening Test and the Severity of Dependence Scale, while functioning was evaluated with the Sheehan Disability Inventory. Cariprazine treatment resulted in significant improvements in schizophrenia symptoms (Positive and Negative Syndrome Scale change: -47.88 points, P<0.0001; Clinical Global Impression-Schizophrenia Scale change: -8.26 points, P<0.0001). Cannabis use and dependence also decreased (Cannabis Abuse Screening Test change: -7.0 points, P<0.0001; Severity of Dependence Scale change: -7.88 points, P<0.0001), alongside improvements in functioning (Sheehan Disability Inventory change: -9.48 points, P<0.0001). These results suggest that cariprazine is effective for both schizophrenia and CUD, though further research is needed to confirm these findings.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-05-01
2025
2025-05-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10641/6861
url https://hdl.handle.net/10641/6861
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname:Universidad de Málaga
instname_str Universidad de Málaga
reponame_str DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
collection DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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