The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery

Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-u...

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Authors: Martínez-Moreno, Jose M., Mela, Virginia, Agüera, Zaida, Alvarez-Bermudez, Maria D., Martín-Reyes, Flores, Granero, Roser, Sánchez-García, Ana, Oliva-Olivera, Wilfredo, Tomé, Monica, Moreno-Ruiz, Francisco J., Soler-Humanes, Rocío, Fernández-Serrano, Jose L., Sánchez-Gallegos, Pilar, Sancho-Marín, Raquel, Fernández Aranda, Fernando, García-Fuentes, Eduardo, Tinahones, Francisco J., Garrido-Sánchez, Lourdes
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/209237
Online Access:https://hdl.handle.net/2445/209237
Access Level:Open access
Keyword:Obesitat
Cirurgia de l'obesitat
Depressió psíquica
Obesity
Obesity surgery
Mental depression
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spelling The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgeryMartínez-Moreno, Jose M.Mela, VirginiaAgüera, ZaidaAlvarez-Bermudez, Maria D.Martín-Reyes, FloresGranero, RoserSánchez-García, AnaOliva-Olivera, WilfredoTomé, MonicaMoreno-Ruiz, Francisco J.Soler-Humanes, RocíoFernández-Serrano, Jose L.Sánchez-Gallegos, PilarSancho-Marín, RaquelFernández Aranda, FernandoGarcía-Fuentes, EduardoTinahones, Francisco J.Garrido-Sánchez, LourdesObesitatCirurgia de l'obesitatDepressió psíquicaObesityObesity surgeryMental depressionBackground: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into "good responders" and "non-responders" depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning-physical, role functioning-emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.MDPI2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion17 p.application/pdfhttps://hdl.handle.net/2445/209237Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nu15194109Nutrients, 2023, vol. 15, num.19https://doi.org/10.3390/nu15194109cc-by (c) Mela, V. et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2092372026-05-29T05:05:01Z
dc.title.none.fl_str_mv The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
spellingShingle The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
Martínez-Moreno, Jose M.
Obesitat
Cirurgia de l'obesitat
Depressió psíquica
Obesity
Obesity surgery
Mental depression
title_short The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title_full The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title_fullStr The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title_full_unstemmed The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title_sort The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
dc.creator.none.fl_str_mv Martínez-Moreno, Jose M.
Mela, Virginia
Agüera, Zaida
Alvarez-Bermudez, Maria D.
Martín-Reyes, Flores
Granero, Roser
Sánchez-García, Ana
Oliva-Olivera, Wilfredo
Tomé, Monica
Moreno-Ruiz, Francisco J.
Soler-Humanes, Rocío
Fernández-Serrano, Jose L.
Sánchez-Gallegos, Pilar
Sancho-Marín, Raquel
Fernández Aranda, Fernando
García-Fuentes, Eduardo
Tinahones, Francisco J.
Garrido-Sánchez, Lourdes
author Martínez-Moreno, Jose M.
author_facet Martínez-Moreno, Jose M.
Mela, Virginia
Agüera, Zaida
Alvarez-Bermudez, Maria D.
Martín-Reyes, Flores
Granero, Roser
Sánchez-García, Ana
Oliva-Olivera, Wilfredo
Tomé, Monica
Moreno-Ruiz, Francisco J.
Soler-Humanes, Rocío
Fernández-Serrano, Jose L.
Sánchez-Gallegos, Pilar
Sancho-Marín, Raquel
Fernández Aranda, Fernando
García-Fuentes, Eduardo
Tinahones, Francisco J.
Garrido-Sánchez, Lourdes
author_role author
author2 Mela, Virginia
Agüera, Zaida
Alvarez-Bermudez, Maria D.
Martín-Reyes, Flores
Granero, Roser
Sánchez-García, Ana
Oliva-Olivera, Wilfredo
Tomé, Monica
Moreno-Ruiz, Francisco J.
Soler-Humanes, Rocío
Fernández-Serrano, Jose L.
Sánchez-Gallegos, Pilar
Sancho-Marín, Raquel
Fernández Aranda, Fernando
García-Fuentes, Eduardo
Tinahones, Francisco J.
Garrido-Sánchez, Lourdes
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Cirurgia de l'obesitat
Depressió psíquica
Obesity
Obesity surgery
Mental depression
topic Obesitat
Cirurgia de l'obesitat
Depressió psíquica
Obesity
Obesity surgery
Mental depression
description Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into "good responders" and "non-responders" depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning-physical, role functioning-emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/209237
url https://hdl.handle.net/2445/209237
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu15194109
Nutrients, 2023, vol. 15, num.19
https://doi.org/10.3390/nu15194109
dc.rights.none.fl_str_mv cc-by (c) Mela, V. et al., 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Mela, V. et al., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414850190376960
score 15,812429

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